Ọrịa Hyperimmunoglobulin E

Ọrịa Hyperimmunoglobulin E bụ ọrịa a na-adịghị ahụkebe, eketa. Ọ na - ebute nsogbu na anụahụ, mmehie, ngụgụ, ọkpụkpụ, na ezé.

A na-akpọkwa ọrịa Hyperimmunoglobulin E Job syndrome. A na - akpọ ya aha nke Akwụkwọ Nsọ Job, bụ onye nwalere ikwesị ntụkwasị obi ya site na nhụjuanya na ọnya anụ na pustules. Ndị mmadụ nwere ụdị ọrịa a na-arịa ọrịa ogbu oge.

Ihe mgbaàmà ahụ na-adịkarị na nwata, mana n'ihi na ọrịa ahụ adịkarịghị ụkọ, ọ na-ewe ọtụtụ afọ tupu emee nchoputa ziri ezi.

Nnyocha e mere na nso nso a na-egosi na ọrịa a na-ebutekarị mgbanwe mgbanwe mkpụrụ ndụ (mgbanwe) nke na-eme na STAT3gene on chromosome 17. Otu esi eme ka ndi mmadu ghara inwe oria a amaghi nke oma. Agbanyeghị, ndị nwere ọrịa a nwere ogo karịrị nke nkịtị nke mgbochi a na-akpọ IgE.

Mgbaàmà gụnyere:

• Ọkpụkpụ na ezé ezé, gụnyere mgbaji ọkpụkpụ na idapụ nwa eze n'oge
• Cba
• Akpụkpọ anụ ahụ na ọrịa
• Ugboro ugboro mmehie
• Ugboro ugboro na-efe efe

Nyocha nke anụ ahụ nwere ike igosi:

• Ọkpụkpụ azụ (kyphoscoliosis)
• Osteomyelitis
• Tinyegharịa mmehie mmehie

Nnwale ndị e mere iji gosi nchoputa ahụ gụnyere:

• Eosinophil zuru oke
• CBC na ọbara dị iche
• Ọbara globulin electrophoresis ịchọ ọbara dị elu IgE
• Mkpụrụ ndụ ihe nketa ule nke STAT3 mkpụrụ ndụ ihe nketa

Nlere anya nwere ike ikpughe ihe ịrịba ama nke ọrịa anya akọrọ.

Igwe x-ray nwere ike ikpughe nsị ume.

Nyocha ndị ọzọ enwere ike ịme:

• Nyocha CT nke igbe
• Omenala nke saịtị oria
• Nyocha ọbara pụrụ iche iji chọpụta akụkụ nke usoro ahụ ji alụso ọrịa ọgụ
• X-ray nke ọkpụkpụ
• CT i ofomi nke sinuses

Akara usoro nke jikọtara nsogbu dị iche iche nke ọrịa Hyper IgE nwere ike iji nyere aka mee nchoputa.

O nweghi ọgwụgwọ a ma ama maka ọnọdụ a. Ebumnuche nke ọgwụgwọ bụ ịchịkwa ọrịa ndị ahụ. Ọgwụ gụnyere:

• Ọgwụ nje
• Antifungal na antiviral ọgwụ (mgbe o kwesịrị ekwesị)

Gerywa ahụ na-mgbe ụfọdụ mkpa igbapu etuto.

Gamma globulin enyere site na akwara (IV) nwere ike inye aka wulite sistemu nchekwa ma ọ bụrụ na ị nwere ọrịa dị egwu.

Ọrịa Hyper IgE bụ ọnọdụ na-adịghị ala ala. Ọrịa ọhụrụ ọ bụla chọrọ ọgwụgwọ.

Nsogbu nwere ike ịgụnye:

• Ugboro ugboro na-efe efe
• Nkem

Kpọọ onye nlekọta ahụike gị ma ọ bụrụ na ị nwere mgbaàmà nke ọrịa Hyper IgE.

Onweghi uzo putara ihe iji gbochie oria Hyper IgE. Hygidị ọcha n’ozuzu ya na-enye aka igbochi ọrịa anụ ahụ.

Providersfọdụ ndị na-enye ọrụ nwere ike ịkwado ọgwụ mgbochi mgbochi maka ndị na-ebute ọtụtụ ọrịa, ọkachasị Staphylococcus aureus. Usoro ọgwụgwọ a agbanweghị ọnọdụ ahụ, mana ọ nwere ike belata nsogbu ya.

Ọrịa Job; Ọrịa Hyper IgE

Chong H, Green T, Larkin A. Allergy na immunology. Na: Zitelli BJ, McIntire SC, Nowalk AJ, eds. Zitelli na Davis 'Atlas nke nyocha umuaka umuaka. Nke 7. Philadelphia, PA: Elsevier; 2018: isi 4.

Holland SM, Gallin JI. Nyocha nke onye ọrịa ahụ chere na enweghị ikike. Na: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, na Bennett Prinkpụrụ na Omume nke Ọrịa Na-efe Ọrịa. Agba nke 9. Philadelphia, PA: Elsevier; 2020: isi 12.

Hsu AP, Davis J, Puck JM, Holland SM, Freeman AF. Autosomal nke kachasị hyper IgE syndrome. Gene Nyocha. Ọrịa. 2012; 6. PMID: 20301786 www.ncbi.nlm.nih.gov/pubmed/20301786. Emelitere June 7, 2012. Nabata July 30, 2019.