Nnyocha mkpụrụ ndụ BRAF
Ndinaya
- Kedu ihe bụ BRAF mkpụrụ ndụ ihe nketa ule?
- Kedu ihe eji ya?
- Gịnị kpatara m ji chọọ nyocha mkpụrụ ndụ BRAF?
- Kedu ihe na-eme n'oge ule mkpụrụ ndụ BRAF?
- Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?
- Onwere ihe egwu di n’ule a?
- Kedu ihe nsonaazụ ahụ pụtara?
- Onwere ihe ozo m choro ima banyere BRAF test?
- Ntughari
Kedu ihe bụ BRAF mkpụrụ ndụ ihe nketa ule?
Nyocha mkpụrụ ndụ BRAF na-achọ mgbanwe, nke a maara dị ka mmụba, na mkpụrụ ndụ ihe nketa a na-akpọ BRAF. Ihe nketa bụ ihe nketa sitere n'aka nne gị na nna gị.
Mkpụrụ ndụ BRAF na-eme protein nke na-enyere aka ịchịkwa uto mkpụrụ ndụ. A maara ya dị ka oncogene. Oncogene na-arụ ọrụ dị ka okpu gas na ụgbọ ala. Dị ka ọ dị, otu oncogene na-agbanye uto sel dị ka ọ dị mkpa. Mana ọ bụrụ na ị nwere ntụgharị BRAF, ọ dị ka pedal gas na-arapara ala, mkpụrụ ndụ ihe nketa enweghị ike ịkwụsị mkpụrụ ndụ na-eto eto. Ọkpụkpụ sel a na - achịkwaghị achịkwa nwere ike ibute ọrịa kansa.
Ọ BRRA na mgbanwe nke BRAF, a ga-eketa nne na nna gị ma ọ bụ nweta ya na nwata. Mmegharị nke na-eme mgbe emechara ndụ na-abụkarị ihe kpatara gburugburu ma ọ bụ site na mmejọ nke na-eme n'ahụ gị n'oge nkewa sel. Ihe nketa nke BRAF dị obere, mana ha nwere ike ibute nnukwu nsogbu ahụike.
Mgbanwe ndị a na - enweta (nke a makwaara dị ka somatic) BRAF bụ ihe a na - ahụkarị. Achọpụtala mmụba ndị a n'ihe dị ka ọkara nke ọrịa melanoma niile, ụdị ọrịa cancer kacha njọ. A na-ahụkarị mgbanwe BRAF na nsogbu ndị ọzọ na ụdị ọrịa kansa dị iche iche, gụnyere ọrịa cancer nke eriri afọ, thyroid, na ovaries. Cancers na mgbanwe BRAF na-adịkarị njọ karịa ndị na-enweghị mmụba.
Aha ndị ọzọ: BRAF gene geneation mutation, Melanoma, BRAF V600 mutation, cobas
Kedu ihe eji ya?
Ule a na-ejikarị achọ maka mgbanwe BRAF na ndị ọrịa nwere melanoma ma ọ bụ ọrịa cancer BRAF ndị ọzọ. Medicinesfọdụ ọgwụ cancer na-arụ ọrụ nke ọma na ndị nwere mmụgharị BRAF. Otu ọgwụ ndị ahụ adịghị arụ ọrụ ma mgbe ụfọdụ dị egwu nye ndị na-enweghị mmụba ahụ.
Enwere ike iji nyocha BRAF hụ ma ọ bụrụ na ị nọ n'ihe ize ndụ maka ọrịa kansa dabere na akụkọ ntolite ezinụlọ yana / ma ọ bụ akụkọ ahụike gị.
Gịnị kpatara m ji chọọ nyocha mkpụrụ ndụ BRAF?
Nwere ike ịchọ nyocha BRAF ma ọ bụrụ na achọpụtala gị na melanoma ma ọ bụ ụdị ọrịa kansa ọzọ. Mara ma ị nwere mmụba ahụ nwere ike inyere onye na-eweta gị aka ịkọwa ọgwụgwọ kwesịrị ekwesị.
Nwekwara ike ịchọ ule a iji hụ ma ị nọ n'ọnọdụ dị elu karịa ịrịa kansa. Ihe ndị dị egwu gụnyere akụkọ gbasara ezinụlọ gbasara ọrịa kansa na / ma ọ bụ nwee ọrịa kansa na nwata. Afọ a kapịrị ọnụ dabere na ụdị ọrịa kansa.
Kedu ihe na-eme n'oge ule mkpụrụ ndụ BRAF?
Imirikiti ule BRAF ka ana eme n’ime usoro akpọrọ tumor biopsy. N'oge biopsy, onye nlekọta ahụike ga-ewepụta obere mpempe akwụkwọ site na ịcha ma ọ bụ ịkpụcha elu etuto ahụ. Ọ bụrụ na onye na-eweta gị chọrọ inyocha akpụ akpụ ahụ n’ime ahụ gị, ọ nwere ike iji agịga pụrụ iche wepụ ihe nlele ahụ.
Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?
Usually na-adịghị mkpa ọ bụla pụrụ iche preparations maka a BRAF ule.
Onwere ihe egwu di n’ule a?
May nwere ike ịnwe ntakịrị ọnya ma ọ bụ ọbara ọgbụgba na saịtị nke biopsy. I nwekwara ike inwe obere ahụ erughị ala na saịtị maka otu ụbọchị ma ọ bụ abụọ.
Kedu ihe nsonaazụ ahụ pụtara?
Ọ bụrụ na ị nwere melanoma ma ọ bụ ụdị ọrịa kansa ọzọ, nsonaazụ ya na-egosi na ị nwere mmụgharị BRAF, onye na-eweta gị nwere ike ịkọwa ọgwụ ndị ezubere iji gbanwee mmụba ahụ. Ọgwụ ndị a nwere ike ịdị irè karịa ọgwụgwọ ndị ọzọ.
Ọ bụrụ na ị nwere melanoma ma ọ bụ ụdị ọrịa kansa ọzọ, nsonaazụ ya na-egosi gị emela nwere mmụgharị, onye na-eweta gị ga-ahuta ụdị ọgwụ dị iche iche iji gwọọ kansa gị.
Ọ bụrụ na ịchọpụtaghị ọrịa kansa na nsonaazụ gị na-egosi na ị nwere mkpụrụ ndụ mkpụrụ ndụ BRAF, ọ adịghị pụtara na ị nwere kansa, mana ị nwere nnukwu nsogbu nke kansa. Mana nyocha ọrịa kansa ugboro ugboro, dị ka nyocha anụ ahụ, nwere ike belata ihe egwu gị. N'oge a na-enyocha akpụkpọ ahụ, onye nlekọta ahụike ga-eleba anya na akpụkpọ ahụ gị dum iji chọpụta maka ntụpọ na uto ndị ọzọ na-enyo enyo.
Gwa onye na - enye gị ọrụ gbasara ihe ndị ọzọ ị ga - eme iji belata ihe egwu gị.
Mụtakwuo maka ule nyocha ụlọ, akara ngosi, na nghọta nsonaazụ.
Onwere ihe ozo m choro ima banyere BRAF test?
Nwere ike ịnụ ka ndị na-eweta gị na-ekwu maka mmụba V600E. E nwere ụdị mmụgharị BRAF dị iche iche. V600E bụ ụdị mgbanwe ụdị BRAF.
Ntughari
- American Cancer Society [Intanet]. Atlanta: American Cancer Society Inc.; c2018. Ọrịa Skin Melanoma; [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.cancer.org/cancer/melanoma-skin-cancer.html
- American Cancer Society [Intanet]. Atlanta: American Cancer Society Inc.; c2018. Oncogenes na tumo na-ebelata mkpụrụ ndụ ihe nketa; [emelitere 2014 Jun 25; akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 4]. E Nweta site na: https://www.cancer.org/cancer/cancer-causes/genetics/genes-and-cancer/oncogenes-tumor-suppressor-genes.html
- American Cancer Society [Intanet]. Atlanta: American Cancer Society Inc.; c2018. Usoro ọgwụgwọ ezubere iche maka Ọrịa Skin Melanoma; [emelitere 2018 Jun 28; akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.cancer.org/cancer/melanoma-skin-cancer/treating/targeted-therapy.html
- Ọrịa Cancer.Net [Intanet]. Alexandria (VA): American Society of Clinical Oncology; C2005–2018. Nnyocha nke ndụ maka Ọrịa Ọrịa Cancer; 2017 Jul [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 4]. E Nweta site na: https://www.cancer.net/navigating-cancer-care/cancer-basics/genetics/genetic-testing-cancer-risk
- Ọrịa Cancer.Net [Intanet]. Alexandria (VA): American Society of Clinical Oncology; C2005–2018. Ghọta ezubere iche ọgwụgwọ; 2018 Mee [zoro aka na 2018 Jul 10]; [ihe dị ka ihuenyo 4]. E Nweta site na: https://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/understanding-targeted-therapy
- Integrated Oncology [Intanet]. Ratorylọ Ọrụ Laboratory nke America; c2018. BRAF Gene Mutation Nyocha; [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 3]. E si na: https://www.integratedoncology.com/test-menu/braf-gene-mutation-analysis/07d322d7-33e3-480f-b900-1b3fd2b45f28
- Nnwale ụlọ nyocha na ntanetị [Intanet]. Washington DC: American Association maka Clinical Chemistry; C2001–2018. Ihe omimi; [emelitere 2017 Jul 10; akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 2]. E Nweta site na: https://labtestsonline.org/glossary/biopsy
- Nnwale ụlọ nyocha na ntanetị [Intanet]. Washington DC: American Association maka Clinical Chemistry; C2001–2018. Nnyocha nke mkpụrụ ndụ ihe nketa maka ọgwụgwọ Ọrịa Cancer ezubere iche; [emelitere 2018 Jul 10; akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 2]. E Nweta site na: https://labtestsonline.org/tests/genetic-tests-targeted-cancer-therapy
- Yolọ Ọgwụ Mayo: Laboratories Mayo Medical [Internet]. Ntọala Mayo maka Mmụta Ahụike na Nnyocha; C1995–2018. Nyocha ID: BRAFT: BRAF Mutation Analysis (V600E), Tumor: Clinical and Interpretive; [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 4]. E Nweta site na: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/35370
- National Cancer Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Nnyocha nke mkpụrụ ndụ maka Syndromes Ọrịa Cancer; [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet
- National Cancer Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. NCI Dictionary of Cancer Terms: Usoro BRAF; [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-gene
- National Cancer Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. NCI Dictionary of Cancer Terms: BRAF (V600E) mgbanwe; [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-v600e-mutation
- National Cancer Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. NCI Dictionary of Cancer Okwu: gene; [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 3]. Odi site na: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
- National Cancer Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. NCI Dictionary of Cancer Okwu: oncogene; [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/oncogene
- NIH US Library nke Ọgwụ: Nkọwapụta etlọ Jenetik [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Mkpụrụ ndụ BRAF; 2018 Jul 3 [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 3]. O nwere site na: https://ghr.nlm.nih.gov/gene/BRAF
- NIH US Library nke Ọgwụ: Nkọwapụta etlọ Jenetik [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Gịnị bụ mkpụrụ ndụ ihe nketa na-esi apụta ma olee otú ngbanwe si apụta ?; 2018 Jul 3 [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 3]. O nwere site na: https://ghr.nlm.nih.gov/primer/mutationsanddisorders/genemutation
- Ihe nchoputa ihe nchoputa [Ntaneti]. Nchọpụta nyocha; c2000–2017. Ule Ule: Melanoma, BRAF V600 Mutation, Cobas: Nduzi Nkọwa; [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 4]. Nweta site na: https://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_BRAF_V600&tabview
- Ihe nchoputa ihe nchoputa [Ntaneti]. Nchọpụta nyocha; c2000–2017. Ule Ule: Melanoma, BRAF V600 Mutation, Cobas: Isi; [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=90956
- Mahadum nke Rochester Medical Center [Internet]. Rochester (NY): Mahadum nke Rochester Medical Center; c2018. Health Encyclopedia: Melanoma: Usoro ọgwụgwọ ezubere iche; [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 2]. E Nweta site na: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=34&contentid=BMelT14
- Ahụike UW [Internet]. Madison (WI): Mahadum nke Wisconsin italslọọgwụ na Clinics Authority; c2018. Ozi Ahụike: Nnyocha anụ ahụ nke Skin maka Skin Cancer: Nnyocha nyocha; [emelitere 2017 May 3; akpọrọ 2018 Jul 18]; [ihe dị ka ihuenyo 2]. Odi site na: https://www.uwhealth.org/health/topic/testdetail/physical-exam/hw206422.html#hw206425UW
- Ahụ ike [Intanet]. Madison (WI): Mahadum nke Wisconsin italslọọgwụ na Clinics Authority; c2018. Ozi Ahụike: Skin Cancer, Melanoma: Isiokwu Nchịkọta; [emelitere 2017 May 3; akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 2]. E Nweta site na: https://www.uwhealth.org/health/topic/major/skin-cancer-melanoma/hw206547.html
- Ahụike UW: American Family Children’s Hospital [Internet]. Madison (WI): Mahadum nke Wisconsin italslọọgwụ na Clinics Authority; c2018. Ahụike mụaka: Biopsy; [akpọrọ 2018 Jul 10]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.uwhealthkids.org/kidshealth/en/parents/biopsy.html/
- Zial J, Hui P. BRAF nyocha mgbanwe na usoro ọgwụgwọ. Ọkachamara Rev Mol Diagn [Internet]. 2012 Mar [zoro aka na 2018 Jul 10]; 12 (2): 127–38. E Nweta site na: https://www.ncbi.nlm.nih.gov/pubmed/22369373
Ejila ozi dị na saịtị a dị ka onye dochie anya nlekọta ahụike ọkachamara ma ọ bụ ndụmọdụ. Kpọtụrụ onye na-ahụ maka ahụike ma ọ bụrụ na ị nwere ajụjụ gbasara ahụike gị.