BCR ABL Nnwale Ọrịa

Ndinaya

• Kedu ihe bụ ule mkpụrụ ndụ BCR-ABL?
• Kedu ihe eji ya?
• Kedu ihe kpatara m ji chọọ nyocha mkpụrụ ndụ BCR-ABL?
• Kedu ihe na-eme n'oge ule mkpụrụ ndụ BCR-ABL?
• Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?
• Onwere ihe egwu di n’ule a?
• Kedu ihe nsonaazụ ahụ pụtara?
• Enwere ihe ọ bụla ọzọ m kwesịrị ịma gbasara nyocha mkpụrụ ndụ ihe nketa BCR-ABL?
• Ntughari

Kedu ihe bụ ule mkpụrụ ndụ BCR-ABL?

Nnyocha mkpụrụ ndụ nke BCR-ABL na-achọ mgbanwe mkpụrụ ndụ (mgbanwe) na chromosome ụfọdụ.

Chromosomes bụ akụkụ nke mkpụrụ ndụ gị nke nwere mkpụrụ ndụ ihe nketa gị. Mkpụrụ ndụ ihe nketa bụ akụkụ nke DNA sitere n’aka nne gị na nna gị. Ha na-ebu ozi na-ekpebi àgwà gị pụrụ iche, dịka ịdị elu na agba anya.

Ndị mmadụ na - ejikarị kromosome iri anọ na isii, kee ụzọ iri abụọ na atọ, na sel ọ bụla. Otu n’ime chromosome ọ bụla sitere na nne gị, nke ọzọ abụrụ site na nna gị.

BCR-ABL bụ mmụba nke sitere na njikọta nke mkpụrụ ndụ ihe nketa abụọ, nke a maara dị ka BCR na ABL. A na - akpọ ya mgbe ụfọdụ fusion gene.

• Mkpụrụ ndụ BCR na-ejikarị nọmba chromosome 22.
• Mkpụrụ ndụ ABL na-ejikarị nọmba chromosome 9.
• Mgbanwe BCR-ABL na-eme mgbe mpempe mkpụrụ ndụ BCR na ABL kwụsịrị ma gbanwee ebe.
• Mgbanwe ahụ gosipụtara na chromosome 22, ebe mpempe chromosome 9 jikọtara onwe ya.
• A na-akpọ chromosome 22 a na-akpọ chromosome Philadelphia n’ihi na nke ahụ bụ obodo ebe ndị nchọpụta bu ụzọ chọpụta ya.
• Mkpụrụ ndụ BCR-ABL abụghị ụdị ngbanwe nke nne na nna gị ketara. Ọ bụ ụdị mgbanwe mgbanwe somatic, nke pụtara na amughi gị na ya. Nweta ya ma emechaa.

Mkpụrụ ndụ BCR-ABL na-egosi ndị ọrịa nwere ụdị ọrịa kansa kansa ụfọdụ, ọrịa kansa nke ụmị ọkpụkpụ na mkpụrụ ndụ ọbara ọcha. A na-ahụ BCR-ABL n'ihe fọrọ nke nta ka ọ bụrụ ndị ọrịa niile nwere ụdị ọrịa kansa ọbara a na-akpọ leukemia myeloid na-adịghị ala ala (CML). Aha ọzọ maka CML adịghị ala ala mmachi leukemia. Aha abụọ a na-ezo aka n'otu ọrịa.

A na-ahụkwa mkpụrụ ndụ BCR-ABL na ụfọdụ ndị ọrịa nwere ụdị ọrịa leukemia lymphoblastic buru ibu (ALL) yana ọ dịkarịghị na ndị ọrịa nwere ọrịa leukemia myelogenous dị ukwuu (AML).

Medicinesfọdụ ọgwụ cancer na-arụ ọrụ nke ọma n'ịgwọ ndị ọrịa leukemia na mmụba mkpụrụ ndụ BCR-ABL. Ọgwụ ndị a nwekwara mmetụta dị ole na ole karịa ọgwụgwọ ọrịa cancer ndị ọzọ. Otu ọgwụ ndị ahụ adịghị arụ ọrụ n’ịgwọ ụdị ọrịa kansa ọbara dị iche iche ma ọ bụ ọrịa cancer ndị ọzọ.

Aha ndị ọzọ: BCR-ABL1, BCR-ABL1 njikọ, Philadelphia chromosome

Kedu ihe eji ya?

A na-ejikarị ule BCR-ABL achọpụta ma ọ bụ wepụ ọrịa leukemia na-adịghị ala ala (CML) ma ọ bụ otu ụdị ụdị ọrịa leukemia lymphoblastic buru ibu (ALL) nke a na-akpọ Ph-positive ALL. Achọpụtara Ph-positive pụtara chromosome Filadelfia. A naghị eji ule ahụ achọpụta ụdị ọrịa leukemia ndị ọzọ.

Ule ahụ nwekwara ike iji:

• Hụ ma ọgwụgwọ ọrịa kansa ọ dị mma.
• Hụ ma ọ bụrụ na onye ọrịa etolitela ọgwụgwọ ụfọdụ. Nke ahụ pụtara na ọgwụgwọ nke na-adịbu arụ ọrụ anaghịzi arụ ọrụ.

Kedu ihe kpatara m ji chọọ nyocha mkpụrụ ndụ BCR-ABL?

Nwere ike ịchọ nyocha BCR-ABL ma ọ bụrụ na ị nwere mgbaàmà nke ọrịa leukemia myeloid na-adịghị ala ala (CML) ma ọ bụ Ph-positive nnukwu lymphoblastic leukemia (ALL). Ndị a gụnyere:

• Ike ọgwụgwụ
• Ahụ ọkụ
• Iwetulata ibu
• Abalị sweats (oké sweating mgbe ị na-ehi ụra)
• Nkwonkwo ma ọ bụ ọkpụkpụ mgbu

Fọdụ ndị nwere CML ma ọ bụ Ph-nti ALL enweghị mgbaàmà, ma ọ bụ ihe mgbaàmà dị nro, ọkachasị n'oge mbido ọrịa ahụ. Ya mere onye nlekọta ahụike gị nwere ike ịnye nyocha a ma ọ bụrụ na nyocha ọbara zuru oke ma ọ bụ nyocha ọbara ọzọ gosipụtara nsonaazụ ndị na-adịghị adị. Ikwesiri ime ka onye na-eweta gị mara ma ọ bụrụ na ị nwere mgbaàmà ọ bụla metụtara gị. CML na Ph-nti ALL dị mfe ịgwọ mgbe achọtara n'oge.

Nwekwara ike ịchọ ule a ma ọ bụrụ na a na-agwọ gị ugbu a maka CML ma ọ bụ Ph-positive ALL. Nnwale ahụ nwere ike inyere onye na-eweta gị aka hụ ma ọgwụgwọ gị ọ na-arụ ọrụ.

Kedu ihe na-eme n'oge ule mkpụrụ ndụ BCR-ABL?

Nnwale BCR-ABL na-abụkarị nyocha ọbara ma ọ bụ usoro a na-akpọ agụụ ụmị ọkpụkpụ na biopsy.

Ọ bụrụ n’ịnwale ule ọbara, onye okacha amara nke ahuike ga ewere obara site na akwara na ogwe aka gi. Mgbe etinyere agịga ahụ, a ga-achịkọta obere ọbara n'ime ule nyocha ma ọ bụ vial. Nwere ike na-eche ntakịrị ihe mgbe agịga na-abanye ma ọ bụ na-apụta. Nke a na-ewe ihe na-erughị nkeji ise.

Ọ bụrụ na ị na-enweta ụmị ọkpụkpụ na biopsy, usoro gị nwere ike ịgụnye usoro ndị a:

• Ga-edina ala n'akụkụ gị ma ọ bụ afọ gị, dabere na ọkpụkpụ a ga-eji nyocha. Imirikiti ule na-agbaji ọkpụkpụ na-ewepụ ọkpụkpụ úkwù.
• A ga-eji akwa kpuchie ahụ gị, nke mere na naanị mpaghara a na-anwale ule na-egosi.
• A ga-eji antiseptik kpochaa saịtị ahụ.
• Ga-enweta ogwu ogwu nke ọgwụ na-agwụ ike. Ọ nwere ike gbaa agba.
• Ozugbo mpaghara ahụ dara ụda, onye nlekọta ahụike ga-ewere ihe nlele ahụ. Ga-agha ụgha nke ukwuu n'oge ule a.
  • Maka ebumnuche ụmị ọkpụkpụ, nke a na-ebu ụzọ eme, onye na-ahụ maka ahụike ga-etinye agịga site na ọkpụkpụ wee wepụta mmiri ụmị ọkpụkpụ na sel. Nwere ike ịnwe ihe mgbu dị nkenke ma dị nkenke mgbe etinyere agịga ahụ.
  • Maka biopsy biopsy, onye nlekọta ahụike ga-eji ngwá ọrụ pụrụ iche nke na-agbagọ n'ime ọkpụkpụ iji wepụta ihe nlele nke anụ ahụ. May nwere ike ịnwe nrụgide na saịtị ahụ ka a na-ewere sample ahụ.
• Ọ na-ewe ihe dị ka nkeji iri iji mee ule abụọ ahụ.
• Mgbe ule ahụ gasịrị, onye nlekọta ahụike ga-ekpuchi bandage na saịtị.
• Mee atụmatụ ime ka mmadụ kwọọrọ gị laa n'ụlọ, ebe ọ bụ na a pụrụ inye gị ọgwụ na-eme ka ahụ da gị ụra tupu a nwalee gị, nke pụrụ ime ka ị na-ero ụra.

Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?

Usually naghị achọ nkwadebe pụrụ iche maka ọbara ma ọ bụ ụmị ọkpụkpụ ule.

Onwere ihe egwu di n’ule a?

O nwechaghị ihe egwu dị n’inyocha ọbara. May nwere ike ịnwe obere ihe mgbu ma ọ bụ mmerụ ahụ ebe etinyere agịga ahụ, mana ọtụtụ mgbaàmà na-apụ ngwa ngwa.

Mgbe nyocha ụmị ọkpụkpụ, ị nwere ike ịnwe nkwusi ma ọ bụ ọnya na saịtị ịgba ogwu. Nke a na-apụkarị na ụbọchị ole na ole. Onye na-ahụ maka ahụike gị nwere ike ịkwado ma ọ bụ kwupụta ihe ngbu mgbu iji nyere aka.

Kedu ihe nsonaazụ ahụ pụtara?

Ọ bụrụ na nsonaazụ gị gosiri na ị nwere mkpụrụ ndụ BCR-ABL, yana oke mkpụrụ ndụ ọbara ọcha, enwere ike ịchọpụta na ị nwere ọrịa leukemia myeloid na-adịghị ala ala (CML) ma ọ bụ Ph-positive, nnukwu ọrịa leukemia lymphoblastic (ALL).

Ọ bụrụ na a na-agwọ gị ugbu a maka CML ma ọ bụ Ph-positive ALL, nsonaazụ gị nwere ike igosi:

• Ọnụ ọgụgụ BCR-ABL dị n'ọbara gị ma ọ bụ ụmị ọkpụkpụ na-aba ụba. Nke a nwere ike ịpụta na ọgwụgwọ gị anaghị arụ ọrụ yana / ma ọ bụ na ị na-eguzogide ọgwụ na ụfọdụ ọgwụgwọ.
• Ọnụ ọgụgụ BCR-ABL dị n'ọbara gị ma ọ bụ ụmị ọkpụkpụ na-ebelata. Nke a nwere ike ịpụta na ọgwụgwọ gị na-arụ ọrụ.
• Ọnụ ọgụgụ BCR-ABL dị n'ọbara gị ma ọ bụ ụmị ọkpụkpụ adịghị arị elu ma ọ bụ belata. Nke a nwere ike ịpụta na ọrịa gị kwụsie ike.

Ọ bụrụ na ị nwere ajụjụ gbasara nsonaazụ gị, gwa ndị ọrụ ahụike gị okwu.

Mụtakwuo maka ule nyocha ụlọ, akara ngosi, na nghọta nsonaazụ.

Enwere ihe ọ bụla ọzọ m kwesịrị ịma gbasara nyocha mkpụrụ ndụ ihe nketa BCR-ABL?

Ọgwụgwọ maka ọrịa leukemia myeloid na-adịghị ala ala (CML) na Ph-positive, nnukwu ọrịa leukemia lymphoblastic (ALL) enweela ihe ịga nke ọma na ndị ọrịa nwere ụdị ọrịa kansa ọbara a. Ọ dị mkpa ịhụ onye nlekọta ahụike gị oge niile iji jide n'aka na ọgwụgwọ gị ga-arụ ọrụ. Ọ bụrụ na ị na-eguzogide ọgwụ, onye na-eweta gị nwere ike ịkwado ụdị ọgwụgwọ kansa ndị ọzọ.

Ntughari

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Ejila ozi dị na saịtị a dị ka onye dochie anya nlekọta ahụike ọkachamara ma ọ bụ ndụmọdụ. Kpọtụrụ onye na-ahụ maka ahụike ma ọ bụrụ na ị nwere ajụjụ gbasara ahụike gị.