Ọdịnihu Research na Clinical Ọnwụnwa maka Primary Ọganihu MS

Ndinaya

• Nchịkọta
• MSdị MS
• Ghọta MS na-aga n'ihu
• Ọgwụ PPMS
• Ocrevus (Ocrelizumab)
• PPMS na-aga n'ihu na-anwale ọnwụnwa
• NurOwn na-agwọ ọrịa sel
• Biotin
• Masitinib
• Emechara ule ahụike
• Ibudilast
• Idebenone
• Laquinimod
• Fampridine
• PPMS nyocha
• Wepu

Nchịkọta

Multiple sclerosis (MS) bụ ọnọdụ autoimmune na-adịghị ala ala. Ọ na - eme mgbe ahụ malitere ịwakpo akụkụ nke sistem ụjọ (CNS).

Imirikiti ọgwụ na ọgwụgwọ ugbu a na-elekwasị anya na MS na-alaghachi ma ọ bụghị na MS na-aga n'ihu (PPMS). Agbanyeghị, a na-anwale ọnwụnwa iji nyere aka ịghọta PPMS nke ọma yana ịchọta ọgwụgwọ ọhụrụ, dị mma.

MSdị MS

Isi MS bụ ihe anọ dị mkpa:

• ọrịa na-arịa ọrịa na-adịghị ahụkebe (CIS)
• nlọghachi-enye MS (RRMS)
• isi na-aga n'ihu MS (PPMS)
• Nke abụọ na-aga n'ihu MS (SPMS)

Emepụtara ụdị MS ndị a iji nyere ndị nchọpụta ahụike aka ịkọwapụta ndị na-eme ụlọ ọgwụ na-arịa ụdị ọrịa ahụ. Ndị otu a na-enye ndị na-eme nchọpụta nyocha ịdị irè na nchekwa nke ọgwụgwọ ụfọdụ na-enweghị iji ọnụ ọgụgụ buru ibu nke ndị sonyere.

Ghọta MS na-aga n'ihu

Naanị pasent 15 ma ọ bụ karịa nke ndị niile achọpụtara na MS nwere PPMS. PPMS na-emetụta ụmụ nwoke na ụmụ nwanyị nha anya, ebe RRMS dịkarịsịrị na ụmụ nwanyị karịa ụmụ nwoke.

Imirikiti ụdị MS na-eme mgbe usoro ahụ ji alụso ọrịa ọgụ na-awakpo n'ọbọ myelin. The myelin n'ọbọ bụ abụba, echebe ihe na gburugburu akwara na ọgidigi azụ na ụbụrụ. Mgbe a wakporo ihe a, ọ na-ebute mbufụt.

PPMS na-eduga na mmebi akwara na anụ ahụ dị nro na mpaghara ndị mebiri emebi. Ọrịa ahụ na-agbagha usoro nke nkwukọrịta akwara, na-akpata usoro a na-atụghị anya ya nke mgbaàmà na ọrịa na-aga n'ihu.

N'adịghị ka ndị nwere RRMS, ndị nwere PPMS na-enwewanye ọrụ na-akawanye njọ na-enweghị nlọghachi azụ ma ọ bụ ndapụta n'oge. Na mgbakwunye na mmụba nke nwayọ nwayọ, ndị nwere PPMS nwekwara ike ịnwe mgbaàmà ndị a:

• a sensashion nke numbness ma ọ bụ tingling
• ike ọgwụgwụ
• nsogbu na ịga ije ma ọ bụ site na nhazi mmegharị
• nsogbu na ọhụụ, dị ka ọhụụ abụọ
• nsogbu na ncheta na mmụta
• akwara ma ọ bụ nkwarụ akwara
• mgbanwe na ọnọdụ

Ọgwụ PPMS

Gwọ PPMS siri ike karịa ịgwọ RRMS, ọ gụnyere iji usoro ọgwụgwọ immunosuppressive. Usoro ọgwụgwọ a na-enye naanị enyemaka nwa oge. Enwere ike iji ha mee ihe n'enweghị nsogbu ma na - aga n'ihu n'ihu ọnwa ole na ole ruo otu afọ n'otu oge.

Ọ bụ ezie na nchịkwa nri na ọgwụ ọjọọ (FDA) akwadoro ọtụtụ ọgwụ maka RRMS, ọ bụghị ha niile kwesịrị ekwesị maka ụdị MS na-aga n'ihu. A na-ewere ọgwụ RRMS, nke a makwaara dị ka ọgwụ na-agbanwe ọrịa (DMDs) mgbe niile ma na-enwekarị mmetụta ndị a na-apụghị ịnagide.

Enwekwara ike ịhụ ọnya na-akpata mmerụ ahụ na mmebi akwara na ndị nwere PPMS. Ihe ọnya ndị ahụ na-emetụta nke ukwuu ma nwee ike ibute ihe mkpuchi myelin. Ọ bụ ugbu a edoghị ma ọgwụ ibelata mbufụt nwere ike jiri nwayọọ na-enwe ụdị nke MS.

Ocrevus (Ocrelizumab)

FDA kwadoro Ocrevus (ocrelizumab) dị ka ọgwụgwọ maka RRMS na PPMS na Machị 2017. Ka ọ dị ugbu a, ọ bụ naanị ọgwụ ọgwụ FDA ka akwadoro ịgwọ PPMS.

Ọnwụnwa ahụike na-egosi na ọ nwere ike ibelata ọganihu nke mgbaàmà na PPMS site na gburugburu 25 pasent ma e jiri ya tụnyere placebo.

A kwadoro Ocrevus maka ọgwụgwọ RRMS na "mmalite" PPMS na England. A kabetabeghị ya n'akụkụ ndị ọzọ nke United Kingdom.

National Institute for Health Excellence (NICE) jụrụ Ocrevus na mbido na ego iji nye ya karịrị uru ya. Agbanyeghị, NICE, National Health Service (NHS), na onye na-emepụta ọgwụ (Roche) mechara tụgharịa ọnụ ahịa ya.

PPMS na-aga n'ihu na-anwale ọnwụnwa

Ihe dị mkpa maka ndị na-eme nchọpụta bụ ịmụtakwu banyere ụdị MS na-aga n'ihu. Ọgwụ ọhụrụ ga-agabiga ule nyocha tupu FDA akwadoro ha.

Ọtụtụ ọnwụnwa na-adaba na 2 ruo afọ 3. Otú ọ dị, n'ihi na nchọpụta ahụ dị oke, ọbụlagodi ọnwụnwa dị mkpa maka PPMS. A na-eduzi ule RRMS ndị ọzọ n'ihi na ọ dị mfe ikpe ikpe maka ọgwụgwọ ọgwụ na nlọghachi.

Hụ ebe nrụọrụ weebụ National Multiple Sclerosis Society maka ndepụta zuru oke nke ọnwụnwa ahụike na United States.

Nlere ule ndi a na - aga n’ihu ugbu a.

NurOwn na-agwọ ọrịa sel

Brainstorm Cell Therapeutics na-arụ usoro nke ụlọ ọgwụ II iji nyochaa nchekwa na ịdị irè nke mkpụrụ ndụ NurOwn na ọgwụgwọ MS na-aga n'ihu. Usoro ọgwụgwọ a na-eji sel sel ewepụtara sitere na ndị sonyere na-akpali akpali iji mepụta ihe ụfọdụ na-eto eto.

Na Nọvemba 2019, National Multiple Sclerosis Society nyere Brainstorm Cell Therapeutics onyinye nyocha $ 495,330 iji kwado nkwado a.

A na-atụ anya ikpe ikpe a na September 2020.

Biotin

MedDay Pharmaceuticals SA na-arụ ọrụ nke oge III n'ụlọ ikpe maka ịdị irè nke nnukwu ọgwụ biotin na-agwọ ndị nwere MS na-aga n'ihu. Ikpe a na-achọkwa ilekwasị anya na ndị nwere nsogbu gait.

Biotin bụ vitamin nke metụtara na-emetụta ihe ndị na-akpata cellular yana mmepụta myelin. A na-atụle capsule biotin na placebo.

Ikpe ahụ anaghịzi anata ndị ọhụrụ, mana atụghị anya na ọ ga-akwụsị rue June 2023.

Masitinib

AB Science na-eme usoro nyocha nke III na ọgwụ masitinib. Masitinib bụ ọgwụ na-egbochi nzaghachi mbufụt. Nke a na - eduga na nzaghachi dị ala na obere nsị.

Ikpe a na-enyocha nchekwa na ịdị irè nke masitinib ma e jiri ya tụnyere placebo. A na-eji usoro ọgwụgwọ abụọ nke masitinib atụnyere placebo: Usoro nke mbụ na-eji otu usoro onunu ogwu ahụ dum, ebe nke ọzọ na-agụnye nha nha nha mgbe ọnwa 3 gachara.

Ikpe a anaghịzi ewere ndị ọhụrụ. A na-atụ anya ịkwụsị na Septemba 2020.

Emechara ule ahụike

Emechara ule ndị a na nso nso a. Maka ọtụtụ n'ime ha, ebipụtara nsonaazụ mbụ ma ọ bụ nke ikpeazụ.

Ibudilast

MediciNova emechaala usoro ọgwụgwọ nke abụọ na ọgwụ ibudilast. Ebumnuche ya bụ ịchọpụta nchekwa na ọrụ nke ọgwụ na ndị nwere MS na-aga n'ihu. N'ime ọmụmụ ihe a, a tụnyere ibudilast na placebo.

Nchoputa ihe omumu mbu gosiputara na ibudilast mere ka obughari nke ụbụrụ ghara idi ya ma e jiri ya tụnyere placebo n'ime oge 96-izu. Mmetụta ndị kachasị emetụta bụ ihe mgbaàmà nke eriri afọ.

Ọ bụ ezie na nsonaazụ na-ekwe nkwa, achọrọ nyocha ndị ọzọ iji hụ ma a ga - emepụtakwa nsonaazụ nke ikpe a yana otu ibudilast nwere ike iji tụnyere Ocrevus na ọgwụ ndị ọzọ.

Idebenone

National Institute of Allergy and Infectious Diseases (NIAID) mechara rụchaa usoro ọgwụgwọ I / II na-agwọ ọrịa iji nyochaa mmetụta idebenone nwere n'ahụ ndị nwere PPMS. Idebenone bụ ụdị sịntetik nke coenzyme Q10. Ekwenyere na ọ ga-ejedebe mmebi nke usoro ụjọ ahụ.

N'ime oge afọ 2 ikpeazụ a nke ikpe afọ 3 a, ndị sonyere were ọgwụ ahụ ma ọ bụ placebo. Nsonaazụ mbido gosipụtara na, n'oge ọmụmụ ahụ, idebenone enyeghị uru ọ bụla na placebo.

Laquinimod

Valọ ọrụ na-ere ọgwụ na Teva kwadoro ọmụmụ ihe nke abụọ na mbọ iji guzobe ihe akaebe nke echiche maka ịgwọ PPMS na laquinimod.

Aghọtachaghị otú laquinimod si arụ ọrụ. Ekwenyere na ọ na-agbanwe omume nke mkpụrụ ndụ na-enweghị ihe mgbochi, ya mere na-egbochi mmebi usoro ụjọ.

Nsonaazụ nnwale ọnwụnwa emeela ka onye nrụpụta ya, Active Biotech, kwụsị mmepe nke laquinimod dịka ọgwụ maka MS.

Fampridine

Na 2018, Mahadum College Dublin dechara ikpe nke anọ iji nyochaa mmetụta nke fampridine na ndị nwere nkwarụ ụkwụ na elu ma PPMS ma ọ bụ SPMS. Fampridine makwaara dị ka dalfampridine.

Ọ bụ ezie na ikpe a mechara, ọ nweghị nsonaazụ ndị a kọrọ.

Agbanyeghị, dị ka nchọpụta nke Italiantali nke 2019, ọgwụ ahụ nwere ike isi melite ọsọ ọsọ na ndị nwere MS. Nyochaa 2019 na meta-analysis kwubiri na e nwere ihe akaebe siri ike na ọgwụ ahụ mere ka ikike nke ndị nwere MS jee ije dị mkpirikpi yana ike ije ije ha ghọtara.

PPMS nyocha

National Multiple Sclerosis Society na-akwalite nyocha na-aga n'ihu na ụdị MS na-aga n'ihu. Ebumnuche bụ ịmepụta ọgwụgwọ na-aga nke ọma.

Researchfọdụ nyocha elebara anya na ọdịiche dị n'etiti ndị nwere PPMS na ndị nwere ahụike. Nnyocha e mere na nso nso a gosiri na mkpụrụ ndụ mkpụrụ ndụ dị n'ụbụrụ nke ndị nwere PPMS dị ka okenye karịa otu mkpụrụ ndụ mkpụrụ ndụ ndị ahụ nwere ahụ ike.

Ọzọkwa, ndị nchọpụta ahụ chọpụtara na mgbe oligodendrocytes, mkpụrụ ndụ ndị na-emepụta myelin, kpughere na sel ndị a, ha gosipụtara protein dị iche iche karịa ndị nwere ahụike. Mgbe okwuchi protein a gbochiri, ndị oligodendrocytes na-eme ihe kwesiri. Nke a nwere ike inye aka kọwaa ihe kpatara myelin ji nwee nsogbu n'ime ndị nwere PPMS.

Nnyocha ọzọ chọpụtara na ndị nwere MS na-aga n'ihu nwere obere irighiri ihe ndị a na-akpọ bile acids. Bile acids nwere ọtụtụ ọrụ, ọkachasị na mgbaze. Ha nwekwara mmetụta mgbochi mkpali na mkpụrụ ndụ ụfọdụ.

Achọpụtakwara ndị nabatara acid bile na sel na anụ ahụ MS. Echere na mgbakwunye na acid bile nwere ike ịbara ndị mmadụ uru na MS na-aga n'ihu. N'ezie, ikpe ụlọ ọgwụ iji nwalee nke a na-aga n'ihu ugbu a.

Wepu

Italslọ ọgwụ, mahadum, na ụlọ ọrụ ndị ọzọ na United States na-arụ ọrụ na-aga n'ihu ịmụtakwu banyere PPMS na MS n'ozuzu.

Ruo ugbu a naanị otu ọgwụ, Ocrevus, ka FDA kwadoro maka ọgwụgwọ PPMS. Ọ bụ ezie na Ocrevus na-ebelata ọganihu nke PPMS, ọ kwụsịghị ọganihu ahụ.

Drugsfọdụ ọgwụ ọjọọ, dị ka ibudilast, na-eyi nke na-ekwe nkwa dabere na nnwale izizi. Ọgwụ ndị ọzọ, dị ka idebenone na laquinimod, egosighi na ha dị irè.

A chọrọ ule ndị ọzọ iji chọpụta usoro ọgwụgwọ ndị ọzọ maka PPMS. Jụọ onye na-elekọta ahụike gị gbasara nnwale ụlọ ọgwụ kachasị ọhụrụ na nyocha nwere ike ịbara gị uru.