Membranoproliferative glomerulonephritis

Membranoproliferative glomerulonephritis bụ nsogbu akụrụ na-emetụta nsị na mgbanwe na mkpụrụ ndụ akụrụ. O nwere ike ibute akụrụ akụrụ.

Glomerulonephritis bụ mbufụt nke glomeruli. The glomeruli nke akụrụ aka nyo ihe mkpofu na mmiri mmiri site na ọbara na-aghọ mmamịrị.

Membranoproliferative glomerulonephritis (MPGN) bụ ụdị nke glomerulonephritis nke mmeghachi omume na-adịghị mma. Ngwọta nke ihe na-alụso ọrịa ọgụ na-ewu n'akụkụ nke akụrụ a na-akpọ akpụkpọ ahụ okpuru ala nke na-atọ ụtọ. Akpụkpọ a na - enyere aka nzacha ihe mkpofu na mmiri mmiri ọzọ na ọbara.

Mmebi nke akpụkpọ ahụ na-emetụta ike akụrụ iji mepụta mmamịrị n'ụzọ kwesịrị ekwesị. O nwere ike ikwe ka ọbara na protein baa n’ime mmamịrị. Ọ bụrụ na protein zuru ezu na-amaba na mmamịrị, mmiri nwere ike isi na arịa ọbara na-apụta n'ime anụ ahụ, na-eduga na ọzịza (edema). Ngwongwo nitrogen nwekwara ike ibute n'ime ọbara (azotemia).

2dị 2 nke ọrịa a bụ MPGN I na MPGN II.

Imirikiti ndị nwere ọrịa nwere ụdị I. MPGN II dị obere. Ọ na-akawanye njọ karịa MPGN I.

Ihe kpatara MPGN nwere ike ịgụnye:

• Ọrịa autoimmune (systemic lupus erythematosus, scleroderma, Sjögren syndrome, sarcoidosis)
• Ọrịa cancer (leukemia, lymphoma)
• Ọrịa (ịba ọcha n'anya B, ịba ọcha n'anya C, endocarditis, ịba)

Mgbaàmà nwere ike ịgụnye nke ọ bụla n'ime ihe ndị a:

• Ọbara na mmamịrị
• Mgbanwe ọnọdụ ọnọdụ uche dị ka mbelata ịmụrụ anya ma ọ bụ mgbatị ebelata
• Igwe ojii ojii
• Mmiri mamịrị (anwụrụ ọkụ, cola, ma ọ bụ tii nwere agba)
• Mbelata nke mamịrị
• Ọzịza nke akụkụ ahụ ọ bụla

Onye nlekọta ahụike ga-enyocha gị wee jụọ maka ihe mgbaàmà gị. Onye ahụ na-eweta ọrụ nwere ike ịchọpụta n’inwe ihe ịrịba ama nke nnukwu mmiri n’ime ahụ, dị ka:

• Ọzịza, mgbe mgbe na ụkwụ
• Ọdịiche na-adịghị mma mgbe ị na-ege stethoscope na-ege obi gị na ngụgụ ume
• I nwere ike inwe ọbara mgbali elu

Ule ndị a na-enyere aka ikwenye nchoputa ahụ:

• BUN na ọbara ọbara creatinine
• Ọbara agbakwunye ọbara
• Urinalysis
• Mmamịrị fitsin
• Akụrụ biopsy (iji gosi na membranoproliferative GN I or II)

Ọgwụgwọ dabere na mgbaàmà ya. Ebumnuche nke ọgwụgwọ bụ iji belata mgbaàmà, gbochie nsogbu, ma belata ọganihu nke nsogbu ahụ.

Enwere ike ịgbanwe mgbanwe nri gị. Nke a nwere ike ịgụnye ịmachi sodium, mmiri mmiri, ma ọ bụ protin iji nyere aka ịchịkwa ọbara mgbali elu, ọzịza, na ịkọpụta ihe ndị na-emebi ihe n’ọbara.

Ọgwụ nwere ike ịkọwa gụnyere:

• Ọbara mgbali elu
• Dipyridamole, ma ọ bụ na-enweghị ọgwụ mgbu
• Diurek
• Ọgwụ iji gbochie usoro ahụ ji alụso ọrịa ọgụ, dị ka cyclophosphamide
• Steroid

Ọgwụgwọ dị irè karịa ụmụaka karịa nke ndị okenye. O nwere ike ịdị mkpa ka ịrịa ọrịa akụrụngwa ma ọ bụ ịkpụgharị akụrụ iji jikwaa akụrụ.

Nsogbu a na-eji nwayọọ nwayọọ na-akawanye njọ ma na-ebute ọdịda akụrụ na-adịghị ala ala.

Ọkara ndị mmadụ nwere nsogbu a na - amalite ịrịa ọrịa ogologo oge (adịghị ala ala) n’ime afọ iri. Nke a yikarịrị ka ndị nwere protein dị elu na mmamịrị ha.

Nsogbu ndị nwere ike ibute ọrịa a gụnyere:

• Ọrịa nephritic dị ukwuu
• Nnukwu akụrụ odida
• Ọrịa akụrụ na-adịghị ala ala

Kpọọ oge ọhụhụ na onye na-eweta gị ma ọ bụrụ:

• Have nwere ihe mgbaàmà nke ọnọdụ a
• Ihe mgbaàmà gị na-akawanye njọ ma ọ bụ ghara ịla
• Develop na-ewepụta mgbaàmà ọhụụ, gụnyere mbelata mmamịrị gị

Igbochi oria dika ịba ọcha n'anya ma ọ bụ ijikwa ọrịa dịka lupus nwere ike inye aka gbochie MPGN.

Membranoproliferative GN M; Membranoproliferative GN II; Mesangiocapillary glomerulonephritis; Membranoproliferative glomerulonephritis; Lobular GN; Glomerulonephritis - membranoproliferative; MPGN pịnye m; MPGN ụdị II

• Akụrụ anatomi

Roberts ISD. Ọrịa akụrụ. Na: Cross SS, ed. Underwood's Pathology: Nlekọta Ahụike. Nke 7. Philadelphia, PA: Elsevier; 2019: isi 21.

Saha MK, Pendergraft WF, Jennette JC, Falk RJ. Ọrịa glomerular bụ isi. Na: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner na Rector nke akụrụ. Nke 11. Philadelphia, PA: Elsevier; 2020: isi 31.

Nhazi S, De Vriese AS, Fervenza FC. Membranoproliferative glomerulonephritis na cryoglobulinemic glomerulonephritis. Na: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Comprehensive Clinical Nephrology. Nke isii. Philadelphia, PA: Elsevier; 2019: isi 21.