Ọrịa nephritis

Interstitial nephritis bụ ọrịa akụrụ nke oghere ndị dị n'etiti tubili akụrụ na-aza aza. Nke a nwere ike ịkpata nsogbu na etu akụrụ gị si arụ ọrụ.

Interstitial nephritis nwere ike ịbụ nwa oge (nnukwu), ma ọ bụ ọ nwere ike ịdị ogologo oge (ala ala) ma na-akawanye njọ karịa oge.

Dị nnukwu ọrịa nephritis na-ebutekarị bụ nke mmetụta ụfọdụ ọgwụ ụfọdụ na-akpatakarị.

Ihe ndị a nwere ike ibute nephritis interstitial:

• Ọrịa na-arịa ọrịa na-arịa ọrịa (nnukwu nsogbu na-arịa ọrịa nephritis).
• Ọrịa autoimmune, dịka ọrịa okpuru ala antitubular, ọrịa Kawasaki, Sjögren syndrome, systemic lupus erythematosus, ma ọ bụ granulomatosis na polyangiitis.
• Ọrịa.
• Ogologo oge eji ọgwụ dị ka acetaminophen (Tylenol), aspirin, na ọgwụ ndị na-adịghị egbochi ọgwụ ọjọọ (NSAIDs). Nke a na-akpọ analgesic nephropathy.
• Mmetụta nke ụfọdụ ọgwụ nje dị ka penisilini, ampicillin, methicillin, na ọgwụ sulfonamide.
• Mmetụta nke ọgwụ ndị ọzọ dị ka furosemide, thiazide diuretics, omeprazole, triamterene, na allopurinol.
• Obere potassium n’ime ọbara gị.
• Oke calcium ma ọ bụ uric acid dị n’ọbara gị.

Ọrịa nephritis na-ebute ọrịa nwere ike ibute nsogbu akụrụ dị nro ma sie ike, gụnyere oke ọdịda akụrụ. N'ihe dị ka ọkara nke ikpe, ndị mmadụ ga-ebelata oke mmamịrị na akara ndị ọzọ nke nnukwu akụrụ akụrụ.

Mgbaàmà nke ọnọdụ a nwere ike ịgụnye:

• Ọbara na mmamịrị
• Ahụ ọkụ
• Mgbapụ amụba ma ọ bụ belata
• Ọnọdụ uche na-agbanwe (iro ụra, mgbagwoju anya, coma)
• Ọgbụgbọ, vomiting
• Rash
• Ọzịza nke akụkụ ọ bụla nke ahụ
• Ibu ibu (site na idebe mmiri)

Onye nlekọta ahụike ga-eme nyocha anụ ahụ. Nke a nwere ike ikpughe:

• Ọrịa akpa ume ma ọ bụ ụda obi
• Ọbara mgbali elu
• Fluid na ngụgụ (akpa ume)

Nnwale ndị a gụnyere:

• Ọbara ọbara ọbara
• Ọbara ọbara
• BUN na ọkwa okike creatinine
• Ọnwụ ọbara zuru ezu
• Akụrụ biopsy
• Akụrụ ultrasound
• Urinalysis

Ọgwụgwọ dabere n'ihe kpatara nsogbu ahụ. Izere ọgwụ ndị na-eduga n'ọnọdụ a nwere ike ịkwụsị ihe mgbaàmà ngwa ngwa.

Machi nnu na mmiri dị na nri nwere ike melite ọzịza na ọbara mgbali elu. Proteinmachi protein na nri nwere ike inyere aka ịchịkwa mmebi nke ihe mkpofu n’ime ọbara (azotemia), nke nwere ike ibute ihe mgbaàmà nke nnukwu akụrụ akụrụ.

Ọ bụrụ na dialysis dị mkpa, ọ na-achọkarị ya naanị obere oge.

Corticosteroids ma ọ bụ ọgwụ ndị na-egbochi mkpali dị ike karị dị ka cyclophosphamide nwere ike inye aka mgbe ụfọdụ.

Ọtụtụ mgbe, nephritis interstitial bụ nsogbu na-adịru nwa oge. N'ọnọdụ ndị na-adịkarịghị, ọ nwere ike ibute mmebi na-adịgide adịgide, gụnyere ogologo oge (adịghị ala ala) akụrụ akụrụ.

Mmetụta nephritis buru ibu nwere ike ịdị njọ karị ma nwee ike ibute mmebi akụrụ ogologo oge ma ọ bụ na-adịgide adịgide na ndị agadi.

Metabolic acidosis nwere ike ime n'ihi na akụrụ enweghị ike iwepu acid zuru ezu. Nsogbu a nwere ike ibute nnukwu akụrụ akụrụ ma ọ bụ ọrịa akụrụ na-arịa.

Kpọọ onye na-eweta gị ma ọ bụrụ na ị nwere mgbaàmà nke nephritis interstitial.

Ọ bụrụ na ị nwere nephritis interstitial, kpọọ onye na-eweta gị ma ọ bụrụ na ị nwere mgbaàmà ọhụụ, ọkachasị ma ọ bụrụ na ị pere mpe ma ọ bụ nwee mbelata mmamịrị.

Ọtụtụ mgbe, enweghị ike igbochi nsogbu ahụ. Izere ma ọ bụ belata ojiji ị na-a ofụ ọgwụ nke nwere ike ibute ọnọdụ a nwere ike inye aka belata ihe egwu gị. Ọ bụrụ na ọ dị mkpa, onye na-eweta gị ga-agwa gị ọgwụ ndị ị ga-akwụsị ma ọ bụ belata.

Tubulointerstitial nephritis; Ọrịa ogbu na nkwonkwo - interstitial; Nnukwu interstitial (nfụkasị) nephritis

• Akụrụ anatomi

Neilson EG. Tubulointerstitial nephritis. Na: Goldman L, Schafer AI, eds. Ọgwụ Goldman-Cecil. Nke iri abụọ na ise. Philadelphia, PA: Elsevier Saunders; 2016: isi 122.

Perazella MA, Rosner MH. Ọrịa Tubulointerstitial Na: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner na Rector nke akụrụ. Nke iri. Philadelphia, PA: Elsevier; 2020: isi 35.

Tanaka T, Nangaku M. Chronic interstitial nephritis. Na: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Comprehensive Clinical Nephrology. Nke isii. Philadelphia, PA: Elsevier; 2019: isi 62.