HER2 (Ọrịa ara ara) Ule

Ndinaya

• Kedu ihe bụ HER2 ọrịa cancer ara?
• Kedu ihe eji ya?
• Kedu ihe kpatara m ji chọọ HER2 ara ure ara?
• Kedu ihe na - eme n'oge ule ọrịa ara HER2?
• Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?
• Onwere ihe egwu di n’ule a?
• Kedu ihe nsonaazụ ahụ pụtara?
• Onwere ihe ozo m choro ima banyere HER2 cancer cancer ara?
• Ntughari

Kedu ihe bụ HER2 ọrịa cancer ara?

HER2 na-anọchi anya ihe na - akpata nnabata epidermal nke mmadụ na - anabata ihe. Ọ na-etinye aka na uto mkpụrụ ndụ nkịtị.

Mkpụrụ ndụ ihe nketa bụ ihe nketa dị mkpa sitere n'aka nne gị na nna gị. N'ime ụfọdụ ọrịa cancer, ọkachasị kansa ara, mkpụrụ ndụ HER2 na-agbanwe (agbanwe) ma na-emepụtakwu mkpụrụ ndụ. Mgbe nke a mere, mkpụrụ ndụ HER2 na - emepụta protein HER2 nke ukwuu, na - eme ka mkpụrụ ndụ kee ma too ngwa ngwa.

Cancers nwere ogo HER2 protein dị ka HER2-nti. A na-akpọ kansa ndị nwere obere protein dị ka HER2-adịghị mma. Ihe dị ka pasent 20 nke ọrịa ara ure bụ HER2.

Nyocha HER2 na-elele ihe atụ nke anụ ahụ akpụ. Zọ ndị a na-ahụkarị iji nwalee anụ ahụ akpụ bụ:

• Immunohistochemistry (IHC) ule na-atụle protein HER2 n'elu sel
• Fluorescence in situationization (FISH) ule na-achọ ụma ọzọ nke mkpụrụ ndụ HER2

Typesdị ule abụọ a nwere ike ịkọ ma ị nwere ọrịa kansa HER2. Ọgwụ ndị lekwasịrị anya n'ọrịa ara ure HER2 nwere ezigbo ọfụma.

Aha ndị ọzọ: mmụba epidermal na-akpata ihe nnabata 2, ERBB2 amplification, HER2 oke ngosi, HER2 / neu tests

Kedu ihe eji ya?

A na-ejikarị HER2 enyocha iji chọpụta ma ọrịa kansa ọ̀ bụ HER2. A na-ejikwa ya mgbe ụfọdụ iji hụ ma ọ bụrụ na ọrịa kansa na-aza ọgwụgwọ ma ọ bụ na ọrịa kansa alọghachila mgbe a gwọchara ya.

Kedu ihe kpatara m ji chọọ HER2 ara ure ara?

Ọ bụrụ na achọpụtala na ị nwere ọrịa ara ara, ị nwere ike ịchọ ule a iji chọpụta ma ọ bụrụ na kansa gị bụ HER2-positive ma ọ bụ HER2-adịghị mma. Ọ bụrụ na a na-agwọ gị maka ọrịa HER2 nwere ọrịa ara ara, ịnwere ike ịnwale ule a:

• Chọpụta ma ọgwụgwọ gị ọ na-arụ ọrụ. Usoro nkịtị nke HER2 nwere ike ịpụta na ị na-anabata ọgwụgwọ. Ọkwa dị elu nwere ike ịpụta na ọgwụgwọ anaghị arụ ọrụ.
• Chọpụta ma ọ bụrụ na ọrịa kansa alọghachila n’ọgwụgwọ.

Kedu ihe na - eme n'oge ule ọrịa ara HER2?

Imirikiti ule HER2 gụnyere ịnata ihe atụ nke anụ ahụ akpụ na usoro a na-akpọ biopsy. E nwere ụzọ usoro biopsy atọ dị mkpa:

• Ezi agịga agụụ biopsy, nke na-eji agịga dị ezigbo mkpa wepụ sel nke ara ma ọ bụ mmiri mmiri
• Isi agị biopsy, nke na-eji agịga buru ibu wepụ ihe nlele
• Psywa ahụ biopsy, nke na-ewepu ihe nlele na obere, usoro ọgwụgwọ

Ezigbo agịga agụụ na isi agịga biopsies na-agụnye usoro ndị a:

• Ga-edina n'akụkụ ma ọ bụ ịnọdụ ala na tebụl nyocha.
• Onye nlekọta ahụike ga-ehichapụ saịtị biopsy ma gbanye ya na ọgwụ anestetiiki ka ị ghara inwe ihe mgbu n'oge usoro ahụ.
• Ozugbo akuku ahu ghasara, onye na - enye ya ga - etinye ogwu ogwu na acho ya ma obu ihe ogwu biopsy n’ime saiti biopsy ma wepu ihe nlere nke aru ma obu mmiri.
• I nwere ike inwe ntakịrị nrụgide mgbe ewepụrụ ihe nlele ahụ.
• A ga-etinye nrụgide na saịtị biopsy ruo mgbe ọbara ọgbụgba ahụ kwụsịrị.
• Onye na-eweta gị ga-etinye bandeeji na-adịghị ọcha na saịtị biopsy.

Na ịwa ahụ biopsy, dọkịta na-awa ahụ ga-eme obere mbepụ gị na akpụkpọ iji wepụ ihe niile ma ọ bụ akụkụ nke ara ara. A na-eme ọgwụ biopsy ịwa ahụ mgbe ụfọdụ ma ọ bụrụ na a gaghị enwe ike iji akpụ mkpụrụ ndụ nweta agịga biopsy. Urgicalwa ahụ biopsies na-agụnyekarị usoro ndị a.

• Ga-edina na tebụl na-arụ ọrụ. Enwere ike itinye IV (intravenous line) na ogwe aka gị ma ọ bụ aka gị.
• Enwere ike inye gị ọgwụ, nke akpọrọ ọgwụ na-akụjụ ahụ, iji nyere gị aka izu ike.
• A ga-enye gị ọgwụ mgbochi mpaghara ma ọ bụ izugbe ka ị ghara inwe ihe mgbu n'oge usoro ahụ.
  • Maka ọgwụ mgbochi ọrịa, onye na-ahụ maka ahụike ga-agbanye ọgwụ biopsy site na ọgwụ iji belata mpaghara ahụ.
  • Maka anesthesia izugbe, ọkachamara a na-akpọ anesthesiologist ga-enye gị ọgwụ ka ị wee daa mgbe usoro ahụ.
• Ozugbo mpaghara biopsy gwụrụ ma ọ bụ na ị amaghị ihe ọ bụla, dọkịta na-awa ahụ ga-eme obere ara n'ime ara ya wee wepu akụkụ ma ọ bụ ihe niile. A pụkwara iwepụ ụfọdụ anụ ahụ dị gburugburu akụkụ ahụ.
• Iberibe akpụkpọ ahụ gị ga-eji stitches ma ọ bụ eriri nrapado.

Ofdị biopsy ị nwere ga-adabere n'ihe dị iche iche, gụnyere nha na ebe etuto ahụ dị. Enwere ike tụọ HER2 na nyocha ọbara, mana nyocha ọbara maka HER2 egosipụtaghị na ọ bara uru maka ọtụtụ ndị ọrịa. Yabụ na anaghị atụkarị aro ya.

Mgbe ewerechara ihe anụ ahụ gị, a ga-anwale ya n'otu ụzọ abụọ:

• A ga-atụle ọkwa protein HER2.
• A ga-elele nlele ahụ maka mkpụrụ akwụkwọ ndị ọzọ nke mkpụrụ ndụ HER2.

Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?

Won’t gaghị achọ nkwadebe pụrụ iche ma ọ bụrụ na ị na-enweta ọgwụ mgbochi mpaghara (nkwụsị nke saịtị biopsy). Ọ bụrụ n ’ịestụ ọgwụ nwuru anwu n’ozuzu, ị nwere ike ibu ọnụ (agaghị eri ma ọ bụ drinkụọ ihe ọ )ụ )ụ) ruo ọtụtụ awa tupu ịwa ahụ. Dọkịta dọkịta gị ga-enye gị ntụziaka ndị a kapịrị ọnụ karị. Ọzọkwa, ọ bụrụ na ị na-enweta ọgwụ mgbochi ma ọ bụ ọgwụ mgbochi izugbe, jide n'aka na ị na-ahazi onye ga-ebuga gị n'ụlọ. Nwere ike ịbụ groggy na mgbagwoju anya mgbe ị na-eteta si usoro.

Onwere ihe egwu di n’ule a?

May nwere ike ịnwe ntakịrị ọnya ma ọ bụ ọbara ọgbụgba na saịtị nke biopsy. Mgbe ụfọdụ saịtị ahụ na-ebute ọrịa. Ọ bụrụ na nke ahụ emee, a ga-eji ọgwụ nje na-agwọ gị. Byopsy ịwa ahụ nwere ike ịkpata ụfọdụ mgbu na ahụ erughị ala. Onye na-ahụ maka ahụike gị nwere ike ịkwado ma ọ bụ dee ọgwụ ga-enyere gị aka ịka mma.

O nwechaghị ihe egwu dị n’inyocha ọbara. May nwere ike ịnwe obere ihe mgbu ma ọ bụ mmerụ ahụ ebe etinyere agịga ahụ, mana ọtụtụ mgbaàmà na-apụ ngwa ngwa.

Kedu ihe nsonaazụ ahụ pụtara?

Ọ bụrụ na achọtara protein HER2 dị elu karịa ka ọ dị na mbụ ma ọ bụ karịa nke mkpụrụ ndụ HER2, ọ nwere ike bụrụ na ị nwere ọrịa kansa HER2. Ọ bụrụ na nsonaazụ gị gosipụtara oke protein HER2 ma ọ bụ mkpụrụ ndụ ihe nketa HER2 nkịtị, ị nwere ike ịnwe ọrịa kansa HER2.

Ọ bụrụ na nsonaazụ gị adịghị mma ma ọ bụ na-adịghị mma, enwere ike ịmegharị gị ọzọ, ma ọ bụ jiri ụdị akpụ dị iche ma ọ bụ jiri usoro nyocha dị iche. Ọtụtụ mgbe, IHC (nyocha maka protein HER2) na-ebu ụzọ, na-esote FISH (nyocha maka mkpụrụ akwụkwọ ndị ọzọ). Nyocha IHC dị ọnụ ala ma na-enye nsonaazụ ngwa ngwa karịa FISH. Mana imirikiti ndị ọkachamara banyere ara na-eche na ule azụ bụ nke ziri ezi.

Ọgwụgwọ maka ọrịa ara ure HER2 nwere ike ịrịa ọrịa cancer, yana mmetụta dị ole na ole. Usoro ọgwụgwọ ndị a adịghị arụ ọrụ na ọrịa cancer HER2.

Ọ bụrụ na a na-agwọ gị maka ọrịa kansa HER2, nsonaazụ nkịtị nwere ike ịpụta na ị na-aza ọgwụgwọ. Nsonaazụ gosiri na ọnụọgụ dị elu karịa nke nkịtị nwere ike ịpụta na ọgwụgwọ gị anaghị arụ ọrụ, ma ọ bụ na ọrịa kansa alọghachila n'ọgwụgwọ.

Mụtakwuo maka ule nyocha ụlọ, akara ngosi, na nghọta nsonaazụ.

Onwere ihe ozo m choro ima banyere HER2 cancer cancer ara?

Ọ bụ ezie na ọ bụ ihe a na-ahụkarị na ụmụ nwanyị, ọrịa kansa, gụnyere HER2 nwere ọrịa ara ure, nwekwara ike imetụta ụmụ nwoke. Ọ bụrụ na a chọpụtala na mmadụ nwere ọrịa kansa, enwere ike ịkwado HER2 ule.

Na mgbakwunye, ụmụ nwoke na ụmụ nwanyị nwere ike ịchọ nyocha HER2 ma ọ bụrụ na achọpụtala ha ụfọdụ ọrịa kansa nke afọ na esophagus. Ọrịa cancer ndị a mgbe ụfọdụ nwere ogo dị elu nke protein HER2 ma nwee ike ịzaghachi nke ọma ọgwụgwọ ọgwụgwọ HER2.

Ntughari

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Ejila ozi dị na saịtị a dị ka onye dochie anya nlekọta ahụike ọkachamara ma ọ bụ ndụmọdụ. Kpọtụrụ onye na-ahụ maka ahụike ma ọ bụrụ na ị nwere ajụjụ gbasara ahụike gị.