10 Uru Mkpụrụ Mkpụrụ Mkpụrụ vaịn, Dabere na Sayensị

Ndinaya

• 1. Nwere ike belata ọbara mgbali
• 2. Nwere ike imeziwanye ọbara
• 3. Nwere ike belata mmebi oxidative
• 4. Nwere ike melite ogo collagen na ike ọkpụkpụ
• 5. Na-akwado ụbụrụ gị ka ọ na-aka nka
• 6. Nwere ike melite ọrụ akụrụ
• 7. Nwere ike igbochi ọrịa na-efe efe
• 8. Nwere ike belata ọrịa cancer
• 9. Nwere ike ichebe umeji gị
• 10. Na-eme ka ọnya ọnya na ọdịdị pụta
• Omume puru omume
• Isi okwu

Mkpụrụ vaịn na-ewepụta (GSE) bụ mmeju ihe oriri na-edozi site na iwepu, ihicha, na ime ka mkpụrụ vaịn na-atọ ụtọ.

Mkpụrụ vaịn bara ọgaranya na antioxidants, gụnyere phenolic acids, anthocyanins, flavonoids, na oligomeric proanthocyanidin complexes (OPCs).

N'ezie, GSE bụ otu n'ime isi mmalite ama ama nke proanthocyanidins (,).

N'ihi ọdịnaya ya na-egbochi antioxidant, GSE nwere ike inye aka gbochie ọrịa ma chebe onwe ya pụọ ​​na nrụgide oxidative, mmebi anụ ahụ, na mbufụt ().

Rịba ama na mkpụrụ osisi mkpụrụ vaịn na mkpụrụ osisi mkpụrụ vaịn na-ere ahịa dị ka mgbakwunye na mkpirisi site na acronym GSE. Isiokwu a tụlere wepụ mkpụrụ vaịn.

Nke a bụ uru iri nke mkpụrụ vaịn na-enweta na ahụike, ihe niile dabere na sayensị.

1. Nwere ike belata ọbara mgbali

Ọtụtụ ọmụmụ achọpụtawo mmetụta nke GSE na ọbara mgbali elu.

Nyochaa nke ọmụmụ 16 na mmadụ 810 nwere ọbara mgbali elu ma ọ bụ ihe egwu dị elu nke ya chọpụtara na ị takingụ 100-2,000 mg nke GSE kwa ụbọchị belata mgbatị ọbara systolic na diastolic (ọnụ ọgụgụ dị elu na ala) site na nkezi nke 6.08 mmHg na 2.8 mmHg, karị.

Ndị nọ n'okpuru afọ 50 na oke ibu ma ọ bụ nsogbu metabolic gosipụtara mmụba kasịnụ.

Nsonaazụ kachasị mma sitere na obere ọgwụ nke 100-800 mg kwa ụbọchị maka izu 8-16, karịa otu mkpụrụ ọgwụ 800 mg ma ọ bụ karịa ().

Nnyocha ọzọ mere na ndị okenye 29 nwere ọbara mgbali elu chọpụtara na ị takingụ 300 mg nke GSE kwa ụbọchị wedara ọbara mgbali elu site na 5.6% na ọbara mgbali diastolic site na 4.7% mgbe izu isii gasịrị ().

Na nchikota GSE nwere ike inye aka belata ọbara mgbali, ọkachasị ndị na-eto eto ruo n'etiti ndị toro eto na ndị buru oke ibu.

2. Nwere ike imeziwanye ọbara

Studiesfọdụ ọmụmụ na-egosi na GSE nwere ike imeziwanye ọbara.

N'ime ihe ọmụmụ 8-izu na ụmụ nwanyị 17 dị mma postmenopausal, na-ewere 400 mg nke GSE nwere mmetụta dị nro nke ọbara, nwere ike belata ihe ize ndụ nke mkpụkọ ọbara ().

Ọmụmụ ihe ọzọ na ụmụ agbọghọ 8 nwere ahụike tụlere mmetụta nke otu ọgwụ 400-mg nke proanthocyanidin sitere na GSE ozugbo nke awa 6 nọdụrụ. E gosipụtara iji belata ọzịza ụkwụ na edema site na 70%, ma e jiri ya tụnyere ị takingụghị GSE.

N'otu ọmụmụ ihe ahụ, ụmụ agbọghọ 8 ndị ọzọ nwere ahụike bụ ndị were 133-mg kwa ụbọchị nke proanthocyanidins site na GSE maka ụbọchị 14 nwetara 40% obere ụkwụ ụkwụ mgbe awa 6 nọ ọdụ ().

Na nchikota E gosipụtara GSE iji meziwanye ọbara na belata ihe ize ndụ nke ịkpụkọta ọbara, nke nwere ike ịbara ndị nwere nsogbu ọbara.

3. Nwere ike belata mmebi oxidative

Ọbara dị elu nke LDL (ọjọọ) cholesterol bụ ihe amaara ama na-akpata ọrịa obi.

Ọxịdashọn nke LDL cholesterol na-abawanye ihe egwu a ma na-arụ ọrụ dị mkpa na atherosclerosis, ma ọ bụ na-eme ka ihe ncheta dị na akwara gị ().

Achọpụtawo ihe mgbakwunye GSE iji belata LDL oxidation nke nri abụba dị elu na-ebute n'ọtụtụ ọmụmụ ụmụ anụmanụ (,,).

Fọdụ nnyocha ụmụ mmadụ mere gosiri ihe yiri ya (,).

Mgbe mmadụ 8 dị mma riri nri dị oke abụba, na-ewere 300 mg nke GSE gbochie oxidation nke abụba n'ime ọbara, ma e jiri ya tụnyere mmụba 150% hụrụ na ndị na-ewereghị GSE ().

N'ọmụmụ ihe ọzọ, ndị okenye 61 siri ike hụrụ 13.9% Mbelata LDL oxidized mgbe ha nụsịrị 400 mg nke GSE. Otú ọ dị, nchọpụta yiri nke ahụ enweghị ike ịmeghachi nsonaazụ ndị a (,).

Ọzọkwa, otu ọmụmụ na mmadụ 87 na-awa ahụ obi chọpụtara na ị na-ewere 400 mg nke GSE ụbọchị tupu ịwa ahụ belata nrụgide oxidative. Ya mere, GSE nwere ike ichebe megide mmebi obi ọzọ ().

Na nchikota GSE nwere ike inye aka belata ihe ize ndụ gị nke ịrịa ọrịa obi site na igbochi oxidation nke LDL (ọjọọ) cholesterol ma belata ọxịdashọn na anụ ahụ obi n'oge oge nrụgide.

4. Nwere ike melite ogo collagen na ike ọkpụkpụ

Flaba ụba oriri flavonoid nwere ike imezi njikọ collagen na ọkpụkpụ ọkpụkpụ.

Dika ezigbo flavonoids, GSE nwere ike inye aka mee ka okpukpu gi na ike gi di ike.

N'ezie, ọmụmụ ụmụ anụmanụ achọpụtala na ịgbakwunye GSE ma ọ bụ obere calcium, ọkọlọtọ, ma ọ bụ nnukwu calcium nri nwere ike ime ka ọkpụkpụ ọkpụkpụ, ọdịnaya ịnweta, na ike ọkpụkpụ (,).

Ọrịa ogbu ogbu na nkwonkwo bụ ọnọdụ autoimmune nke na-ebute oke nsị na mbibi nke ọkpụkpụ na nkwonkwo.

Nnyocha nke anụmanụ egosiwo na GSE nwere ike igbochi mbibi ọkpụkpụ na ọrịa ogbu na nkwonkwo autoimmune (,,).

GSE belatakwara ihe mgbu, ọkpụkpụ na-emebi ihe, na nkwonkwo nkwonkwo na ụmụ oke osteoarthritic, na-emezi ọkwa nke collagen ma na-ebelata cartilage ọnwụ ().

N’agbanyeghi ihe nchoputa di nma si na nyocha umu anumanu, omumu mmadu adighi.

Na nchikota Nnyocha nke anụmanụ na-egosi nsonaazụ na-ekwe nkwa banyere ikike GSE iji nyere aka ịgwọ ọnọdụ ogbu na nkwonkwo ma kwalite ahụike collagen. Agbanyeghị, nyocha sitere na mmadụ adịghị.

5. Na-akwado ụbụrụ gị ka ọ na-aka nka

A na-eche Flavonoids ’nke antioxidant na mgbochi mkpali na-egbu oge ma ọ bụ belata mmalite nke ọrịa neurodegenerative dị ka ọrịa Alzheimer ().

Otu n'ime ihe ndị mejupụtara GSE bụ gallic acid, nke anụmanụ na ụlọ nyocha gosipụtara na ọ nwere ike igbochi nhazi nke fibrils site na beta-amyloid peptides ().

Yọkọ protein-beta-amyloid dị n'ụbụrụ bụ njirimara nke ọrịa Alzheimer ().

Nnyocha nke anụmanụ achọpụtawo na GSE nwere ike igbochi ncheta ncheta, meziwanye ọnọdụ uche na ụbụrụ antioxidant, ma belata ọnya ụbụrụ na ụyọkọ amyloid (,,,).

Otu ihe ọmụmụ 12-izu na 111 ndị toro eto nwere ahụike chọpụtara na ịnara 150 mg nke GSE kwa ụbọchị ka mma, asụsụ, na ncheta oge na-adịghị anya ().

Agbanyeghị, ọmụmụ mmadụ banyere iji GSE na ndị okenye nwere ncheta na-enweghị atụ ma ọ bụ ụkọ ihe ọmụma adịghị.

Na nchikota GSE na-egosi ikike igbochi ọtụtụ njirimara mbibi nke ụbụrụ na ntụgharị uche. Agbanyeghị, ọ dị mkpa ịmụtakwu ihe gbasara mmadụ.

6. Nwere ike melite ọrụ akụrụ

Akụrụ gị na-adịkarị mfe mmebi nke oxyidative, nke na-enweghị ike ịgbanwe agbanwe.

Nnyocha nke anụmanụ egosiwo na GSE nwere ike belata mmebi akụrụ ma melite ọrụ site na mbenata nrụgide oxidative na mmebi mkpali (,,).

N'ime otu nnyocha, e nyere mmadụ iri abụọ na atọ na-arịa ọrịa akụrụ na-adịghị ala ala nyere gram 2 nke GSE kwa ụbọchị maka ọnwa 6 wee jiri ya tụnyere otu placebo. Urinary protein belatara site na 3% yana akụrụ filtration mma site 9%.

Nke a pụtara na akụrụ ndị nọ n'ule ahụ nwere ike ịmị mamịrị karịa akụrụ nke ndị nọ na otu placebo ().

Na nchikota GSE nwere ike inye nchebe megide mmebi site na nrụgide oxidative na mbufụt, si otú a na-akwalite ahụike akụrụ.

7. Nwere ike igbochi ọrịa na-efe efe

GSE gosipụtara ihe na-ekwe nkwa antibacterial na antifungal.

Nnyocha egosiwo na GSE na-egbochi uto nke nje bacteria na-ebutekarị, gụnyere Campylobacter na E. coli, ha abụọ na-abụkarị maka nsị nri siri ike na iwe iwe (33, 34).

Na nyocha ụlọ nyocha, a hụrụ GSE iji gbochie nsogbu 43 nke ọgwụ mgbochi Staphylococcus aureus nje ().

Candida bụ ihe na-eko achịcha na-eko yist nke nwere ike ibute ọrịa candida oge ụfọdụ, ma ọ bụ ụfụ. A na-eji GSE eme ihe n’ọgwụ ọdịnala dị ka ihe eji agwọ candida.

N'ime otu ọmụmụ, a na-enye ụmụ oke nwere candidiasis na-ahụ maka ọgwụ GSE ihe ọ bụla ụbọchị abụọ ọ bụla maka ụbọchị 8. E gbochiri ọrịa ahụ mgbe ụbọchị 5 gachara wee laa mgbe 8 () gasịrị.

O bu ihe nwute, omumu mmadu banyere ikike GSE iji nyere aka gwo oria ndi oria ka enweghi.

Na nchikota GSE nwere ike igbochi ọtụtụ microbes ma nye nchebe pụọ na nje nje na-eguzogide ọgwụ nje, ọrịa nje na-ebute nri, na ọrịa fungal dị ka candida.

8. Nwere ike belata ọrịa cancer

Ihe kpatara ọrịa kansa dị mgbagwoju anya, ọ bụ ezie na mmebi DNA bụ ihe bụ isi.

Nnukwu nri nke antioxidants, dị ka flavonoids na proanthocyanidins, jikọtara ya na mbelata nke ọrịa cancer dị iche iche ().

Ọrụ antioxidant nke GSE egosiputa ikike igbochi ara mmadụ, ngụgụ, afọ, mkpụrụ ndụ squamous ọnụ, imeju, prostate, na usoro pancreatic cell na lab lab (,,,).

Na ihe omumu nke anụmanụ, egosiputara GSE iji mee ka ihe di iche iche nke chemotherapy di iche (,,).

GSE yiri ka ọ na-echebe megide nrụgide oxidative na nsị nke imeju ka ị na-eche ihe omume chemotherapy na mkpụrụ ndụ cancer (,,).

Ntụleghachi nke ọmụmụ ụmụ anụmanụ 41 chọpụtara na ma GSE ma ọ bụ proanthocyanidins belatara nsị na-akpata ọrịa cancer na mmebi n'ime ihe niile mana otu n'ime ọmụmụ ihe ().

Buru n'uche na anticancer na chemopreventive nwere nke GSE na proanthocyanidins nwere ike ọ gaghịzi enyefe ndị nwere ọrịa kansa. Ọ dị mkpa ịmụtakwu ihe banyere ụmụ mmadụ.

Na nchikota Na nyocha ụlọ nyocha, egosiputara GSE iji gbochie kansa n'ime ụdị sel dị iche iche nke mmadụ. GSE pụtakwara na ọ na-ebelata ọgwụ na-emetụta ọgwụ na ọmụmụ anụmanụ na-enweghị mmetụta na-adịghị mma. Ọ dị mkpa iji nyocha mmadụ dabere na mmadụ.

9. Nwere ike ichebe umeji gị

Imeju gị na-arụ ọrụ dị mkpa n’ime ka ị belata ihe na-emerụ ahụ nke e webatara na ahụ gị site na ọgwụ ọjọọ, ọrịa nje, mmetọ, mmanya na ihe ndị ọzọ.

GSE yiri ka ọ nwere mmetụta nchekwa na imeju gị.

Na nyocha nyocha-tube, GSE belatara mbufụt, a na-emegharị antioxidants, ma chebe ya pụọ ​​na mmebi na-enweghị nnwere onwe n'oge nsị na-egbu egbu (,,).

Imeju enzyme alanine aminotransferase (ALT) bụ isi ihe na-egosi nsị nsị, nke pụtara na ọkwa ya na-arị elu mgbe imeju ahụ akwagidela mmebi ().

N'otu nnyocha, e nyere ndị mmadụ 15 nwere ọrịa imeju na-egbu egbu na-egbu egbu na ọkwa dị elu ALT na GSE maka ọnwa 3. A na-enyocha enzymes imeju kwa ọnwa, ma jiri ya tụnyere ị withụ 2 gram nke vitamin C kwa ụbọchị.

Mgbe ọnwa 3 gasịrị, otu GSE nwetara 46% Mbelata ALT, ebe vitamin C gosipụtara obere mgbanwe ().

Na nchikota GSE pụtara ichebe umeji gị megide nsị na mmebi nke ọgwụ na-akpata. Agbanyeghị, ọ dị mkpa ịmụtakwu ihe gbasara mmadụ.

10. Na-eme ka ọnya ọnya na ọdịdị pụta

Ọtụtụ ọmụmụ anụmanụ achọpụtala GSE nwere ike inyere aka ọnya ọnya (,, 52).

Ihe omumu mmadu gosiputara nkwa.

N'ime otu ọmụmụ ihe dị otú a, enyere ndị okenye iri atọ na ise gbasiri ike bụ ndị mere obere ịwa ahụ obere 2% GSE cream ma ọ bụ placebo. Ndị na-eji ude GSE nwetara ọgwụgwọ ọnya zuru oke mgbe ụbọchị 8 gasịrị, ebe ndị otu placebo were 14 ụbọchị iji gwọọ.

Nsonaazụ a yikarịrị n'ihi ọkwa dị elu nke proanthocyanidins na GSE na-ebute ntọhapụ nke ihe uto na akpụkpọ ahụ ().

N'ime ọmụmụ ihe 8-izu ọzọ na ụmụ okorobịa nwere ahụ ike 110, ihe 2% GSE ude mere ka ọdịdị anụ ahụ dịkwuo mma, na-agbanwe agbanwe, yana ọdịnaya sebum, nke nwere ike inye aka belata akara ngosi nke ịka nká ().

Na nchikota Ude GSE pụtara na-eme ka ihe na-eto eto na akpụkpọ gị. Dị ka ndị dị otú a, ha nwere ike inye aka n'ịgwọ ọnya ma nyere aka belata ihe ịrịba ama nke ịka nká.

Omume puru omume

A na-ele GSE anya dị mma yana enweghi mmetụta ole na ole.

Achọpụtala ihe dị ka 300-800 mg kwa ụbọchị maka izu 8-16 nke ga-adị mma na nke ọma na ụmụ mmadụ ().

Ndị dị ime ma ọ bụ na-enye nwa ara kwesịrị izere ya, ebe ọ bụ na ezughi ezu data banyere mmetụta ya na ndị a.

GSE nwere ike belata ọbara mgbali, belata ọbara gị, ma mee ka ọbara na-erugharị, yabụ, a dọrọ ndị na-a thinụ ọbara ma ọ bụ ọgwụ mgbali elu aka na ntị.

Ọzọkwa, ọ nwere ike belata nsị nke iron, yana melite ọrụ imeju na ọgwụ metabolism. Gakwuru onye na-ahụ maka ahụike tupu iwere ihe mgbakwunye GSE (,).

Na nchikota GSE gosipụtara na-anabata ya nke ọma. Otú ọ dị, ụmụ nwanyị dị ime na ndị na-enye nwa ara kwesịrị izere ya. Ọzọkwa, ndị na-a certainụ ọgwụ ụfọdụ kwesịrị ikwurịta ịnwe mgbakwunye a na ndị ọrụ ahụike ha.

Isi okwu

Mkpụrụ vaịn na-ewepụta (GSE) bụ ihe mgbakwunye na-edozi ahụ sitere na mkpụrụ vaịn.

Ọ bụ ike nke antioxidants, karịsịa proanthocyanidins.

Ndị antioxidants na GSE nwere ike inye aka belata nrụgide oxidative, mbufụt, na mmebi anụ ahụ nwere ike ime n'akụkụ ọrịa na-adịghị ala ala.

Site na ịgbakwunye na GSE, ị ga-erite uru nke obi ka mma, ụbụrụ, akụrụ, imeju, na ahụike anụ ahụ.