Antineutrophil Cytoplasmic Antibodies (ANCA) Ule

Ndinaya

• Kedu ihe bụ antineutrophil cytoplasmic antibodies (ANCA) ule?
• Kedu ihe eji ya?
• Kedu ihe kpatara m ji chọọ nyocha ANCA?
• Kedu ihe na - eme n'oge ule ANCA?
• Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?
• Onwere ihe egwu di n’ule a?
• Kedu ihe nsonaazụ ahụ pụtara?
• Onwere ihe ozo ichoro ima banyere ule ANCA?
• Ntughari

Kedu ihe bụ antineutrophil cytoplasmic antibodies (ANCA) ule?

Nnwale a na-achọ ọgwụ nje antineutrophil cytoplasmic (ANCA) n'ime ọbara gị. Antibodies bụ protein nke usoro ahụ ji alụso ọrịa ọgụ na-eme iji lụ ọgụ ihe ndị si mba ọzọ dịka nje na nje. Mana ndị ANCA na-awakpo sel ndị nwere ahụ ike akpọrọ neutrophils (ụdị sel ọbara ọcha) n'amaghị ama. Nke a nwere ike ibute ọgba aghara a maara dị ka autoimmune vasculitis. Autoimmune vasculitis na-akpata mbufụt na ọzịza nke arịa ọbara.

Akụkụ ọbara na - ebu ọbara site na obi gị gaa na akụkụ ahụ gị, anụ ahụ gị na sistemụ ndị ọzọ, ma mechaa laghachite. Pesdị nke arịa ọbara na-agụnye akwara akwara, akwara, na capillaries. Mbufụt na arịa ọbara nwere ike ịkpata nnukwu nsogbu ahụ ike. Nsogbu dị iche iche dabere na arịa ọbara na sistemụ ahụ metụtara.

E nwere ụdị ANCA abụọ dị mkpa. Onye ọ bụla na-elekwasị anya na protein a kapịrị ọnụ n'ime mkpụrụ ndụ ọbara ọcha:

• PANCA, nke na-eleba anya na protein a na-akpọ MPO (myeloperoxidase)
• CANCA, nke na-eleba anya na protein a na-akpọ PR3 (proteinase 3)

Nnwale ahụ nwere ike igosi ma ị nwere otu ụdị mgbochi ma ọ bụ abụọ. Nke a nwere ike inyere onye nlekọta ahụike gị aka ịchọpụta ma gwọọ nsogbu gị.

Aha ndị ọzọ: antibodies ANCA, cANCA pANCA, cytoplasmic neutrophil antibodies, ọbara, anticytoplasmic autoantibodies

Kedu ihe eji ya?

A na-ejikarị ule ANCA achọpụta ma ọ bụrụ na ị nwere ụdị autoimmune vasculitis. E nwere ụdị nsogbu a dị iche iche. Ha niile na-ebute mbufụt na ọzịza nke akwara ọbara, mana ụdị ọ bụla na-emetụta arịa ọbara dị iche iche na akụkụ ahụ. Autodị nke autoimmune vasculitis gụnyere:

• Granulomatosis na polyangiitis (GPA), nke a na-akpọbu ọrịa Wegener. Ọ na-emetụtakarị akpa ume, akụrụ, na mmehie.
• Microscopic polyangiitis (MPA). Nsogbu a nwere ike imetụta ọtụtụ akụkụ ahụ, gụnyere ngụgụ, akụrụ, usoro ụjọ na anụ ahụ.
• Eosinophilic granulomatosis na polyangiitis (EGPA), nke a na-akpọbu ọrịa Churg-Strauss. Ọrịa a na-emetụtakarị akpụkpọ na ngụgụ. Ọ na-ebute ụkwara ume ọkụ mgbe mgbe.
• Polyarteritis nodosa (PAN). Ọrịa a na-emetụtakarị obi, akụrụ, akpụkpọ, na sistem ụjọ nke etiti.

Enwere ike iji nnwale ANCA nyochaa ọgwụgwọ nke nsogbu ndị a.

Kedu ihe kpatara m ji chọọ nyocha ANCA?

Onye na-ahụ maka ahụike gị nwere ike ịnye ule ANCA ma ọ bụrụ na ị nwere mgbaàmà nke autoimmune vasculitis. Mgbaàmà gụnyere:

• Ahụ ọkụ
• Ike ọgwụgwụ
• Iwetulata ibu
• Akwara na / ma ọ bụ nkwonkwo mgbu

Ihe mgbaàmà gị nwekwara ike imetụta otu akụkụ ma ọ bụ karịa kpọmkwem na ahụ gị. Akụ ndị a na-emetụtakarị na mgbaàmà ha na-akpata gụnyere:

• Anya
  • Na-acha ọbara ọbara
  • Ọhụhụ na-adịghị mma
  • Ọnwụ nke ọhụụ
• Ntị
  • Na-agba na ntị (tinnitus)
  • Ntị ntị
• Mmehie
  • Sinus mgbu
  • Imu imi
  • Imi na-agba ọbara
• Akpụkpọ anụ
  • Rashes
  • Mgbu ma ọ bụ ọnya, ụdị ọnyá miri emi nke na-adịghị ala ala na / ma ọ bụ na-alaghachi azụ
• Nsị
  • .Kwara
  • Nsogbu iku ume
  • Obi mgbu
• Akụrụ
  • Ọbara na mmamịrị
  • Mmamịrị ụfụfụ, nke protein na-adị na mmamịrị ahụ na-akpata
• Jọ usoro
  • Ọnụ ọgụgụ na nsị na akụkụ ahụ dị iche iche

Kedu ihe na - eme n'oge ule ANCA?

Onye ọkachamara ahụike ga-ewere ihe nyocha ọbara site na akwara aka gị, jiri obere agịga. Mgbe etinyere agịga ahụ, a ga-achịkọta obere ọbara n'ime ule nyocha ma ọ bụ vial. Nwere ike na-eche ntakịrị ihe mgbe agịga na-abanye ma ọ bụ na-apụta. Nke a na-ewe ihe na-erughị nkeji ise.

Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?

Kwesighi nkwadebe ọ bụla pụrụ iche maka ule ANCA.

Onwere ihe egwu di n’ule a?

O nwechaghị ihe egwu dị n’inyocha ọbara. May nwere ike ịnwe obere ihe mgbu ma ọ bụ mmerụ ahụ ebe etinyere agịga ahụ, mana ọtụtụ mgbaàmà na-apụ ngwa ngwa.

Kedu ihe nsonaazụ ahụ pụtara?

Ọ bụrụ na nsonaazụ gị adịghị mma, ọ pụtara na ihe mgbaàmà gị nwere ike ọ bụghị n'ihi autoimmune vasculitis.

Ọ bụrụ na nsonaazụ gị dị mma, ọ nwere ike ịpụta na ị nwere autoimmune vasculitis. O nwekwara ike igosi ma achọtara cANCA ma ọ bụ pANCAs. Nke a nwere ike inyere aka chọpụta ụdị ụdị vasculitis ị nwere.

N’agbanyeghi ụdị ọgwụ nje ahụrụ, ị nwere ike ịchọ nnwale ọzọ, nke akpọrọ biopsy, iji wee chọpụta nchoputa ahụ. Biopsy bụ usoro nke na-ewepu obere ihe mpempe akwụkwọ ma ọ bụ sel maka ule. Onye na-ahụ maka ahụike gị nwekwara ike ịtụkwuo nyocha iji tụọ ọnụọgụ nke ANCA n'ọbara gị.

Ọ bụrụ na a na-agwọ gị ugbu a maka autoimmune vasculitis, nsonaazụ gị nwere ike igosi ma ọgwụgwọ gị ọ na-arụ ọrụ.

Ọ bụrụ na ị nwere ajụjụ gbasara nsonaazụ gị, gwa ndị ọrụ ahụike gị okwu.

Mụtakwuo maka ule nyocha ụlọ, akara ngosi, na nghọta nsonaazụ.

Onwere ihe ozo ichoro ima banyere ule ANCA?

Ọ bụrụ na nsonaazụ ANCA gị gosipụtara na ị nwere autoimmune vasculitis, enwere ụzọ iji gwọọ ma jikwaa ọnọdụ ahụ. Usoro ọgwụgwọ nwere ike ịgụnye ọgwụ, usoro ọgwụgwọ nke ga-ewepụ ANCA nwa oge na ọbara gị, yana / ma ọ bụ ịwa ahụ.

Ntughari

1. Ahụ ike Allina [Internet]. Minneapolis: Allina Health; C-ANCA mmesho; [akpọrọ 2019 Mee 3]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://account.allinahealth.org/library/content/49/150100
2. Ahụ ike Allina [Internet]. Minneapolis: Allina Health; P-ANCA mmesho; [akpọrọ 2019 Mee 3]; [ihe dị ka ihuenyo 3]. Nweta ya site na: https://account.allinahealth.org/library/content/49/150470
3. Velọ Ọgwụ Cleveland [Internet]. Cleveland (OH): velọ Ọgwụ Cleveland; c2019. Ulkwụ na Footkwụ ọnya; [akpọrọ 2019 Mee 3]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://my.clevelandclinic.org/health/diseases/17169-leg-and-foot-ulcers
4. Nnwale ụlọ nyocha na ntanetị [Intanet]. Washington DC: American Association maka Clinical Chemistry; C2001–2019. Ngwurugwu ANCA / MPO / PR3; [emelitere 2019 Apr 29; zoro aka na 2019 Mee 3]; [ihe dị ka ihuenyo 2]. E Nweta site na: https://labtestsonline.org/tests/ancampopr3-antibodies
5. Nnwale ụlọ nyocha na ntanetị [Intanet]. Washington DC: American Association maka Clinical Chemistry; C2001–2019. Ihe omimi; [emelitere 2017 Jul 10; zoro aka na 2019 Mee 3]; [ihe dị ka ihuenyo 2]. E Nweta site na: https://labtestsonline.org/glossary/biopsy
6. Nnwale ụlọ nyocha na ntanetị [Intanet]. Washington DC: American Association maka Clinical Chemistry; C2001–2019. Vaskulitis; [emelitere 2017 Sep 8; zoro aka na 2019 Mee 3]; [ihe dị ka ihuenyo 2]. E Nweta site na: https://labtestsonline.org/conditions/vasculitis
7. Mansi IA, Opran A, Rosner F. ANCA-Ejikọtara Obere-Vasel Vasculitis. Dọkịta Am Fam [Internet]. 2002 Apr 15 [akpọrọ 2019 Mee 3]; 65 (8): 1615–1621. E Nweta site na: https://www.aafp.org/afp/2002/0415/p1615.html
8. Mayo Clinic Laboratories [Intanet]. Ntọala Mayo maka Mmụta Ahụike na Nnyocha; C1995–2019. Nyocha ID: ANCA: Cytoplasmic Neutrophil Antibodies, Serum: Clinical and Interpretive; [akpọrọ 2019 Mee 3]; [ihe dị ka ihuenyo 4]. E Nweta site na: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/9441
9. National Heart, Lung, na Ọbara Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Nnwale ọbara; [akpọrọ 2019 Mee 3]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.nhlbi.nih.gov/health-topics/blood-tests
10. National Heart, Lung, na Ọbara Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Vaskulitis; [akpọrọ 2019 Mee 3]; [ihe dị ka ihuenyo 2]. O nwere site na: https://www.nhlbi.nih.gov/health-topics/vasculitis
11. Radice A, Sinico RA. Antineutrophil Cytoplasmic Antibodies (ANCA). Nchekwa onwe [Internet]. 2005 Feb [zoro aka na 2019 Mee 3]; 38 (1): 93–103. Odi site na: https://www.ncbi.nlm.nih.gov/pubmed/15804710
12. Ebe UNC Kidney [Internet]. Chapel Hill (NC): Clọ Ọrụ Kidney UNC; c2019. ANCA Ọrịa; [emelitere 2018 Sep; zoro aka na 2019 Mee 3]; [ihe dị ka ihuenyo 3]. O nwere site na: https://unckidneycenter.org/kidneyhealthlibrary/glomerular-disease/anca-vasculitis

Ejila ozi dị na saịtị a dị ka onye dochie anya nlekọta ahụike ọkachamara ma ọ bụ ndụmọdụ. Kpọtụrụ onye na-ahụ maka ahụike ma ọ bụrụ na ị nwere ajụjụ gbasara ahụike gị.