Calcium pyrophosphate ogbu na nkwonkwo

Calcium pyrophosphate dihydrate (CPPD) ogbu na nkwonkwo bụ ọrịa nkwonkwo nke nwere ike ibute ọgụ nke ogbu na nkwonkwo. Dị ka gout, kristal na-etolite na nkwonkwo. Ma na ogbu na nkwonkwo a, kristal abụghị ndị sitere na uric acid.

Nkwụnye nke calcium pyrophosphate dihydrate (CPPD) na-ebute ụdị ọrịa ogbu na nkwonkwo a. Mmepụta nke kemịkal a na-eme kristal na cartilage nke nkwonkwo. Nke a na - eduga na mwakpo nke ọzịza nkwonkwo na mgbu na ikpere, nkwojiaka, nkwonkwo ụkwụ, ubu na nkwonkwo ndị ọzọ. N’adịghị ka gout, akwara metatarsal-phalangeal nke mkpịsị ụkwụ ukwu anaghị emetụta.

N'etiti ndị okenye, CPPD bụ ihe na - akpata ọrịa ogbu na nkwonkwo na mberede (nkwonkwo) n'otu nkwonkwo. Ihe kpatara agha ahụ bụ:

• Mmebi nke nkwonkwo
• Hyaluronate ogwu ogbugba na nkwonkwo
• Ọrịa na-arịa ọrịa

Ọrịa ogbu na nkwonkwo CPPD na-emetakarị ndị agadi n'ihi na nkwonkwo nkwonkwo na ọrịa ogbu na nkwonkwo na-abawanye na afọ. Mmebi nkwonkwo dị otú a na-eme ka ọchịchọ nke CPPD dịkwuo njọ. Otú ọ dị, ọrịa ogbu na nkwonkwo CPPD nwere ike mgbe ụfọdụ na-emetụta ndị na-eto eto nwere ọnọdụ dịka:

• Hemochromatosis
• Parathyroid ọrịa
• Ọkpụkpụ akụrụngwa na-adabere na ịrịa ọrịa

N'ọtụtụ ọnọdụ, ọrịa ogbu na nkwonkwo CPPD adịghị akpata mgbaàmà ọ bụla. Kama nke ahụ, ụzarị ọkụ nke nkwonkwo emetụtara dịka ikpere na-egosi njiri mara nke calcium.

Fọdụ ndị nwere nkwụnye ego CPPD na-adịghị ala ala na nnukwu nkwonkwo nwere ike inwe mgbaàmà ndị a:

• Mgbu
• Ọzịza
• Na-ekpo ọkụ
• Na-acha ọbara ọbara

Mmegide nke nkwonkwo mgbu nwere ike ịdịru ọnwa. E nwere ike ọ nweghị ihe mgbaàmà n'etiti ọgụ.

Na ụfọdụ ndị ọrịa ogbu ogbu na nkwonkwo nke CPPD na-ebute oke nkwonkwo na nkwonkwo.

Ọrịa ogbu na nkwonkwo CPPD nwekwara ike ime na spain, ma nke ala ma nke elu. Nrụgide dị na akwara azụ nwere ike ịkpata ihe mgbu na ogwe aka ma ọ bụ ụkwụ.

Ebe ọ bụ na mgbaàmà ahụ yiri nke ahụ, ọrịa ogbu na nkwonkwo CPPD nwere ike inwe mgbagwoju anya na:

• Oru ogbu na nkwonkwo (gout)
• Ọrịa ogbu na nkwonkwo
• Ọrịa ogbu ogbu na nkwonkwo

Ọtụtụ ọnọdụ ogbu na nkwonkwo na-egosi ihe mgbaàmà yiri nke ahụ. Jiri nlezianya na-anwale mmiri njikọta maka kristal nwere ike inyere dọkịta aka ịchọpụta ọnọdụ ahụ.

Nwere ike ịnwale ule ndị a:

• Nnyocha mmiri na-emekọ iji chọpụta mkpụrụ ndụ ọbara ọcha na kristal pyrophosphate calcium
• Ụzarị ọkụ na-ejikọ ọnụ iji chọọ mmebi nkwonkwo na calcium na-etinye na oghere njikọ
• Nlere onyonyo nkwonkwo ndi ozo dika CT scan, MRI ma obu ultrasound
• Nyocha ọbara na-enyocha ọnọdụ ndị ejikọtara na calcium pyrophosphate ogbu na nkwonkwo

Ọgwụgwọ nwere ike ịgụnye iwepu mmiri mmiri iji belata nrụgide na nkwonkwo. A na-etinye agịga n'ime nkwonkwo na mmiri na-achọ. Fọdụ usoro ọgwụgwọ a na-ahụkarị bụ:

• Ntughari nke steroid: iji mesoo nkwonkwo fụrụ akpụ
• Oral steroid: ịgwọ ọtụtụ nkwonkwo fụrụ akpụ
• Ọgwụ ndị na-adịghị egbochi ọgwụ ọjọọ (NSAIDs): iji belata ihe mgbu
• Colchicine: iji mesoo mwakpo nke ogbu na nkwonkwo CPPD
• Maka ọrịa ogbu na nkwonkwo CPPD na ọtụtụ nkwonkwo methotrexate ma ọ bụ hydroxychloroquine nwere ike inye aka

Imirikiti ndị mmadụ na-eme nke ọma na ọgwụgwọ iji belata nnukwu ihe mgbu na nkwonkwo. Otu ọgwụ dị ka colchicine nwere ike inye aka gbochie ọgụ ọzọ. Enweghị ọgwụgwọ iji wepu kristal CPPD.

Ihe nkwonkwo na-adịgide adịgide nwere ike ịme na-enweghị ọgwụgwọ.

Kpọọ onye nlekọta ahụike gị ma ọ bụrụ na ị nwere ọgụ nke nkwonkwo nkwonkwo na nkwonkwo mgbu.

Onweghi uzo amara ama eji egbochi oria a. Otú ọ dị, ịgwọ nsogbu ndị ọzọ nwere ike ịkpata ọrịa ogbu na nkwonkwo CPPD nwere ike ime ka ọnọdụ ahụ ka njọ.

Nleta nleta oge niile nwere ike inye aka igbochi mmebi na-adịgide adịgide nke nkwonkwo emetụtara.

Calcium pyrophosphate dihydrate deposition ọrịa; Ọrịa CPPD; Ọrịa ogbu na nkwonkwo CPPD; Pseudogout; Pyrophosphate ọrịa; Chondrocalcinosis

• Ubu nkwonkwo mbufụt
• Ọrịa ogbu na nkwonkwo
• Ọdịdị nke nkwonkwo

Andrés M, Sivera F, Pascual E. Agwọ maka CPPD: nhọrọ na ihe akaebe. Curr Rheumatol Rep. 2018; 20 (6): 31. PMID: 29675606 pubmed.ncbi.nlm.nih.gov/29675606/.

Edwards NL. Ọrịa Crystal deposition. Na: Goldman L, Schafer AI, eds. Ọgwụ Goldman-Cecil. Nke 26th. Philadelphia, PA: Elsevier; 2020: isi 257.

Terkeltaub R. Calcium crystal ọrịa: calcium pyrophosphate dihydrate na isi calcium phosphate. Na: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Akwụkwọ Kelley na Firestein nke Rheumatology. Nke iri. Philadelphia, PA: Elsevier; 2017: isi nke 96.