Nyocha DNA na-enweghị Prenatal

Ndinaya

• Kedu ihe nyocha DNA (cfDNA) nke na-enweghị mkpụrụ ndụ?
• Kedu ihe eji eme ihe?
• Kedu ihe kpatara m ji chọọ nyocha cfDNA tupu oge eruo?
• Kedu ihe na - eme n'oge nyocha nke cfDNA tupu oge eruo?
• Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule a?
• Onwere ihe egwu di n’ule a?
• Kedu ihe nsonaazụ ahụ pụtara?
• Onwere ihe ozo m choro ima banyere pfrensis cfDNA screening?
• Ntughari

Kedu ihe nyocha DNA (cfDNA) nke na-enweghị mkpụrụ ndụ?

Nyocha DNA (cfDNA) na-enweghị obere nwa bụ ule ọbara maka ụmụ nwanyị dị ime. N'ime afọ ime, ụfọdụ DNA dị n'ime nwa na-agagharị n'ọbara ọbara nne. Nyocha cfDNA na-enyocha DNA a iji chọpụta ma nwatakịrị nwere ike ịda ọrịa Down ma ọ bụ nsogbu ọzọ nke trisomy kpatara.

A trisomy bụ nsogbu nke chromosomes. Chromosomes bụ akụkụ nke mkpụrụ ndụ gị nke nwere mkpụrụ ndụ ihe nketa gị. Mkpụrụ ndụ ihe nketa bụ akụkụ nke DNA sitere n’aka nne gị na nna gị. Ha na-ebu ozi na-ekpebi àgwà gị pụrụ iche, dịka ịdị elu na agba anya.

• Ndị mmadụ na - ejikarị kromosome iri anọ na isii, kee ụzọ iri abụọ na atọ, na sel ọ bụla.
• Ọ bụrụ na otu n’ime ụzọ abụọ a nwere akwụkwọ ọzọ nke chromosome, a na-akpọ ya trisomy. A trisomy na-ebute mgbanwe n'ụzọ ahụ na ụbụrụ na-etolite.
• Na Down syndrome, enwere ihe ozo nke chromosome 21. Nke a makwaara dị ka trisomy 21. Down syndrome bụ ọrịa chromosome kachasị na United States.
• Nsogbu ndi ozo nke trisomy bu oria Edwards (trisomy 18), ebe enwere ihe ozo nke chromosome 18, na Patau syndrome (trisomy 13), ebe enwere ihe ozo chromosome 13. Nsogbu ndi a di obere ma karie nsogbu Down Down. Imirikiti ụmụ ọhụrụ nwere trisomy 18 ma ọ bụ trisomy 13 na-anwụ n'ime afọ mbụ nke ndụ.

Nyocha cfDNA nwere obere ihe ize ndụ nye gị na nwa gị, mana ọ nweghị ike ịgwa gị n'ezie ma nwa gị ọ nwere nsogbu chromosome. Onye nlekọta ahụike gị kwesiri ịtụ ule ndị ọzọ iji kwado ma ọ bụ wepu nchoputa.

Aha ndị ọzọ: nwa ebu n’afọ na-enweghị mkpụrụ ndụ DNA, cffDNA, nnwale tupu ịmụ nwa amụtaghị nwa, NIPT

Kedu ihe eji eme ihe?

A na-ejikarị nyochaa cfDNA iji gosi ma nwa ị na-amụbeghị amụbawanye ohere maka otu n'ime nsogbu chromosome ndị a:

• Ọrịa ala (trisomy 21)
• Ọrịa Edwards (trisomy 18)
• Ọrịa Patau (trisomy 13)

Enwere ike iji nyocha ahụ:

• Kpebisie ike na okike nwa (nwoke na nwanyị). Enwere ike ime nke a ma ọ bụrụ na ultrasound gosipụtara na akụkụ ahụ nwa abụghị nwoke ma ọ bụ nwanyị n'ụzọ doro anya. Nke a nwere ike ịbụ nsogbu nke chromosomes mmekọahụ.
• Lelee ụdị ọbara Rh. Rh bụ protein dị na mkpụrụ ndụ ọbara uhie. Ọ bụrụ na ị nwere protein ahụ, a na-ewere gị dị ka ihe ọma Rh. Ọ bụrụ na i meghị, ị bụ Rh na-adịghị mma. Ọ bụrụ na ị bụ Rh na-adịghị mma na nwa e bu n’afọ bụ Rh nti, usoro ahụ gị ji alụ ọgụ nwere ike ibuso mkpụrụ ndụ ọbara nwa gị ọgụ. Ọ bụrụ n'ịchọpụta na ị na-adịghị ahụkebe Rh n'oge ị dị ime, ịnwere ike ị medicinesụ ọgwụ iji chebe nwa gị pụọ na nsogbu dị egwu.

Enwere ike ime nyocha cfDNA dika izu nke iri nke ime ime.

Kedu ihe kpatara m ji chọọ nyocha cfDNA tupu oge eruo?

Ọtụtụ ndị na-ahụ maka ahụike na-atụ aro nyocha a maka ụmụ nwanyị dị ime bụ ndị nwere nnukwu nsogbu ịmụ nwa nwere ọrịa chromosome. Nwere ike nọrọ n'ihe ize ndụ dị elu karị ma ọ bụrụ:

• Are dị afọ 35 ma ọ bụ karịa. Afọ nne bụ ihe mbụ na-ebute nsogbu ịmụ nwa nwere nsogbu Down syndrome ma ọ bụ ọrịa trisomy ndị ọzọ. Ihe ize ndụ na-abawanye ka nwanyị na-eme agadi.
• Nweela nwa ọzọ nwere nsogbu kromosome.
• Ultrasound nwa gị n’afọ adịchaghị mma.
• Nsonaazụ nnwale tupu ọmụmụ nwa amabaghị.

Fọdụ ndị na-ahụ maka ahụike na-atụ aro ka enyocha ndị inyom niile dị ime. Nke a bụ n'ihi na ọ fọrọ nke nta ka nyocha ahụ enweghị ihe ize ndụ ma nwee oke izi ezi nke dị elu ma e jiri ya tụnyere ule nyocha ọhụụ ndị ọzọ.

Gị na onye nlekọta ahụike gị kwesiri ikwurịta ma ọ bụrụ na nyocha cfDNA dị gị mma.

Kedu ihe na - eme n'oge nyocha nke cfDNA tupu oge eruo?

Onye ọkachamara ahụike ga-ewere ihe nyocha ọbara site na akwara aka gị, jiri obere agịga. Mgbe etinyere agịga ahụ, a ga-achịkọta obere ọbara n'ime ule nyocha ma ọ bụ vial. Nwere ike na-eche ntakịrị ihe mgbe agịga na-abanye ma ọ bụ na-apụta. Nke a na-ewe ihe na-erughị nkeji ise.

Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule a?

Nwere ike ịgwa onye na-enye ndụmọdụ gbasara mkpụrụ ndụ ihe nketa okwu tupu a nwalee gị. Onye ndụmọdụ banyere mkpụrụ ndụ ihe nketa bụ ọkachamara a zụrụ azụ na mkpụrụ ndụ ihe nketa na ule mkpụrụ ndụ. Ọ nwere ike ịkọwapụta nsonaazụ ndị nwere ike ịpụta na ihe ọ nwere ike ịpụta gị na nwa gị.

Onwere ihe egwu di n’ule a?

Onweghi ihe ize ndụ diri nwa ebu n’afọ ma obere ihe egwu diri gị. May nwere ike ịnwe obere ihe mgbu ma ọ bụ mmerụ ahụ ebe etinyere agịga ahụ, mana ọtụtụ mgbaàmà na-apụ ngwa ngwa.

Kedu ihe nsonaazụ ahụ pụtara?

Ọ bụrụ na nsonaazụ gị adịghị mma, o yighị ka nwa gị ọ nwere ọrịa Down ma ọ bụ ọrịa trisomy ọzọ. Ọ bụrụ na nsonaazụ gị dị mma, ọ pụtara na enwere nsogbu dị ukwuu na nwa gị nwere otu n'ime nsogbu ndị a. Mana ọ nweghị ike ịgwa gị n’ezie ma ọ bụrụ na emetụta nwa gị. Maka nyocha ọzọ enwetara, ị ga-achọ nyocha ndị ọzọ, dịka amniocentesis na chorionic villus sampling (CVS). Ule ndị a na-abụkarị usoro dị oke nchekwa, mana ha nwere obere ihe kpatara ibute ọpụpụ.

Ọ bụrụ na ị nwere ajụjụ gbasara nsonaazụ gị, gwa ndị ọrụ ahụike gị na / ma ọ bụ onye ndụmọdụ mkpụrụ ndụ ihe nketa.

Mụtakwuo maka ule nyocha ụlọ, akara ngosi, na nghọta nsonaazụ.

Onwere ihe ozo m choro ima banyere pfrensis cfDNA screening?

Nyocha cfDNA ezighi ezi na ụmụ nwanyị dị ime karịa otu nwa (ejima, atọ ma ọ bụ karịa).

Ntughari

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Ejila ozi dị na saịtị a dị ka onye dochie anya nlekọta ahụike ọkachamara ma ọ bụ ndụmọdụ. Kpọtụrụ onye na-ahụ maka ahụike ma ọ bụrụ na ị nwere ajụjụ gbasara ahụike gị.