Ọrịa Felty

Felty syndrome bụ ọrịa nke gụnyere ọrịa ogbu na nkwonkwo nke na-arịa ogbu na nkwonkwo, mgbịrị aza aza, ọnụ ọgụgụ nke ọbara ọcha na-ebelata, na ibute ọrịa ugboro ugboro. Ọ dị obere.

Amaghị ihe kpatara ọrịa Felty. Ọ na-abụkarị ndị mmadụ na-arịa ọrịa ogbu na nkwonkwo (RA) ogologo oge. Ndị nwere ọrịa a nọ n'ihe egwu ibute ọrịa n'ihi na ha nwere obere sel ọbara dị ọcha.

Mgbaàmà gụnyere:

• Ahụhụ na-erughị ala (malaise)
• Ike ọgwụgwụ
• Adịghị ike na ụkwụ ma ọ bụ ogwe aka
• Loss nke agụụ
• Ọnwụ na-atụghị anya ya
• Ọnya dị na anụahụ
• Ọzịza, nkwesi ike, mgbu na nrụrụ na nkwonkwo
• Ugboro ugboro na-efe efe
• Red anya na-ere ọkụ ma ọ bụ na-agbapụta

Nyocha nke anụ ahụ ga-egosi:

• Ọkpụkpụ aza
• Njikọ ndị na-egosi ihe ịrịba ama nke RA
• O nwere ike imeju imeju na akụkụ lymph

Ọnụọgụ ọbara zuru oke (CBC) nwere ọdịiche ga-egosi obere mkpụrụ ndụ ọbara ọcha akpọrọ neutrophils. Ihe fọrọ nke nta ka ọ bụrụ ndị niile nwere ọrịa Felty nwere ule dị mma maka ihe na-akpata rheumatoid.

Ihe odide afọ ime nwere ike ikwenye na aza aza.

N'ọtụtụ ọnọdụ, ndị nwere ọrịa a anaghị enweta ọgwụgwọ akwadoro maka RA. Ha nwere ike chọọ ọgwụ ndị ọzọ iji gbochie usoro ahụ ji alụso ọrịa ọgụ ma belata ọrụ nke RA.

Methotrexate nwere ike melite obere neutrophil. Ogwu rituximab enweela ihe ịga nke ọma na ndị na-adịghị anabata ọgwụ methotrexate.

Ihe na-akpali akpali nke Granulocyte-colony (G-CSF) nwere ike ibuli ọnụ ọgụgụ ndị na-adịghị mkpa.

Fọdụ ndị mmadụ na-erite uru na mwepụ nke splin (splenectomy).

Enweghị ọgwụgwọ, ọrịa nwere ike ịnọgide na-eme.

RA nwere ike ịka njọ.

Inggwọ RA, Otú ọ dị, kwesịrị ime ka ọrịa Felty dịkwuo mma.

Nwere ike ibute ọrịa na-abịaghachi azụ.

Fọdụ ndị nwere ọrịa Felty amụbawo ọnụ ọgụgụ buru ibu nke mkpụrụ ndụ anwansị granular, a na-akpọkwa LGL leukemia. A ga-eji methotrexate gwọọ ya n'ọtụtụ ọnọdụ.

Kpọọ onye na-ahụ maka ahụike gị ma ọ bụrụ na ị nwee ihe mgbaàmà nke nsogbu a.

Nlekọta ngwa ngwa nke RA na ọgwụ ndị akwadoro ugbu a na-ebelata ihe ize ndụ nke ịmalite ọrịa Felty.

Ọrịa ogbu ogbu na nkwonkwo (RA); Ọrịa Felty

• Ihe mgbochi

Bellistri JP, Muscarella P. Splenectomy maka nsogbu ọrịa hematologic. Na: Cameron JL, Cameron AM, eds. Usoro ọgwụgwọ nke oge a. Agba nke iri na abụọ. Philadelphia, PA: Elsevier; 2017: 603-610.

Erickson AR, Cannella AC, Mikuls TR. Atụmatụ ahụike nke ọrịa ogbu na nkwonkwo. Na: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Akwụkwọ Kelley na Firestein nke Rheumatology. Nke iri. Philadelphia, PA: Elsevier; 2017: isi 70.

Gazitt T, Loughran TP Jr. Chronic neutropenia na LGL leukemia na ọrịa ogbu na nkwonkwo. Hematology Am Soc Hematol Mmụta Mmemme. 2017; 2017 (1): 181-186. PMID: 29222254 www.ncbi.nlm.nih.gov/pubmed/29222254.

Myasoedova E, Turesson C, Matteson EL. Ihe ndi ozo nke oria ogbu na nkwonkwo. Na: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. Nke 7. Philadelphia, PA: Elsevier; 2019: isi nke 95.

Savola P, Brück O, Olson T, et al. Somatic STAT3 mmụba na Ọrịa Ọrịa: ihe gbasara ọrịa na-ahụkarị na nnukwu granular lymphocyte leukemia. Haematologica. 2018; 103 (2): 304-312. PMID: 29217783 www.ncbi.nlm.nih.gov/pubmed/29217783.

Wang CR, Chiu YC, Nwere YC. Nlekọta nke ọma nke neutropenia na-ajụ ike na ọrịa Felty na rituximab. Scand J Rheumatol. 2018; 47 (4): 340-341. PMID: 28753121 www.ncbi.nlm.nih.gov/pubmed/28753121.