Sclerosing cholangitis

Sclerosing cholangitis na-ezo aka na ọzịza (mbufụt), ụkọ, na mbibi nke eriri mmiri n'ime na n'èzí imeju.

Ihe kpatara ọnọdụ a amaghị n'ọtụtụ ọnọdụ.

Enwere ike ịhụ ọrịa ahụ na ndị nwere:

• Ọrịa bowel inflammatory (IBD) dịka ọnya afọ na ọrịa Crohn
  
• Nsogbu autoimmune
• -Adịghị ala ala pancreatitis (inflamed pancreas)
• Sarcoidosis (ọrịa nke na-akpata mbufụt n'akụkụ dị iche iche nke ahụ)

Mkpụrụ ndụ ihe nketa nwekwara ike ịbụ ihe kpatara ya. Sclerosing cholangitis na-emekarị na ụmụ nwoke karịa ụmụ nwanyị. Ọrịa a dị obere na ụmụaka.

Nwekwara ike kpatara sclerosing cholangitis:

• Choledocholithiasis (gallstones na bile duct)
• Ọrịa na imeju, gallbladder, na bile ducts

Ihe mgbaàmà mbụ na-abụkarị:

• Ike ọgwụgwụ
• Itching
• Yellowing nke anụ ahụ na anya (jaundice)

Otú ọ dị, ụfọdụ ndị enweghị ihe mgbaàmà.

Mgbaàmà ndị ọzọ nwere ike ịgụnye:

• Imeju imeju
• Na-abawanye
• Enweghi agụụ na ọnwụ
• Tinyegharịa ngosipụta nke cholangitis

Ọ bụ ezie na ụfọdụ ndị enweghị mgbaàmà, nyocha ọbara na-egosi na ha nwere ọrụ imeju na-adịghị mma. Onye nlekọta ahụike gị ga-achọ:

• Ọrịa ndị na-ebute ụdị nsogbu ahụ
• Ọrịa ndị na - emekarị na ọnọdụ a (ọkachasị IBD)
• Nkume okwute

Ule nke na-egosi cholangitis gụnyere:

• Ime CT i scanomi
• Ime ultrasound
• Endoscopic retrograde cholangiopancreatography (ERCP) Ọgwụgwụ
• Ọkpụkpụ imeju
• Magnetik resonance cholangiopancreatography (MRCP)
• Percutaneous transhepatic cholangiogram (PTC) Nnukwu

Nnyocha ọbara na-agụnye enzymes imeju (imeju ọrụ ume).

Ọgwụ ndị enwere ike iji gụnyere:

• Cholestyramine (dika Prevalite) iji mesoo itching
• Ursodeoxycholic acid (ursodiol) iji meziwanye ọrụ imeju
• Fat-soluble vitamin (D, E, A, K) iji dochie ihe furu efu site n'ọrịa n'onwe ya
• Ọgwụ nje iji gwọọ ọrịa n'ime eriri afọ bile

Enwere ike ime usoro ịwa ahụ ndị a:

• Tinye ogologo tube dị warara nke nwere balloon na njedebe iji meghee warara (njedebe endoscopic balloon nke nlezianya)
• Ntinye nke drain ma ọ bụ ọkpọkọ maka warara dị oke (nhịahụ) nke bile ducts
• Proctocolectomy (mwepụ nke eriri afọ na ikensi, maka ndị nwere ọnya afọ na sclerosing cholangitis) anaghị emetụta ọganihu nke isi sclerosing cholangitis (PSC)
• Imeju umeji

Otú ndị mmadụ si eme nke ọma dịgasị iche iche. Ọrịa ahụ na-akawanye njọ karịa oge. Mgbe ụfọdụ ndị mmadụ na-etolite:

• Ascites (buildup nke mmiri dị n'etiti oghere nke afọ na akụkụ afọ) na varices (abawanye veins)
• Biliary cirrhosis (mbufụt nke bile ducts)
• Ọkpụkpụ imeju
• Jaundice na-adịgide adịgide

Fọdụ ndị mmadụ na-ebute ọrịa ịrịa mmiri mmiri nke na-alaghachi azụ.

Ndị mmadụ nwere ọnọdụ a nwere nnukwu ihe ọghọm nke ịrịa ọrịa kansa nke eriri afọ (cholangiocarcinoma). Ekwesịrị inyocha ha oge niile site na nyocha imepụta imeju na nyocha ọbara. Ndị mmadụ nwekwara IBD nwere ike ịnwe ohere dị ukwuu nke ịrịa ọrịa kansa nke eriri afọ ma ọ bụ ikensi ma nwee kwa afọ colonoscopy.

Nsogbu nwere ike ịgụnye:

• Ọkpụkpụ esophageal na-agba ọbara
• Ọrịa cancer na ọrịa bile (cholangiocarcinoma)
• Cirrhosis na imeju imeju
• Ofufe Ọrịa nke biliary usoro (cholangitis)
• Mkpokọta nke mmiri bile
• Ọrịa vitamin

Isi sclerosing cholangitis; PSC

• Usoro nri
• Okporo ụzọ

Bowlus C, Assis DN, Goldberg D. Isi na sclerosing cholangitis. Na: Sanyal AJ, Boyer TD, Lindor KD, Terrault NA, eds. Ọrịa Zakim na Boyer. Nke 7. Philadelphia, PA: Elsevier; 2018: isi 43.

Ross AS, Kowdley KV. Isi sclerosing cholangitis na nlọghachi pyogenic cholangitis. Na: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger na Ọrịa Cancer nke Fordtran na Ọrịa Imeju: Pathophysiology / Diagnosis / Management. Nke iri. Philadelphia, PA: Elsevier Saunders; 2016: isi nke 68.

Zyromski NJ, Pitt HA. Njikwa nke sclerosing cholangitis isi. Na: Cameron JL, Cameron AM, eds. Usoro ọgwụgwọ nke oge a. Agba nke iri na abụọ. Philadelphia, PA: Elsevier; 2017: 453-458.