Odee: Clyde Lopez
OfbọChị Okike: 24 Julai 2021
DatebọChị Mmelite: 11 Jenuari 2025
Anonim
How does Niacin (B3) Work? (+ Pharmacology)
Vidio: How does Niacin (B3) Work? (+ Pharmacology)

Ndinaya

Niacin bụ ụdị vitamin B3. A na - ahụ ya na nri dịka yist, anụ, azụ, mmiri ara ehi, akwa, akwụkwọ nri akwụkwọ ndụ akwụkwọ ndụ na ọka okike. A na-emepụta Niacin na ahụ site na tryptophan, nke a na-ahụ na nri nwere protein. Mgbe a na-ewere ya dị ka mgbakwunye, a na-ahụkarị niacin na vitamin B ndị ọzọ.

Egbula niacin na NADH, niacinamide, inositol nicotinate, IP-6, ma ọ bụ tryptophan. Hụ ndepụta dị iche iche maka isiokwu ndị a.

Nchịkwa ọgwụ nke niacin bụ ndị Foodlọ Ọrụ Na-ahụ Maka Nri na Ọgwụ na United States (FDA) kwadoro maka nnukwu cholesterol na ịbawanye ogo nke otu ụdị ezigbo kọlesterol, nke a maara dị ka HDL. A na-ejikwa ọnụ eme ihe na ọgwụ ọgwụ Niacin n'ọnụ iji gbochie ụkọ vitamin B3 na ọnọdụ metụtara ya dịka pellagra.

Natural Medicines Comprehensive database ọnụego na-arụ ọrụ dabere na ihe akaebe sayensị dịka usoro a si dị: Mmetụta, Ikekwe Ọ Ga-arụpụta Ihe, Ikekwe Ọ Ga-arụpụta Ihe, Ikekwe Ọ Dị Irè, Ikekwe Ọ Dị Irè, Adịghị Eme Ihe, na Ego ezughi ezu iji gosi.

Radị irè maka NIACIN ndị dị ka ndị a:


Ikekwe ọ dị irè maka ...

  • Levelsdị abụba nke cholesterol ma ọ bụ abụba ọbara (dyslipidemia). Thefọdụ ọgwụ na niacin bụ ndị US Food and Drug Administration (FDA) kwadoro ka ha bụrụ ngwaahịa ọgwụ maka ịgwọ oke ogo abụba ọbara. Ngwa ọgwụ ọgwụ ọgwụ ọgwụ ndị a na-abakarị nnukwu ike nke 500 mg ma ọ bụ karịa. Formsdị ọgwụ nri nke niacin na-abịakarị n'ike nke 250 mg ma ọ bụ obere. Ebe ọ bụ na achọrọ ọgwụ dị elu nke niacin nke ọma iji meziwanye ọkwa cholesterol, nri nri nri niacin anaghị adịkarị mma. Niacin nwere ike ijikọta ya na ọgwụ ndị ọzọ na-ebelata kọlestrọl mgbe nri na ị singleụ otu ọgwụ ezughị. Niacin na-eme ka ọkwa kọleji dị mma, mana ọ naghị eme ka ihe gbasara obi dị ka nkụchi obi na ọrịa strok.
  • Ọrịa nke enweghị niacin (pellagra) kpatara. Ndị US Food and Drug Administration (FDA) kwadoro Niacin maka ojiji a. Mana, niacin nwere ike ibute "nzu" (acha uhie uhie, itching, na otughari). Ya mere, ngwaahịa ọzọ, a na-akpọ niacinamide, na-ahọrọ mgbe ụfọdụ n'ihi na ọ naghị akpata mmetụta a.

Ekwe omume irè n'ihi na ...

  • Atsdị abụba ọbara na-adịkarị na ndị nwere HIV / AIDS. Ni seemsụ ọgwụ niacin yiri ka ọ na - eme ka ọkwa abụba ndị dị n’ọbara na abụba ọbara a na - akpọ triglycerides dịkwuo mma n’etiti ndị ọrịa nwere ọnọdụ a.
  • Nchịkọta nke mgbaàmà ndị na-abawanye ohere nke ọrịa shuga, ọrịa obi, na ọrịa strok (ọrịa metabolic). Ni seemsụ ọgwụ niacin yiri ka ọ na-eme ka cholesterol dị oke elu (HDL ma ọ bụ “ezigbo”) ya wee belata ogo abụba ọbara a na-akpọ triglycerides na ndị nwere ọrịa metabolic. Iwere niacin na ọgwụ omega-3 nke nwere fatty acid yiri ka ọ kacha arụ ọrụ.

Adighi ike maka ...

  • Ọrịa obi. Nnyocha dị elu na-egosi na niacin anaghị egbochi nkụchi obi ma ọ bụ ọrịa strok na ndị na-a takeụ ọgwụ iji gbochie ma ọ bụ na-agwọ ọrịa obi. Niacin egosighikwa mbelata ọnwụ. E kwesịghị iji Niacin gwọọ ma ọ bụ gbochie ọrịa obi.

Ezughi oke akaebe iji gosipụta irè maka ...

  • Ikwusi akwara ike (atherosclerosis). Ninụrụ niacin n'ọnụ na ọgwụ ndị a na-akpọ bile acid sequestrants nwere ike ibelata obi ike nke akwara n'ime ụmụ nwoke nwere ọnọdụ a. O yiri ka ọ kacha arụ ọrụ n'ime ụmụ nwoke nwere oke abụba ọbara akpọrọ triglycerides. Ma ị niụ niacin yiri ka ọ ga-ebelata nrụgide akwara na-arịa ndị ọrịa nwere ọnọdụ akpọrọ ọrịa akwara (PAD). Ọzọkwa, niacin anaghị egbochi ihe gbasara obi dịka ọnya obi ma ọ bụ ọrịa strok.
  • Ọrịa Alzheimer. Ndị na-a ofụ nnukwu ọgwụ niacin sitere na nri na multivitamins nwere nsogbu dị ala karịa ịrịa ọrịa Alzheimer karịa ndị na-a niụ ọgwụ niacin. Mana enweghi ihe akaebe na ị takingụ ọgwụ niacin na-enyere aka igbochi ọrịa Alzheimer.
  • Cataracts. Ndị mmadụ na-eri nri dị elu na niacin nwere ike belata ohere ịbịaru cataracts nuklia. Anya nuklia bụ nke kachasị dị na cataract. A maghị mmetụta nke ịationụ ọgwụ niacin.
  • Ọrịa nke eriri afọ nke na-akpata afọ ọsịsa (ọgbụgbọ na ọnyụnyụ). Iri niacin n'ọnụ na-egosi na ọ na-ebelata afọ ọsịsa nke ndị mmadụ na-arịa ọrịa ọgbụgbọ
  • Erectile adịghị arụ ọrụ (ED). Ninweta ọgwụ na-egbu oge na-ehi ụra maka izu 12 yiri ka ọ ga-enyere ndị nwere ED na nnukwu ọkwa lipid aka ka ha ghara inwe mmekọahụ mgbe ha na-enwe mmekọahụ.
  • Akwa phosphate n'ime ọbara (hyperphosphatemia). Ndị nwere ọdịda akụrụ nwere ike ịnwe nnukwu ọbara nke phosphate. Somefọdụ nyocha emere n’oge gara aga na-egosi na ịacinụ niacin nwere ike ibelata ogo ọbara nke phosphate na ndị nwere ọria akụrụ-arụ na ogo ọbara nke phosphate. Mana nyocha ndị ọzọ gosiri na ịacinụ niacin anaghị agbada ọkwa phosphate n’ọbara na ndị na-a medicationsụkwa ọgwụ eji agbada ọkwa phosphate.
  • Mgbochie nke akwara na anya (retinal vein occlusion): Nchọpụta emere na mbụ gosiri na ịacinụ niacin nwere ike ime ka ndị nwere ụdị ọnọdụ a ahụ ụzọ.
  • Ọrịa Sickle cell: Nchọpụta emere na mbido gosiri na ị takingụ niacin anaghị eme ka ogo abụba ndị dị n'ọbara meziwanye ndị mmadụ nwere ọrịa sickle cell.
  • Ihe otutu.
  • Mmanya na-a disorderụ mmanya.
  • Egwuregwu ịgba ọsọ.
  • Ntị mpe-hyperactivity disorder (ADHD).
  • Nsogbu.
  • Dizzziness.
  • Hallucinations nke ọgwụ na-akpata.
  • Migraine.
  • Ọrịa mmegharị ahụ.
  • Ọrịa.
  • Ọnọdụ ndị ọzọ.
A choro ihe akaebe ọzọ iji gosipụta niacin maka ojiji ndị a.

Niacin na-amịrị ahụ ya mgbe ọ gbazee na mmiri wee were ọnụ ya. A na-agbanwe ya na niacinamide ma ọ bụrụ na ewere ya karịa nke anụ ahụ chọrọ.

Achọrọ Niacin maka ọrụ kwesịrị ekwesị nke abụba na shuga na ahụ na iji jigide mkpụrụ ndụ dị mma. Na akwa doses, niacin nwere ike inyere ndị nwere ọrịa obi aka n'ihi mmetụta bara uru ya na nsị. Ọ nwekwara ike melite ogo nke ụfọdụ ụdị abụba a na-akpọ triglycerides n'ime ọbara.

Niacin ụkọ nwere ike ibute ọnọdụ akpọrọ pellagra, nke na-ebute mgbakasị ahụ mmadụ, afọ ọsịsa, na mgbaka. Pellagra bụ ihe a na-ahụkarị na mmalite narị afọ nke iri abụọ, mana ọ bụ ihe a na-ahụkarị ugbu a, ebe ọ bụ na a na-eji nri niacin eme nri ụfọdụ nwere ntụ ọka. A kpochapụrụ Pellagra na ọdịbendị ọdịda anyanwụ.

Ndị mmadụ na-eri nri na-adịghị mma, ị alcoholụbiga mmanya ókè, na ụfọdụ ụdị etuto ahụ na-eto ngwa ngwa nke a na-akpọ akpụ carcinoid nwere ike ịnọ n'ihe egwu maka enweghị niacin. Mgbe e were ya n'ọnụ: Niacin bu O yikarịrị ka ọ dị nchebe maka otutu mmadu mgbe ewere ha nke oma. Ngwaahịa ọgwụ nwere niacin dị mma ma ewere ya dị ka a gwara gị. Nri Niacin nwere ma ọ bụ mgbakwunye niacin dị mma ma ewere ya na obere karịa 35 mcg kwa ụbọchị.

Mmetụta a na-ahụkarị nke niacin bụ mmeghachi omume na-ekpo ọkụ. Nke a nwere ike ibute nsụchalụ, nsị, ọkọ, na acha ọbara ọbara nke ihu, ogwe aka, na obi, yana isi ọwụwa. Malite na obere ọgwụ nke niacin na ị takingụ ọgwụ aspirin 325 mg tupu ọgwụ ọ bụla nke niacin ga-enyere aka iwelata mmeghachi omume na-ekpo ọkụ. Oge ụfọdụ, mmeghachi omume a na-apụ dịka ahụ mmadụ na-eji ọgwụ eme ihe. Mmanya na-egbu egbu nwere ike ime ka iwe iwe ka njọ. Zere ị largeụbiga mmanya ókè mgbe ị na-a niụ mmanya.

Ihe ndị ọzọ na-akpata mmetụta bụ niacin bụ iwe afọ, gas nke eriri afọ, anya ntà, ụfụ ọnụ, na nsogbu ndị ọzọ.

Mgbe a na-a doụ ihe karịrị gram 3 kwa ụbọchị niacin, mmetụta ndị ka njọ pụrụ ibute. Ndị a gụnyere nsogbu imeju, gout, ọnya nke tract digestive, enweghịzi ọhụụ, shuga dị n'ọbara, nkụchi obi, na nsogbu ndị ọzọ dị oke njọ.

Akpachapụ anya na ịdọ aka na ntị:

Ime ime na ara-ara: Niacin bu O yikarịrị ka ọ dị nchebe maka ụmụ nwanyị dị ime na ndị na-enye ara ara mgbe ha na-ewere ọnụ na ọnụego akwadoro. Ọnụ ọgụgụ kachasị nke niacin maka ụmụ nwanyị dị ime ma ọ bụ ndị na-enye ara ara bụ 30 mg kwa ụbọchị maka ụmụ nwanyị nọ n'okpuru afọ 18, na 35 mg maka ụmụ nwanyị karịrị 18.

Mụaka: Niacin bu O yikarịrị ka ọ dị nchebe mgbe a na-eji ọnụ na-atụ aro maka afọ ọ bụla. Ma ụmụaka kwesịrị izere ị niụ ọgwụ nke niacin karịa njedebe elu kwa ụbọchị, nke bụ 10 mg maka ụmụaka 1-3 afọ, 15 mg maka ụmụaka 4-8 afọ, 20 mg maka ụmụaka 9-13 afọ, na 30 mg maka ụmụaka 14-18 afọ.

Ahụhụ: Niacin nwere ike njọ allergies site na-eme ka histamine, chemical kpatara maka nfụkasị mgbaàmà, na-wepụtara.

Ọrịa obi / angina ejighị n'aka: Nnukwu niacin nwere ike ibute ihe ize ndụ nke ịda mbà n'obi mgbe ụfọdụ. Jiri nlezianya mee ihe.

Ọrịa Crohn: Ndị mmadụ na-arịa ọrịa Crohn nwere ike ịnwe ọkwa niacin dị ala ma chọọ mgbakwunye n'oge ọkụ.

Ọrịa shuga: Niacin nwere ike ime ka shuga dị n'ọbara dịkwuo elu. Ndị na-arịa ọrịa shuga na-a niụ niacin kwesịrị iji nlezianya lelee shuga dị n'ọbara ha.

Gallbladder ọrịa: Niacin nwere ike ime ka ọrịa gallbladder ka njọ.

Gout: Nnukwu ego nke niacin nwere ike iweta gout.

Ọrịa akụrụ: Niacin nwere ike ibilite na ndi nwere oria akụrụ. Nke a nwere ike ibute nsogbu.

Ọrịa imeju: Niacin nwere ike ime ka mmebi imeju. Ejila nnukwu ego ma ọ bụrụ na ị nwere ọrịa imeju.

Afọ ma ọ bụ ọnya afọ: Niacin nwere ike ime ka ọnya dịkwuo njọ. Ejila nnukwu ego ma ọ bụrụ na ị nwere ọnya.

Ọbara mgbali elu: Niacin nwere ike belata ọbara mgbali elu ma mee ka ọnọdụ a ka njọ.

Gerywa ahụ: Niacin nwere ike igbochi njikwa shuga ọbara n'oge na mgbe ịwachara ahụ. Kwụsị ị niụ niacin dịkarịa ala izu 2 tupu ịwa ahụ.

Abụba na-echekwa n'akụkụ akwara (akaị xanthomas): Niacin nwere ike ime ka ohere ịrịa ọrịa na xanthomas dịkwuo elu.

Nsogbu thyroid gị: Thyroxine bụ hormone nke na-emepụta thyroid. Niacin nwere ike belata ogo ọbara nke thyroxine. Nke a nwere ike njọ mgbaàmà nke ụfọdụ nsogbu gị thyroid.

Agafeghị oke
Kpachara anya na nchikota a.
Mmanya na-egbu egbu (Ethanol)
Niacin nwere ike ibute nsị na ọkọ. Alcoholụ mmanya na niacin nwere ike ime ka nsị na itching njọ. E nwekwara ụfọdụ nchegbu na ị alcoholụ mmanya na niacin nwere ike ime ka ohere nke imeju imeju dịkwuo elu.
Allopurinol (Zyloprim)
A na-eji Allopurinol (Zyloprim) agwọ gout. Ụ nnukwu niacin nwere ike njọ gout ma belata arụmọrụ nke allopurinol (Zyloprim).
Clonidine (Katapila)
Clonidine na niacin ma ọbara mgbali elu. Niụ niacin na clonidine nwere ike ime ka ọbara mgbali gị dị ala.
Gemfibrozil (Lopid)
Iwere niacin tinyere gemfibrozil nwere ike ibute ahụ ike na ụfọdụ ndị mmadụ. Jiri nlezianya mee ihe.
Ọgwụ maka ọrịa shuga (ọgwụ ndị na-arịa ọrịa shuga)
Iji akwa niacin (ihe dị ka gram 3-4 kwa ụbọchị) nwere ike ime ka shuga dị n'ọbara dịkwuo elu. Site n'ịbawanye shuga dị n'ọbara, niacin nwere ike ibelata arụmọrụ nke ọgwụ ndị na-arịa ọrịa shuga. Nyochaa ọbara shuga gị nke ọma. Enwere ike gbanwee usoro ọgwụgwọ ọgwụ shuga gị.

Fọdụ ọgwụ eji agwọ ọrịa shuga gụnyere glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), metformin (Glucophage), nateglinide (Starlix), repaglinide (Prandin), chlor Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), na ndị ọzọ.
Ọgwụ maka ọbara mgbali elu (ọgwụ antihypertensive)
Iji niacin na-eji ọgwụ ndị na-eme ka ọbara mgbalie belata nwere ike ime ka mmetụta nke ọgwụ ndị a dịkwuo elu, ọ nwere ike belata ọbara mgbali elu nke ukwuu.

Somefọdụ ọgwụ maka ọbara mgbali elu gụnyere captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), na ọtụtụ ndị ọzọ .
Ọgwụ ndị nwere ike imerụ umeji (ọgwụ Hepatotoxic)
Niacin nwere ike imerụ imeju. Nkwado-ịhapụ niacin nkwadebe yiri ka ọ nwere nnukwu ihe egwu. Niakingụ niacin yana ọgwụ nke nwekwara ike imerụ imeju nwere ike ime ka nsogbu imeju mebie. A notụla niacin ma ọ bụrụ na ị na-a medicationụ ọgwụ nwere ike imerụ imeju.

Fọdụ ọgwụ nwere ike imerụ imeju gụnyere acetaminophen (Tylenol na ndị ọzọ), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporano) erythromycin (Erythrocin, Ilosone, ndị ọzọ), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), na ọtụtụ ndị ọzọ.
Ọgwụ nke na - eme ka mkpụkọ ọbara (Anticoagulant / Antiplatelet)
Niacin nwere ike belata mkpụkọ ọbara. Niụ niacin na ọgwụ ndị na-eme ka mkpụcha ọbara nwere ike ime ka ọnya na ọbara ọgbụgba dapụta.

Somefọdụ ọgwụ na-eme ka mkpụkọ ọbara na-egbu oge gụnyere aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), na ndị ọzọ.
Ọgwụ eji eme ihe maka iweda cholesterol (Bile acid sequestrants)
Medicationsfọdụ ọgwụ maka iweda cholesterol a na-akpọ bile acid sequestrants nwere ike ibelata ka niacin anụ ahụ na-amịmi. Nke a nwere ike belata arụmọrụ nke niacin. Were niacin na ọgwụ dịkarịa ala 4-6 awa iche.

Fọdụ n'ime ọgwụ ndị a eji belata cholesterol gụnyere cholestyramine (Questran) na colestipol (Colestid).
Ọgwụ ndị e ji wedata cholesterol (Statins)
Niacin nwere ike imetụta akwara n'ụzọ dị njọ. Medicationsfọdụ ọgwụ ndị e ji wedata cholesterol a na-akpọ statins nwekwara ike imetụta akwara. Iwere ọgwụ niacin yana ọgwụ ndị a nwere ike ibute nsogbu nke nsogbu ahụ ike.

Fọdụ n'ime ọgwụ ndị a eji akwa cholesterol gụnyere rosuvastatin (Crestor), atorvastatin (Lipitor), lovastatin (Mevacor), pravastatin (Pravachol), fluvastatin (Lescol), na simvastatin (Zocor).
Probenecid (Benemid)
A na-eji probenecid agwọ gout. Largeụ nnukwu ọgwụ nke niacin nwere ike njọ gout ma belata arụmọrụ nke probenecid.
Sulfinpyrazone (Anturane)
A na-eji Sulfinpyrazone (Anturane) agwọ gout. Largeụ nnukwu niacin nwere ike njọ gout ma belata arụmọrụ nke sulfinpyrazone (Anturane).
Họdroid gị
Ahụ mmadụ na-emepụta hormones thyroid. Niacin nwere ike ibelata ogo gị thyroid. Iwere niacin na ọgwụ ọgwụ thyroid nwere ike ibelata mmetụta na nsonaazụ nke ọgwụ gị.
Obere
Lezie anya na nchikota a.
Pụ Ọgwụ Aspirin
A na-ejikarị ọgwụ aspirin eme ihe iji belata mmiri ọgwụ nke niacin na-akpata. Nara ọgwụ aspirin dị elu nwere ike ibelata ngwa ngwa ahụ na-ekpochapụ niacin. Nke a nwere ike ibute niacin dị ukwuu na ahụ ma nwee ike ibute nsonaazụ. Otú ọ dị, obere ọgwụ aspirin a na-ejikarị eme ihe maka ọgwụ niacin adịghị ka ọ bụ nsogbu.
Nicotine patch (Nicoderm)
Mgbe ụfọdụ, Niacin nwere ike ibute azịza na ntiri. Ihe nicotine patch nwekwara ike ịkpata nsị na nju anya. Niakingụ niacin ma ọ bụ niacinamide na iji ihe nikotin na-eme ihe nwere ike ime ka ị ghara ị andụbiga mmanya ókè.
Beta-carotene
Nchikota niacin na ọgwụ simvastatin (Zocor) na-ebute HDL (oke njupụta lipoprotein) cholesterol ("ezigbo cholesterol") na ndị nwere ọrịa obi na ọrịa obi na obere HDL. Agbanyeghị, iwere niacin yana ngwakọta nke antioxidants, gụnyere beta-carotene, yiri ka ọ na - egosi ịrị elu a na HDL. Amabeghị ma mmetụta a ọ na - eme ndị na - enweghị ọrịa obi.
Chromium
Iburu niacin na chromium mee ihe nwere ike ibelata shuga dị n'ọbara. Ọ bụrụ na ị na-arịa ọrịa shuga ma were ọgwụ chromium na niacin tinyekọtara ọnụ, nyochaa shuga shuga gị ka ọ ghara ịdalata.
Nkpuru ahihia na mmeju nke puru imebi umeji
Niacin, karịsịa na ogo dị elu nwere ike imebi imeju. Niakingụ niacin na ahịhịa ndị ọzọ ma ọ bụ ihe mgbakwunye nwere ike imerụ imeju nwere ike ime ka ihe egwu a ka njọ. Fọdụ n'ime ngwaahịa ndị a gụnyere androstenedione, borage leaf, chaparral, comfrey, dehydroepiandrosterone (DHEA), germander, kava, pennyroyal oil, red yist, na ndị ọzọ.
Mkpụrụ akwụkwọ na ọgwụ ndị nwere ike belata ọbara mgbali elu
Niacin nwere ike belata ọbara mgbali elu. Iwere niacin na mkpuru ahihia ndi ozo na ihe ndi ozo nke na eme ka obara mgbali ghara idi. Ogwu na ihe ndi ozo nwere ike wedata obara obara bu andrographis, casein peptides, cat’s claw, coenzyme Q10, L-arginine, lycium, stinging nettle, theanine, na ndi ozo.
Mkpụrụ akwụkwọ na ọgwụ nwere ike belata mkpụkọ ọbara
Niacin nwere ike belata mkpụkọ ọbara. Iji niacin tinyere ahihia ndi ozo na ihe ndi ozo nke na egbochi mkpụkọ ọbara nwere ike ime ka ohere igba obara na ufodu ndi mmadu. Herbsfọdụ ahihia ndị ọzọ dị n'ụdị a gụnyere Angelica, clove, danshen, galik, ginger, Panax ginseng, na ndị ọzọ.
Kombucha tii
Enwere ụfọdụ nchegbu na kombucha tii nwere ike ibelata ike nri. Agbanyeghị, ọ dị mkpa ịmụkwu ihe a.
Selenium
Nchikota niacin na ọgwụ simvastatin (Zocor) na-ebute HDL (oke njupụta lipoprotein) cholesterol ("ezigbo cholesterol") na ndị nwere ọrịa obi na ọrịa obi na obere HDL. Agbanyeghị, iwere niacin yana ngwakọta nke antioxidants, gụnyere selenium, yiri ka ọ na - egosi ịrị elu a na HDL. Amabeghị ma mmetụta a ọ na - eme ndị na - enweghị ọrịa obi.
Gbalịa
Tryfọdụ tryptophan sitere na nri nwere ike ịtụgharị ghọọ niacin na ahụ. Ninweta niacin na tryptophan ọnụ nwere ike ịbawanye ọkwa na nsonaazụ nke niacin.
Vitamin C
Nchikota niacin na ọgwụ simvastatin (Zocor) na-ebute HDL (oke njupụta lipoprotein) cholesterol ("ezigbo cholesterol") na ndị nwere ọrịa obi na ọrịa obi na ala HDL. Agbanyeghị, iwere niacin yana ngwakọta nke antioxidants, gụnyere vitamin C, yiri ka ọ na-egosi ịrị elu a na HDL. Amabeghị ma mmetụta a ọ na - eme ndị na - enweghị ọrịa obi.
Vitamin E
Nchikota niacin na ọgwụ simvastatin (Zocor) na-ebute HDL (oke njupụta lipoprotein) cholesterol ("ezigbo cholesterol") na ndị nwere ọrịa obi na ọrịa obi na ala HDL. Agbanyeghị, iwere niacin yana ngwakọta nke antioxidants, gụnyere vitamin E, yiri ka ọ na - egosi ịrị elu a na HDL. Amabeghị ma mmetụta a ọ na - eme ndị na - enweghị ọrịa obi.
Zinc
Ahụ nwere ike ime niacin. Ndị na-adịghị eri nri na-edozi ahụ ma nwee ụkọ niacin, dị ka ndị a asụrụma na-adịghị ala ala, na-emekwu niacin ma ọ bụrụ na ha ewere zinc. Enwere ike inwe nsogbu dị egwu nke metụtara niacin dịka ịcha ọcha na itching ma ọ bụrụ na niacin na zinc jikọtara ọnụ.
Ihe ọ drinksụ Hotụ na-ekpo ọkụ
Niacin nwere ike ibute nsị na itching. Ihe ndị a nwere ike ịbawanye ụba ma ọ bụrụ na ejiri ọgwụ na-ekpo ọkụ na-aacinụ niacin.
A na-amụ usoro ndị a na nyocha sayensị:

NDUL okenye

Site n'ọnụ:
  • General: Somefọdụ ihe mgbakwunye na-edozi ahụ na-edepụta niacin na akara na ntụtụ ndị ọzọ (NE). 1 mg nke niacin bu ihe dika 1 mg NE. Mgbe edepụtara niacin na akara dịka NE, ọ nwere ike ịgụnye ụdị ọgwụ ndị ọzọ, gụnyere niacinamide, inositol nicotinate na tryptophan. A na-enyekarị ndị na-eri nri nri kwa ụbọchị (RDAs) maka ọgwụ nke ndị okenye bụ 16 mg NE maka ụmụ nwoke, 14 mg NE maka ụmụ nwanyị, 18 mg NE maka ụmụ nwanyị dị ime, yana 17 mg NE maka ụmụ nwanyị na-enye ara ara.
  • Maka cholesterol dị elu: Mmetụta nke niacin bụ dose-dabere. Ejila ọgwụ nke niacin dị obere dị ka 50 mg na ihe dị ka gram 12 kwa ụbọchị. Agbanyeghị, mmụba kasịnụ na HDL ma belata na triglycerides na-eme na 1200 ruo 1500 mg / ụbọchị. Mmetụta kasịnụ nke Niacin na LDL na-eme na 2000 ruo 3000 mg / ụbọchị. Niacin a na-ejikarị ọgwụ ndị ọzọ eme ihe maka imeziwanye ọkwa cholesterol.
  • Maka igbochi na ịgwọ ụkọ vitamin B3 na ọnọdụ metụtara ya dị ka pellagra: 300-1000 mg kwa ụbọchị na nkewa ekewa.
  • Maka ịgwọ okirikiri akwara: Doses nke niacin adịla gram iri na abụọ kwa ụbọchị. Agbanyeghị, ejiri ihe dịka 1 ruo 4 grams nke niacin kwa ụbọchị, naanị ya ma ọ bụ yana statins ma ọ bụ bile acid sequestrants (ọgwụ cholesterol na-agbadata ala), ejiri ruo afọ 6.2.
  • Maka ibelata ọnwụ mmiri nke ọnya ọgbụgbọ na-akpata: Ejirila gram abụọ kwa ụbọchị.
  • Maka oke abụba ọbara dị iche iche n'ihi ọgwụgwọ maka HIV / AIDS: Ejirila gram abụọ kwa ụbọchị.
  • Maka ọrịa metabolic: Ewere gram abụọ nke niacin kwa ụbọchị ruo izu iri na isii. N'ọnọdụ ụfọdụ, a na-ewere gram na-eji 2 gram kwa ụbọchị, naanị ya ma ọ bụ nke a, yana gram 4 nke ọgwụ omega-3 ethyl esters (Lovaza, GlaxoSmithKline Pharmaceuticals).
Site na IV:
  • Maka igbochi na ịgwọ ụkọ vitamin B3 na ọnọdụ metụtara ya dị ka pellagra: Ejiri 60 mg nke niacin.
Dị ka a gbara:
  • Maka igbochi na ịgwọ ụkọ vitamin B3 na ọnọdụ metụtara ya dị ka pellagra: Ejiri 60 mg nke niacin.
M .AKA

Site n'ọnụ:
  • General: (RDAs) a na-atụ aro maka nri nri kwa ụbọchị maka niacin na ụmụaka bụ 2 mg NE maka ụmụ aka 0-6 ọnwa, 4 mg NE maka ụmụ ọhụrụ 7-12 ọnwa, 6 mg NE maka ụmụaka 1-3 afọ, 8 mg NE maka ụmụaka 4-8 afọ, 12 mg NE maka ụmụaka 9-13 afọ, 16 mg NE maka ụmụ nwoke 14-18 afọ, na 14 mg NE maka ụmụ agbọghọ 14-18 afọ.
  • Maka igbochi na ịgwọ ụkọ vitamin B3 na ọnọdụ metụtara ya dị ka pellagra: 100-300 mg kwa ụbọchị nke niacin, nke e nyere na usoro kewara.
3-Pyridinecarboxylic Acid, Acide Nicotinique, Acide Pyridine-Carboxylique-3, Anti-Blacktongue Factor, Antipellagra Factor, B Complex Vitamin, Complex de Vitamines B, Facteur Anti-Pellagre, Niacina, Niacine, Nicoseine, Nicotinic Acid, Pellagra Preventor Vitamin B3, Vitamin PP, Vitamina B3, Vitamine B3, Vitamine eyi.

Iji mụtakwuo banyere otú e si dee isiokwu a, biko lee Natural Medicines Comprehensive database usoro.


  1. Anderson TJ, Grégoire J, Pearson GJ, et al. Ndikere Ntuziaka nke Cardiovascular Society nke Canada nke 2016 maka Nchịkwa nke Dyslipidemia maka Mgbochi Ọrịa Cardiovascular na Okenye. Nwere ike J Cardiol. 2016; 32: 1263-1282. Lelee anya.
  2. Nkume NJ, Robinson JG, Lichtenstein AH, et al. Ntuziaka 2013 ACC / AHA banyere ọgwụgwọ cholesterol ọbara iji belata ihe ize ndụ gbasara obi na ndị okenye: mkpesa nke kọleji American Cardiology / American Heart Association na-eduzi ụkpụrụ omume. J Am Coll Cardiol 2014; 63: 2889-934. Lelee anya.
  3. Lloyd-Jones DM, Morris PB, Ballantyne CM, et al. Ihe nyocha ndị ọkachamara ACC 2016 ACC kwadoro na ọrụ nke usoro ọgwụgwọ ndị na-abụghị nke statin maka LDL-cholesterol na-agbada na njikwa nke ọrịa atherosclerotic cardiovascular: ihe akuko nke kọleji American College of Cardiology na-arụ ọrụ gbasara akwụkwọ ndị ọkachamara ọkachamara. J Am Coll nke Cardiol 2016; 68: 92-125. Lelee anya.
  4. Montserrat-de la Paz S, Lopez S, Bermudez B, et al. Mgbakwunye Mmetụta nke ịhapụ ozugbo na nri abụba abụba na nnukwu insulin na ọnọdụ lipid na ndị nwere ọrịa metabolic. J Sci Nri Agric 2018; 98: 2194-200. Lelee anya.
  5. Jenkins DJA, Spence JD, Giovannucci EL, et al. Ekele Ihe mgbakwunye na mineral maka mgbochi na ọgwụgwọ CVD. J Am Coll Cardiol 2018; 71: 2570-84. Lelee anya.
  6. Sahebkar A, Reiner Z, Simental-Mendia LE, Ferretti G, Cicero AF. Mmetụta nke mgbasa-agbatị na-egbu egbu na plasma lipoprotein (a) ọkwa: Nyocha nyocha na meta-nyocha nke ule a na-achịkwa ebe a na-achịkwa. Ọkpụkpụ. 2016-Nov; 65: 1664-78. Lelee anya.
  7. Gaynon MW, Paulus YM, Rahimy E, Alexander JL, Mansour SE. Mmetụta nke ọgwụ niacin na njedebe nke etiti. Graefes Arch Clin Exp Ophthalmol. 2017 Jun; 255: 1085-92. Lelee anya.
  8. Schandelmaier S, Briel M, Saccilotto R, Olu KK, Arpagaus A, Hemkens LG, Nordmann AJ. Niacin maka mgbochi mbụ na nke abụọ nke ihe omume obi. Cochrane Database Syst Rev. 2017 Jun 14; 6: CD009744. Lelee anya.
  9. Lin C, Grandinetti A, Shikuma C, et al. Ekele Mmetụta nke mgbasa ozi agbatịpụrụ na lipoprotein sub-urughuru na-arịa ọrịa nje HIV. Hawaii J Med Ahụike Ọha. 2013 Gị onwe gị; 72: 123-7. Lelee anya.
  10. Scoffone HM, Krajewski M, Zorca S, et al. Mgbakwunye Mmetụta nke ịhapụ-niacin na ọbara lipids na ọrụ endothelial na ndị okenye nwere ọrịa sickle cell analeia na ọkwa dị elu nke oke lipoprotein cholesterol. Abụ J Cardiol. 2013 Nov 1; 112: 1499-504. Lelee anya.
  11. Brunner G, Yang EY, Kumar A, et al. Mmetụta nke mgbanwe egbugbere ọnụ na ọrịa akwara na-arịa ọrịa mgbe a na-anwa ọgwụ mgbochi (ELIMIT). Ọrịa Atherosclerosis. 2013 iri; 213: 371-7. Lelee anya.
  12. Goldie C, Taylor AJ, Nguyen P, McCoy C, Zhao XQ, Preiss D. Niacin ọgwụ na ihe ize ndụ nke ịrịa ọrịa shuga ọhụrụ: nyocha nyocha nke ule a na-achịkwa. Obi. 2016 Feb; 102: 198-203. Lelee anya.
  13. PL Ihe-ederede, Ọrụ nke Ndị Na-abụghị Statins maka Dyslipidemia. Akwụkwọ ozi Pharmacist / Akwụkwọ ozi Prescriber. June 2016; 32: 320601.
  14. Teo KK, Goldstein LB, Chaitman BR, Grant S, Weintraub WS, Anderson DC, Sila CA, Cruz-Flores S, Padley RJ, Kostuk WJ, Boden WE; AIM-AKW InvestKWỌ Nchọpụta. Mgbatị ọgwụ na-egbu egbu na ihe ize ndụ nke ọrịa strok na-arịa ndị ọrịa nwere ọrịa obi: mkparịta ụka Atherothrombosis na Metabolic Syndrome na obere HDL / High Triglycerides: Mmetụta na Nlekọta Ahụ Ike Outwa (AIM-HIGH). Ọkụ. Ọkt 2013; 44: 2688-93. Lelee anya.
  15. Shearer GC, Pottala JV, Hansen SN, Brandenburg V, Harris WS. Mmetụta nke ọgwụ niacin na omega-3 fatty acids na lipids na ọrụ vascular na ọrịa metabolic: ikpe a na-achịkwa n'ọchịchị. J Lipid Mkpebi. 2012 Nov; 53: 2429-35. Lelee anya.
  16. Sazonov V, Maccubbin D, Sisk CM, Canner PL. Mmetụta nke niacin na nsogbu nke ọrịa shuga na-amalite na ọrịa obi na-arịa ndị ọrịa na normoglycaemia na nsogbu glucose dị ngwa. Int J Ahụhụ. 2013 Gị onwe gị; 67: 297-302. Lelee anya.
  17. Philpott AC, Hubacek J, Sun YC, Hillard D, Anderson TJ. Niacin na-eme ka profaịlụ lipid dị mma ma ọ bụghị ọrụ endothelial na ndị ọrịa nwere ọrịa akwara obi na nnukwu ọgwụgwọ statin. Ọrịa Atherosclerosis. 2013 Feb; 226: 453-8. Lelee anya.
  18. Loebl T, Raskin S. Akụkọ akụkọ ọhụụ: nnukwu nsogbu uche uche na-akpata mgbe a gwọchara ya na niacin. Ọrịa Neuropsychiatry Clin Neurosci. 2013 Fall; 25: E14. Lelee anya.
  19. Lavigne PM, Karas RH. Ọnọdụ niacin dị ugbu a na mgbochi ọrịa obi: usoro nyocha na meta-regression. J Am Coll Cardiol. 2013 Jenụwarị 29; 61: 440-6. Lelee anya.
  20. Lakey WC, Greyshock N, Guyton JR. Mmeghachi omume na-adịghị mma nke akwara Achilles na-arịa ọrịa hypercholesterolemic atọ mgbe ọgwụgwọ gwụsịrị ike na niacin na bile acid. J Ọrịa Lipidol. 2013 Mar-Apr; 7: 178-81. Lelee anya.
  21. Kei A, Liberopoulos EN, Mikhailidis DP, Elisaf M. Nkọwa nke ịgbanwee gaa na nke kachasị elu nke rosuvastatin vs. tinye-na nicotinic acid vs. tinye-na fenofibrate maka mbuaha dyslipidaemia. Int J Ahụhụ. 2013 Mee; 67: 412-9. Lelee anya.
  22. Keene D, Ahịa C, Shun-Shin MJ, Francis DP. Mmetụta na ihe gbasara ọrịa obi nke oke lipoprotein dị elu nke ọgwụgwọ ọgwụ, niacin, fibrates, na ndị na-emechi CETP: meta-analysis nke ọnwụnwa a na-achịkwa aghara aghara gụnyere ndị ọrịa 117,411. BMJ. 2014 Jul 18; 349: g4379. Lelee anya.
  23. Ọ YM, Feng L, Huo DM, Yang ZH, Liao YH. Uru na mmerụ nke niacin na ụdị analog ya maka ndị na-arịa ọrịa na-arịa ọrịa akụrụ: nyocha nyocha na meta-nyocha. Int Urol Nephrol. 2014 Febụ; 46: 433-42. Lelee anya.
  24. Guyton JR, Fazio S, Adewale AJ, Jensen E, Tomassini JE, Shah A, Tershakovec AM. Mmetụta nke ịhapụ-niacin na-arịa ọrịa shuga ọhụrụ n'etiti ndị ọrịa hyperlipidemic na-emeso ezetimibe / simvastatin na ikpe a na-achịkwa. Ọrịa shuga. 2012 Gị onwe gị; 35: 857-60. Lelee anya.
  25. Davidson MH, Rooney M, Pollock E, Drucker J, Choy Y. Mmetụta nke colesevelam na niacin na obere lipoprotein cholesterol na glycemic na-achịkwa ndị nwere ọrịa dyslipidemia na nsogbu glucose ngwa ngwa. J Ọrịa Lipidol. 2013 Sep-Ọkt; 7: 423-32. Lelee anya.
  26. Bassan M. A ikpe maka ịhapụ ozugbo. Obi Ume. 2012 Jenụwarị-Feb; 41: 95-8. Lelee anya.
  27. Aramwit P, Srisawadwong R, Supasyndh O. Irè na nchekwa nke ịgbatị nicotinic acid maka iwelata mmiri site na ndị ọrịa hemodialysis. J Nephrol. 2012 Mee-Jun; 25: 354-62. Lelee anya.
  28. Ali EH, McJunkin B, Jubelirer S, Hood W. Niacin kpalitere coagulopathy dị ka ngosipụta nke mgbaasị ime mgbaasị. W V Med J. 2013 Jan-Feb; 109: 12-4 Na-ele ihe anya.
  29. Urberg, M., Benyi, J., na John, R. Hypocholesterolemic mmetụta nke nicotinic acid na mgbakwunye chromium. J Fam.Pract. 1988; 27: 603-606. Lelee anya.
  30. Hendrix, CR, Housh, TJ, Mielke, M., Zuniga, JM, Camic, CL, Johnson, GO, Schmidt, RJ, na Housh, DJ Nnukwu mmetụta nke ihe mgbakwunye caffeine nwere na bench pịa na mgbatị ụkwụ na ike na oge ike gwụrụ n'oge ergometry. J Ike. Cond. Dr. 2010; 24: 859-865. Lelee anya.
  31. Igwe HL, Figge J, Souney PF, et al. Tụnyere nke excretion nke nicotinuric acid mgbe ingestion nke abụọ achịkwa hapụ ntọhapụ nicotinic acid preparations na mmadụ. J Ahụike Pharmacol. 1988 Dec; 28: 1136-40. Lelee anya.
  32. Mrochek JE, Jolley RL, Nwa okorobịa DS, Turner WJ. Mmeghachi omume nke metabolism nke ụmụ mmadụ ingestion nke nicotinic acid na nicotinamide. Chelọ ọgwụ Chem. Ọrịa. 1976; 22: 1821-7. Lelee anya.
  33. Neuvonen PJ, Roivas L, Laine K, Sundholm O. bioavailability nke ntọhapụ ntọhapụ nke usoro nicotinic acid. Br J Ọgwụ Pharmacol. 1991; 32: 473-6. Lelee anya.
  34. Menon RM, Adams MH, González MA, Tolbert DS, Leu JH, Cefali EA. Plasma na mmamịrị pharmacokinetics nke niacin na metabolites site na agbatịpụtara ntọhapụ nke niacin. Int J Clin Pharmacol Ther. 2007; 45: 448-54. Lelee anya.
  35. Karpe F, Frayn KN. Ihe nicotinic acid receptor - usoro ohuru maka ọgwụ ochie. Lancet. 2004; 363: 1892-4. Lelee anya.
  36. Ikpe S, Smith SJ, Zheng YW, et al. Ificationchọpụta mkpụrụ ndụ ihe nketa nke na-agbanwe acyl CoA: diacylglycerol acyltransferase, isi enzyme na njikọ triacylglycerol. Nyocha Natl Acad Sci US A. 1998; 95: 13018-23. Lelee anya.
  37. Ganji SH, Tavintharan S, Zhu D, Xing Y, Kamanna VS, Kashyap ML. Niacin na-agbaghị aka na-egbochi DGAT2 mana ọ bụghị ọrụ DGAT1 na sel HepG2. J Lipid Mkpebi. Ọrịa. 2004; 45: 1835-45. Lelee anya.
  38. Tornvall P, Hamsten A, Johansson J, Carlson LA. Nhazi nke mejupụtara lipoprotein dị oke ala na hypertriglyceridemia site na nicotinic acid. Ọrịa Atherosclerosis. 1990; 84 (2-3): 219-27. Lelee anya.
  39. Morgan JM, Capuzzi DM, Baksh RI, et al. Mmetụta nke mgbasa ozi na-agbasapụ na lipoprotein subclass. Abụ J Cardiol. Ọrịa. 2003; 91: 1432-6. Lelee anya.
  40. Jin FY, Kamanna VS, Kashyap ML. Niacin na-ebelata mwepụ nke oke lipoprotein apolipoprotein A ma na ọ bụghị cholesterol ester site na mkpụrụ ndụ Hep G2. Ntughari maka mbufe njem cholesterol. Onyedikachi Thromb Vasc Biol. Ọrịa. 1997; 17: 2020-8. Lelee anya.
  41. Vincent JE, Zijlstra FJ. Nicotinic acid na-egbochi njikọ thromboxane na platelet. Prostaglandins. Ọrịa. 1978; 15: 629-36. Lelee anya.
  42. Datta S, Das DK, Engelman RM, et al. Idozi usoro myocardial site na nicotinic acid, ngwakọta antilipolytic: usoro ọrụ. Ntọala Cardiol. 1989; 84: 63-76. Lelee anya.
  43. Turjman N, Cardamone A, Gotterer GS, Hendrix TR. Mmetụta nke nicotinic acid na ọnyá ọgbụgbọ na-emetụta ụbụrụ na sodium na-agbanwe agbanwe na oke bekee jejunum. Johns Hopkins Med J. 1980; 147: 209-11. Lelee anya.
  44. Unna K. Nnyocha banyere toxicity na ọgwụ ọgwụ nke nicotinic acid. J Pharmacol gbasaa Ther 1939; 65: 95-103.
  45. Brazda FG na Coulson RA. Mgbu nke acid nicotinic na ụfọdụ ndị sitere na ya. Nyocha Soc Bio Bio Med Med 1946; 62: 19-20.
  46. Chen KK, Rose CL, Robbins EB. Mgbu nke acid nicotinic. Nyocha Soc Bio Bio Med Med 1938; 38: 241-245.
  47. Fraunfelder FW, Fraunfelder FT, Illingworth DR. Mmetụta mmetụta ojoo metụtara ọgwụgwọ niacin. Br J Ophthalmol 1995; 79: 54-56.
  48. Akwụkwọ Litin, Anderson CF. Myopathy metụtara Nicotinic acid: akụkọ banyere ikpe atọ. Am J Ahụike. Lee ihe omimi. 1989; 86: 481-3.
  49. Gharavi AG, Diamond JA, Smith DA, Phillips RA. Ọ bụ myopathy na-akpata Niacin. Abụ J Cardiol. 1994; 74: 841-2. Lelee anya.
  50. O’REILLY PO, CALLBECK MJ, HOFFER A. Nkwado na-ahapụ nicotinic acid (nicospan); mmetụta na ọkwa cholesterol na leukocytes. Nwere ike Med Assoc J. 1959; 80: 359-62. Lelee anya.
  51. Manwa TP, Odom L, Mullins CA. Lactic acidosis jikọtara ya na ọgwụ niacin dị ukwuu. South Med J. 1991; 84: 496-7. Lelee anya.
  52. Agba aja aja WV. Niacin maka ọrịa lipid. Egosi, irè, na nchekwa. Postgrad Ahụike. 1995 Ọgọst; 98: 185-9, 192-3. Lelee anya.
  53. Windler E, Zyriax BC, Bamberger C, Rinninger F, Beil FU. Atụmatụ ugbu a na ọganihu ndị na-adịbeghị anya na ọgwụgwọ nke hypercholesterolemia. Atheroscler Ntinye. Ọrịa. 2009; 10: 1-4. Lelee anya.
  54. Kaijser L, Eklund B, Olsson AG, Carlson LA. Nkesa nke mmetụta nke nicotinic acid na vasodilatation na lipolysis site na prostaglandin synthesis inhibitor, indomethacin, n'ime mmadụ. Ahụike Bio. Ọrịa. 1979; 57: 114-7. Lelee anya.
  55. Eklund B, Kaijser L, Nowak J, Wennmalm A. Prostaglandins na-enye aka na vasodilation nke nicotinic acid kpatara. Prostaglandins. Ọrịa. 1979; 17: 821-30. Lelee anya.
  56. Andersson RG, Aberg G, Brattsand R, Ericsson E, Lundholm L. Nnyocha banyere usoro nke iwepụ nke nicotinic acid kpatara. Acta Pharmacol Toxicol (Copenh). 1977 Jula; 41: 1-10. Lelee anya.
  57. Morgan JM, Capuzzi DM, Guyton JR, et al. Ọgwụgwọ Mmetụta nke Niaspan, Niacin a na-achịkwa-ịhapụ ya, na ndị ọrịa nwere Hypercholesterolemia: Ọnwale a na-achịkwa Ebebo. J Cardiovasc Pharmacol Ther. 1996; 1: 195-202. Lelee anya.
  58. Aronov DM, Keenan JM, Akhmedzhanov NM, et al. Nlekọta ahụike nke ụlọ ọgwụ nke wax-matriks na-akwado-ịhapụ niacin na ndị Russia na hypercholesterolemia. Arch Fam Ahụike. 1996; 5: 567-75. Lelee anya.
  59. Goldberg A, Alagona P Jr, Capuzzi DM, et al. Otutu ogwu na-aru oru ike na nchekwa nke ụdị nke niacin na njikwa nke hyperlipidemia. Abụ J Cardiol. 2000; 85: 1100-5. Lelee anya.
  60. Smith DT, Ruffin JM, na Smith SG. Pellagra meriri ọgwụ nicotinic nke ọma: akụkọ ikpe. JAMA 1937; 109: 2054-2055.
  61. Fouts PJ, Helmer OM, Lepkovsky S, na et al. Ọgwụgwọ pellagra mmadụ na nicotinic acid. Proc Soc Exp Biol Med 1937; 37: 405-407.
  62. Brown BG, Bardsley J, Poulin D, et al. Mgbakwunye Mkpụrụ kwesịrị ekwesị, ọgwụgwọ ọgwụ atọ na niacin, lovastatin, na colestipol iji belata obere cholesterol lipoprotein <100 mg / dl na ndị ọrịa nwere hyperlipidemia na ọrịa akwara obi. Abụ J Cardiol. 1997; 80: 111-5. Lelee anya.
  63. Banyere TA. Agụmakwụkwọ agụmakwụkwọ na ụlọ ọrụ ọgwụ. Prog Neuropsychopharmacol Biol Ọrịa. 2006 Mee; 30: 429-41 Lee ọhụụ.
  64. Lanska DJ. Isi 30: akụkụ akụkọ ihe mere eme nke ọrịa vitamin na-arịa ọrịa na-arịa: vitamin B mmiri na-agbakwụnye. Aka Neurol. Ọrịa. 2010; 95: 445-76. Lelee anya.
  65. Berge KG, Mgbapu PL. Usoro ogwu ogwu: ihe omimi na niacin. Otu nyocha Research Coronary Drug Project. Eur J Clin Pharmacol. 1991; 40 Suppl 1: S49-51. Lelee anya.
  66. Enweghị ndị edepụtara. Clofibrate na niacin na oria obi. JAMA. 1975 Jenụwarị 27; 231: 360-81. Lelee anya.
  67. Henkin Y, Oberman A, Hurst DC, Segrest JP. Niacin laghachiri: nyocha ahụike na ọgwụ dị mkpa mana ejighị ya. Am J Ahụike. 1991; 91: 239-46. Lelee anya.
  68. Henkin Y, Johnson KC, Segrest JP. Sochie na-egbu egbu na-egbu egbu mgbe ịba ọcha n'anya na-akpata ọgwụ site na ntọhapụ nke ntọhapụ. JAMA. 1990; 264: 241-3. Lelee anya.
  69. Etchason JA, Miller TD, Squires RW, et al. Ekele Ọrịa ịba ọcha n'anya nke Niacin na-akpata: mmetụta nwere ike ibute ya ma ọ bụrụ na ị ga-enwe obere mbadamba-oge iji hapụ niacin. Mayo Clin Proc. 1991; 66: 23-8. Lelee anya.
  70. Shakir KM, Kroll S, Aprill BS, Drake AJ 3rd, Eisold JF. Nicotinic acid na-ebelata ọbara thyroid hormone ma na-ejigide ọnọdụ euthyroid. Mayo Clin Proc. 1995; 70: 556-8. Lelee anya.
  71. Drinka PJ. Mgbanwe na thyroid na hepatic ọrụ ule jikọtara ya na njikere nke nkwado-ntọhapụ niacin. Mayo Clin Proc. Ọrịa. 1992; 67: 1206. Lelee anya.
  72. Cashin-Hemphill L, Spencer CA, Nicoloff JT, et al. Mgbakwunye Mgbanwe na ọgwụ thyroid hormonal indices na colestipol-niacin ọgwụ. Ann Intern Med. Ọrịa. 1987; 107: 324-9. Lelee anya.
  73. Dunn RT, Ford MA, Rindone JP, Kwiecinski FA. P Asụ Ọgwụ Aspirin Dị Obere na Ibuprofen Na-Belata Mmeghachi Omume Na-esochi Nchịkwa Niacin. Abụ J Ther. 1995; 2: 478-480. Lelee anya.
  74. Akwụkwọ Litin, Anderson CF. Myopathy metụtara Nicotinic acid: akụkọ banyere ikpe atọ. Am J Ahụike. 1989; 86: 481-3. Lelee anya.
  75. Hexeberg S, Retterstøl K. [Hypertriglyceridemia - nchọpụta nsogbu, ihe egwu na ọgwụgwọ]. Tidsskr Nor Laegeforen. 2004; 124: 2746-9. Lelee anya.
  76. Garnett WR. Mmekọrịta na hydroxymethylglutaryl-coenzyme A inhibctase inhibitors. Am J Ahụ ike Syst Pharm. 1995; 52: 1639-45. Lelee anya.
  77. Gadegbeku CA, Dhandayuthapani A, Shrayyef MZ, Egan BM. Hemodynamic mmetụta nke nicotinic acid infusion na normotensive na hypertensive isiokwu. Am J Hypertens. Ọrịa. 2003; 16: 67-71. Lelee anya.
  78. O'Brien T, Silverberg JD, Nguyen TT. Nicotinic acid-na-ebute nsị metụtara cytopenia ma belata ogo nke thyroxine-binding-globulin. Mayo Clin Proc. Ọrịa. 1992; 67: 465-8. Lelee anya.
  79. N'iji BD, Lavie CJ, Lohmann TP, Genton E. Niacin na-eme ka ihe na-eme ka ihe na-eme ka ihe na-emepụta ihe na-eme ka coagulopathy ghara ịdị. Njikoka Med. Ọrịa. 1992; 152: 861-3. Lelee anya.
  80. Sampathkumar K, Selvam M, Sooraj YS, Gowthaman S, Ajeshkumar RN. Extended release Nicotinic acid - akwukwo eji ekwu okwu banyere njikwa phosphate. Int Urol Nephrol. 2006; 38: 171-4. Lelee anya.
  81. Ng CF, Lee CP, Ho AL, Lee VW. Mmetụta nke niacin na arụ ọrụ erectile na ụmụ nwoke na-ata ahụhụ na erectile na dyslipidemia. J Mmekọahụ Med. Ọrịa. 2011; 8: 2883-93. Lelee anya.
  82. Duggal JK, Singh M, Attri N, et al. Mmetụta nke ọgwụgwọ niacin na nsonaazụ obi na ndị ọrịa nwere ọrịa akwara obi. J Cardiovasc Pharmacol Ther. Ọrịa. 2010; 15: 158-66. Lelee anya.
  83. Carlson LA, Rosenhamer G. Mbelata ọnwụ na Stockholm Ischemic Heart Disease Secondary Prevention Study site na ngwakọta ọgwụgwọ na clofibrate na nicotinic acid. Iwu nke Med Scand. 1988; 223: 405-18. Lelee anya.
  84. Blankenhorn DH, Nessim SA, Johnson RL, et al. Mmetụta bara uru nke colestipol-niacin ọgwụ agwakọtara na atherosclerosis na-arịa ọrịa akwara na ọrịa ịrịa ọrịa obi. JAMA. 1987; 257: 3233-40. Lelee anya.
  85. Nweta WJ, Selzer RH, Hodis HN, et al. Mbelata otu afọ na nyocha ogologo oge nke ọkpụrụkpụ intima-media ọkpụrụkpụ jikọtara ya na colestipol / niacin ọgwụ. Ọkụ. Ọrịa. 1993; 24: 1779-83. Lelee anya.
  86. Blankenhorn DH, Selzer RH, Crawford DW, et al. Mmetụta bara uru nke ọgwụgwọ colestipol-niacin na akwara carotid nkịtị. Abụọ na afọ anọ Mbelata intima-media ọkpụrụkpụ tụrụ site ultrasound. Mgbaghari. Ọrịa. 1993; 88: 20-8. Lelee anya.
  87. Brown BG, Zambon A, Poulin D, et al. Ọzọ Ojiji nke niacin, statins na resins na ndị ọrịa jikọtara hyperlipidemia. Abụ J Cardiol. 1998; 81 (4A): 52B-59B. Lelee anya.
  88. Brown G, Albers JJ, Fisher LD, et al. Mgbakwunye Mmetụta nke ọrịa akwara obi na-akpata n'ihi ọgwụgwọ kpụ ọkụ n'ọnụ na-agbadata na ụmụ nwoke nwere nnukwu apolipoprotein B. N Engl J Med. 1990; 323: 1289-98. Lelee anya.
  89. Bruckert E, Labreuche J, Amarenco P. Meta-nyocha nke mmetụta nke nicotinic acid naanị ma ọ bụ na nchikota na ihe gbasara obi na atherosclerosis. Ọrịa Atherosclerosis. Ọrịa. 2010; 210: 353-61. Lelee anya.
  90. Ndị nledo TD, Grant JM, Nkume RE, et al. Nchoputa ohuru banyere ogwu pellagrins nari isii nke mesiri ike puru iche nikotinic acid na prophylaxis. South Med J 1938; 31: 1231.
  91. Malfait P, Moren A, Dillon JC, et al. Achọpụta nke ọma Ihe ntiwapụ nke ọrịa pellagra metụtara mgbanwe nke nri nri nke niacin n'etiti ndị gbara ọsọ ndụ Mozambique na Malawi. Int J Epidemiol. Ọrịa. 1993; 22: 504-11. Lelee anya.
  92. Gerber MT, Mondy KE, Yarasheski KE, et al. Niacin na ndị bu nje HIV nwere hyperlipidemia na-enweta ọgwụgwọ antiretroviral dị ike. Clin Infect Dis. 2004; 39: 419-25. Lelee anya.
  93. MP Dubé, Wu JW, Aberg JA, et al. Nchebe na nrụpụta ọrụ nke mgbasa ozi na-agbatị maka ọgwụgwọ nke ọrịa dyslipidaemia na ndị ọrịa bu nje HIV: Ọmụmụ Ọrịa AIDS nke Ọrịa A5148. Antivir Ther. 2006; 11: 1081-9. Lelee anya.
  94. Balasubramanyam A, Coraza I, Smith EO, et al. Njikọ nke niacin na fenofibrate na mgbanwe ndụ na-eme ka dyslipidemia na hypoadiponectinemia dịkwuo mma na ndị ọrịa HIV na ọgwụgwọ antiretroviral: nsonaazụ nke "obi dị mma," ikpe a na-achịkwa, nke a na-achịkwa. J Ọgwụ Endocrinol Metab. Ọrịa. 2011; 96: 2236-47. Lelee anya.
  95. Elam MB, Hunninghake DB, Davis KB, et al. Mmetụta nke niacin na lipid na lipoprotein etoju na glycemic akara na ọrịa na-arịa ọrịa shuga na elu akwara ọrịa: na ADMIT ọmụmụ: A randomized ikpe. Ọnwụnwa na-eme ka ọtụtụ mmadụ nwee nsogbu. JAMA. Ọrịa. 2000; 284: 1263-70. Lelee anya.
  96. Charland SL, Malone DC. Amụma nke ihe gbasara ọrịa obi na-akpata mbelata ihe ize ndụ site na mgbanwe egbugbere ọnụ metụtara ọgwụgwọ dị ike dyslipidemia. Ntinye Aka nke Curr. Ọrịa. 2010; 26: 365-75. Lelee anya.
  97. Goldberg AC. Usoro nyocha nke usoro ọmụmụ a na-ejikọtaghị ọnụ na mmetụta nke ịhapụ-niacin na ụmụ nwanyị. Abụ J Cardiol. Ọrịa. 2004; 94: 121-4. Lelee anya.
  98. Maes BD, Hiele MI, Geypens BJ, et al. Na Na Na Na Na Na Na Na Na Na Na Na Na Na Na Na Na Na Mgbanwe ọgwụ na ọgwụ nke ọnya afọ nke siri ike dị ka atụpụtara site na ikuku octanoic acid ume: mmetụta nke erythromycin na propantheline. Olu 1994; 35: 333-7. Lelee anya.
  99. Nkwupụta FDA na ikpe AIM-HIGH. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm256841.htm. (Nabata 3 June 2011).
  100. NIH Akụkọ. NIH na-akwụsị ikpe ahụike na ọgwụgwọ cholesterol. Ọnwa Ise 26, 2011.http://www.nih.gov/news/health/may2011/nhlbi-26.htm. (Nabata 3 June 2011).
  101. PL Ihe-akwukwo, Niacin tinyere Statin iji belata Nsogbu Cardiovascular: AIM-HIGH Study. Akwụkwọ ozi Pharmacist / Akwụkwọ ozi Prescriber. Julaị 2011.
  102. Karthikeyan K, Thappa DM. Pellagra na akpụkpọ. Int J Dermatol 2002; 41: 476-81. Lelee anya.
  103. Hendricks WM. Pellagra na pellagralike dermatoses: etiology, nchọpụta dị iche iche, dermatopathology, na ọgwụgwọ. Semin Dermatol 1991; 10: 282-92. Lelee anya.
  104. Bingham LG, Verma SB. A photodistributed ngwa ngwa. (Nnyocha onwe onye nke American Academy of Dermatology). J Am Acad Dermatol 2005; 52: 929-32.
  105. Nahata MC. Chloramphenicol. Na: Evans WE, Schentag JJ, Jusko WJ (eds). Ejiji Pharmacokinetics metụtara: cikpụrụ nke Nlekọta Ọgwụ Na-agwọ Ọgwụ. Nke atọ ed., Vancouver, WA: Applied Therapeutics, Inc., 1992.
  106. Ding RW, Kolbe K, Merz B, et al. Pharmacokinetics nke mmekọrịta nicotinic acid-salicylic acid. Ọrịa Pharmacol Ther 1989; 46: 642-7. Lelee anya.
  107. Lyon VB, Fairley JA. Anticonvulsant-ekere òkè pellagra. J Am Acad Dermatol 2002; 46: 597-9. Lelee anya.
  108. Kaur S, Goraya JS, Thami GP, Kanwar AJ. Pellagrous dermatitis nke phenytoin (leta) kpatara. Ọrịa Pediatr 2002; 19: 93. Lelee anya.
  109. Wood B, Rademaker M, Oakley A, Wallace J. Pellagra n'ime nwanyị na-eji usoro ọgwụgwọ ọzọ. Australas J Dermatol 1998; 39: 42-4. Lelee anya.
  110. Bender DA, Russell-Jones R. Isoniazid na-emetụta pellagra n'agbanyeghị vitamin B6 supplementation (leta). Lancet 1979; 2: 1125-6. Lelee anya.
  111. Stevens H, Ostlere L, malitere R, et al. Pellagra nke abụọ na 5-fluorouracil. Br J Dermatol 1993; 128: 578-80. Lelee anya.
  112. Swash M, Roberts AH. Ihe enwere ike imebi dika encephalopathy na ethionamide na cycloserine. Tubercle 1972; 53: 132. Lelee anya.
  113. Brooks-Hill RW, Bishop ME, Vellend H. Pellagra-dị ka encephalopathy na-eme ka ọtụtụ ọgwụ ọgwụ sie ike maka ọgwụgwọ nke ọrịa akpa ume n'ihi Mycobacterium avium-intracellulare (leta). Am Rev Nzaghachi 1985; 131: 476. Lelee anya.
  114. Bender DA, Earl CJ, Lees AJ. Mbilata Niacin na ndị ọrịa Parkinson na-agwọ L-dopa, benserazide na carbidopa. Ọrịa Sci 1979; 56: 89-93. . Lelee anya.
  115. Ludwig GD, White DC. Pellagra nke 6-mercaptopurine kpaliri. Ọrịa 1960; 8: 212.
  116. Stratigos JD, Katsambas A. Pellagra: ọrịa ka dị ugbu a. Br J Dermatol 1977; 96: 99-106. Lelee anya.
  117. Jarrett P, Duffill M, Oakley A, Smith A. Pellagra, azathioprine na ọrịa obi na-afụ ụfụ. Ọrịa Exp Dermatol 1997; 22: 44-5. Lelee anya.
  118. Ozi ngwaahịa: Niaspan. Ọgwụ Kos. Chika Okonkwo 2005. A na-enweta ya na www.niaspan.com/professional/content/pdfs/productinfo.pdf. (Nabata 3 March 2006).
  119. Schwab RA, Bachhuber BH. Delirium na lactic acidosis nke ethanol na niacin coingestion kpatara. Am J Emerg Med 1991; 9: 363-5. Lelee anya.
  120. Ito MK. Ọganihu na nghọta na njikwa nke dyslipidemia: iji ọgwụgwọ na-adabere na niacin. Am J Health-Syst Pharm 2003; 60 (bunye 2): s15-21. Lelee anya.
  121. Enweta P, Witztum JL. Lovastatin, nicotinic acid na rhabdomyolysis (leta). Ann Int Med 1988; 109: 597-8. Lelee anya.
  122. Rockwell KA. Mmekọrịta nwere ike ịdị n'etiti niacin na transdermal nicotine (leta). Ann Pharmacother 1993; 27: 1283-4. Lelee anya.
  123. Gillman MA, Sandyk R. Ọrịa nicotinic acid nke sodium valproate (leta) kpatara. S Afr Med J 1984; 65: 986. Lelee anya.
  124. Papa m CM. Niacinamide na acanthosis nigricans (leta). Arch Dermatol 1984; 120: 1281. Lelee anya.
  125. Morris MC, Evans DA, Bianias JL, et al. Na Na Na Na Na Niacin nri na ihe ọghọm nke ịrịa ọrịa Alzheimer yana mmụba nke akpịrị. J Neurol Neurosurg Ọrịa 2004; 75: 1093-99. Lelee anya.
  126. McKenney J. Echiche ọhụrụ banyere iji niacin n'ịgwọ ọrịa lipid. Arch Intern Med 2004; 164: 697-705. Lelee anya.
  127. Isingzụ HDL na Niacin Jiri. Aclọ ọgwụ Pharmacist / Akwụkwọ ozi Prescriber 2004; 20: 200504.
  128. Hoskin PJ, Stratford MR, Saunders MI, et al. Ọgwụgwọ Nchịkwa nke nicotinamide n'oge eserese: pharmacokinetics, dose escalation, na ọgwụ na-egbu egbu. Int J Radiat Oncol Biol Phys 1995; 32: 1111-9. Lelee anya.
  129. Miralbell R, Mornex F, Greiner R, et al. Obi ụtọ Mgbatị redio, carbogen, na nicotinamide na glioblastoma multiforme: akụkọ nke European Organization for Research and Treatment of Cancer trial 22933. J Clin Oncol 1999; 17: 3143-9. Lelee anya.
  130. Anon. Niacinamide Monograph. Alt Med Rev 2002; 7: 525-9. Lelee anya.
  131. Schwartz ML Nnukwu hyperglycemia na-agbanwe agbanwe n'ihi ọgwụgwọ niacin. Arch Int Med 1993; 153: 2050-2. Lelee anya.
  132. Kahn SE, Beard JC, Schwartz MW, et al. Nke a Enwekwu ikike nzuzo B-cell dị ka usoro maka mmegharị nke obere agwaetiti na-eme ka insulin nwee ike iguzogide insulin. Ọrịa shuga 1989; 38: 562-8. Lelee anya.
  133. Rader JI, Calvert RJ, Hathcock JN. Ọrịa na-egbu egbu nke ọgwụ a na-edozi agbanwe na oge ịhapụ nke niacin. Am J Med 1992; 92: 77-81. Lelee anya.
  134. Igwe HL, Figge J, Souney PF, et al. Nicotinic acid: nyocha nke usoro ọgwụgwọ ya na ọgwụgwọ ọrịa lipid. Ọgwụ ọgwụ 1988; 8: 287-94. Lelee anya.
  135. HEkwụ HE, Dujovne CA. Mmekọrịta ọgwụ nke ọgwụ ndị na-agbanwe lipid. Ọgwụ Saf 1998; 19: 355-71. Lelee anya.
  136. Vannucchi H, Moreno FS. Mmekọrịta nke niacin na zinc metabolism na ọrịa na-egbu egbu pellagra. Am J Clin Nutr 1989; 50: 364-9. Lelee anya.
  137. Urberg M, Zemel MB. Ihe akaebe maka mmekọrịta n'etiti chromium na nicotinic acid na njikwa nke ndidi glucose na ụmụ mmadụ meworo agadi. Ọkpụkpụ 1987; 36: 896-9. Lelee anya.
  138. Cheung MC, Zhao XQ, Chait A, et al. Ihe mgbakwunye antioxidant na-egbochi nzaghachi nke HDL na ọgwụ simvastatin-niacin na ndị ọrịa nwere ọrịa akwara obi na obere HDL. Onye na-eme ihe nkiri Thromb Vasc Biol 2001; 21: 1320-6. Lelee anya.
  139. Chesney CM, Elam MB, Ahịa JA, et al. Mmetụta nke niacin, warfarin, na ọgwụgwọ antioxidant na coagulation parameters na ndị ọrịa nwere ọrịa akwara na Arterial Disease Multiple Intervention Trial (ADMIT). Obi M J 2000; 140: 631-6 .. Elele anya.
  140. Wink J, Giacoppe G, King J. Mmetụta nke obere na-dose naicin na lipoprotein dị elu na ndị ọrịa na-agwọ ọrịa statin ogologo oge. Am Obi J 2002; 143: 514-8 .. Elele anya.
  141. Wolfe ML, Vartanian SF, Ross JL, et al. Nchebe na arụmọrụ nke Niaspan mgbe agbakwunyere n'otu usoro maka ọgwụgwọ nke dyslipidemia. Am J Cardiol 2001; 87: 476-9, A7 .. Lelee anya.
  142. Agba aja BG, Zhao XQ, Chait A, et al. Simvastatin na niacin, vitamin antioxidant, ma ọ bụ njikọta maka igbochi ọrịa akwara. N Engl J Med 2001; 345: 1583-93. Lelee anya.
  143. Cumming RG, Mitchell P, Smith W. Diet na cataract: Anya Ugwu Blue Anya. Ọrịa 2000; 10: 450-6. Lelee anya.
  144. Kuroki F, Iida M, Tominaga M, et al. Ọtụtụ ọnọdụ vitamin na ọrịa Crohn. Mmekọrịta na ọrụ ọrịa. Dig Dis Sci 1993; 38: 1614-8. Lelee anya.
  145. Nri na Nutrition Board, Institute of Medicine. Ihe oriri na-eri nri maka Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Acid Pantothenic, Biotin, na Choline. Washington, DC: National Academy Press, 2000. Odikwa na: http://books.nap.edu/books/0309065542/html/.
  146. American Dietetic Association weebụsaịtị. Odikwa na: www.eatright.org/adap1097.html (Nweta 16 July 1999).
  147. Lal SM, Hewett JE, Petroski GF, et al. Mmetụta nke nicotinic acid na lovastatin na ndị na-agwọ ọrịa akụrụngwa: ihe a na-atụ anya, nke a na-ahụkarị, nke a na-akpọ. Am J Akụrụ Dis 1995; 25: 616-22. Lelee anya.
  148. Guyton JR, Goldberg AC, Kreisberg RA, et al. Dị irè nke dosing-atọhapụ naanị abalị na mkpokọta maka hypercholesterolemia. Am J Cardiol 1998; 82: 737-43. Lelee anya.
  149. Vega GL, Grundy SM. Mmeghachi omume Lipoprotein na ọgwụgwọ na lovastatin, gemfibrozil, na nicotinic acid na ndị ọrịa normolipidemic nwere hypoalphalipoproteinemia. Arch Intern Med 1994; 154: 73-82. Lelee anya.
  150. Vacek JL, Dittmeier G, Chiarelli T, et al. Mgbakwunye N'iji tụnyere lovastatin (20 mg) na nicotinic acid (1.2 g) na ọgwụ ọ bụla maka ụdị II hyperlipoproteinemia. Am J Cardiol 1995; 76: 182-4. Lelee anya.
  151. Illingworth DR, Stein EA, Mitchel YB, et al. Mmetụta na-atụnyere nke lovastatin na niacin na isi hypercholesterolemia. A ikpe a gaje ikpe. Arch Intern Med 1994; 154: 1586-95. Lelee anya.
  152. Pozzilli P, Browne PD, Kolb H. Meta-nyochara ọgwụgwọ nicotinamide na ndị ọrịa nwere IDDM n'oge na-adịbeghị anya. Ndị Nicotinamide Trialists. Ọrịa shuga 1996; 19: 1357-63. Lelee anya.
  153. Johansson JO, Egberg N, Asplund-Carlson A, Carlson LA. Usoro ọgwụgwọ Nicotinic acid na-agbanwe nhazi fibrinolytic nke ọma ma na-ebelata plasma fibrinogen na ụmụ nwoke hypertriglyceridaemic. J Cardiovasc Egwu 1997; 4: 165-71. Lelee anya.
  154. Rabbani GH, Butler T, Bardhan PK, Islam A. Mbelata nke mmiri-ọnwụ na cholera site na nicotinic acid: ikpe a na-achịkwa n'ọchịchị. Lancet 1983; 2: 1439-42. Lelee anya.
  155. Mmemme Mmụta Cholesterol Mba. Cholesterol Na-agbadata Ndidi nke Na-arịa Ọrịa Obi. 1997. Odikwa na: http://www.vidyya.com/pdfs/1225cholesterol.pdf. (Nabata 26 May 2016).
  156. Darvay A, Basarab T, McGregor JM, Russell-Jones R. Isoniazid kpaliri pellagra n'agbanyeghị mgbakwunye pyridoxine. Ọrịa Exp Dermatol 1999; 24: 167-9. Lelee anya.
  157. Ishii N, Nishihara Y. Pellagra encephalopathy n'etiti ndị ọrịa tuberculous: mmekọrịta ya na ọgwụgwọ isoniazid. J Neurol Neurosurg Ọrịa 1985; 48: 628-34. Lelee anya.
  158. American Society nke Health-System Pharmacists. ASHP Nkwupụta Ọnọdụ Ọgwụ na iji niacin na njikwa nke dyslipidemias. Am J Health Syst Pharm 1997; 54: 2815-9. Lelee anya.
  159. Leighton RF, Gordon NF, Obere GS, et al. Ọrịa eze na gingival dịka mmetụta dị n'akụkụ ọgwụgwọ niacin. Igbe 1998; 114: 1472-4. Lelee anya.
  160. Garg A, Grundy SM. Nicotinic acid dị ka ọgwụgwọ maka dyslipidemia na ọrịa shuga na-abụghị insulin. JAMA 1990; 264: 723-6. Lelee anya.
  161. Usegha JR III. Ihe ohuru banyere ojiji nke niacin maka ọgwụgwọ hyperlipidemia: echiche ohuru banyere iji ogwu ochie. Ọkpụkpụ Coron Dis 1996; 7: 321-6. Lelee anya.
  162. Nkwanye RH. Nkọwa ahụike nke ụlọ ọgwụ nke Niacin (Niaspan) na usoro physiologic maka dosing abalị. Am J Cardiol 1998; 82: 24U-28U; mkparịta ụka 39U-41U. Lelee anya.
  163. Nchịkọta RH, Alagona P, Davidson M, et al. Ejiri arụ ọrụ nke Niacin (Niaspan) nke a na-enye oge na-adịghị mma na njikwa nke hyperlipidemia. Ọkpụkpụ 1998; 47: 1097-104. Lelee anya.
  164. McKenney JM, Proctor JD, Harris S, Chinchili VM. Nkọwa nke nrụpụta ọrụ na nsị na-egbu egbu nke nkwado na-ahapụ ozugbo na ndị ọrịa hypercholesterolemic. JAMA 1994; 271: 672-7. Lelee anya.
  165. Grey DR, Morgan T, Chretien SD, Kashyap ML. Fficrụ ọrụ na nchekwa nke ịhapụ-ahapụ niacin na ndị agha dyslipoproteinemic. Ann Intern Med 1994; 121: 252-8. Lelee anya.
  166. Capuzzi DM, Guyton JR, Morgan JM, et al. Ekele Nrụpụta ọrụ na nchekwa nke ogologo-hapụ niacin (Niaspan): ọmụmụ ogologo oge. Am J Cardiol 1998; 82: 74-81; diski. 85U-6U. Lelee anya.
  167. Jungnickel PW, Maloley PA, Vander Tuin EL, et al. Naịjirịa Mmetụta nke usoro ọgwụgwọ aspirin abụọ na mmeghachi omume ndị na-akpata niacin. J Gen Intern Med 1997; 12: 591-6. Lelee anya.
  168. Whelan AM, Ọnụ Ahịa, Fowler SF, Hainer BL. Mmetụta nke ọgwụ aspirin na mmeghachi omume ndị na-akpata ọrịa niacin. Omalite Omume 1992; 34: 165-8. Lelee anya.
  169. Gibbons LW, Gonzalez V, Gordon N, Grundy S. Njupụta nke mmetụta dị iche iche na-akwụsị mgbe niile na-ahapụ nicotinic acid. Am J Med 1995; 99: 378-85. Lelee anya.
  170. Ogige YK, Sempos CT, Barton CN, et al. Mmetụta nke nchekwa ihe oriri na United States: ihe banyere pellagra. Am J Ọhaneze 2000; 90: 727-38. Lelee anya.
  171. Zhao XQ, Brown BG, Hillger L, et al. Mmetụta nke ọgwụgwọ kpụ ọkụ n'ọnụ na-agbadata na akwara obi nke akwara nke asymptomatic isiokwu dị elu na apolipoprotein B. Circulation 1993; 88: 2744-53. Lelee anya.
  172. Mgbapu PL, Berge KG, Wenger NK, et al. Ọnwụ afọ iri na ise na Coronary Drug Project ndị ọrịa: uru na-adịte aka na niacin. Nyocha. J Am Coll Cardiol 1986; 8: 1245-55. Lelee anya.
  173. Guyton JR, Na-enwusi MA, Hagar J, et al. Extended-release niacin vs gemfibrozil maka ọgwụgwọ nke ogo nke cholesterol lipoprotein dị elu. Niaspan-Gemfibrozil Study Group. Arch Intern Med 2000; 160: 1177-84. Lelee anya.
  174. Zema MJ. Gemfibrozil, nicotinic acid na ngwakọta ọgwụgwọ na ndị ọrịa nwere hypoalphalipoproteinemia dịpụrụ adịpụ: usoro a na-ahụkarị, nke mepere emepe, ọmụmụ crossover. Nyocha. J Am Coll Cardiol 2000; 35: 640-6. Lelee anya.
  175. Knodel LC, Talbert RL. Mmetụta ọjọọ nke ọgwụ hypolipidaemic. Med Toxicol 1987; 2: 10-32. Lelee anya.
  176. Yates AA, Schlicker SA, Suitor CW. Ihe oriri na-eri nri: Ihe ndabere maka aro maka calcium na nri ndị metụtara ya, vitamin B, na choline. J Am Nri Assoc 1998; 98: 699-706. Lelee anya.
  177. Shils ME, Olson JA, Shike M, Ross AC, eds. Nri nke oge a na Ahụike na Ọrịa. Agba nke 9. Baltimore, MD: Williams & Wilkins, 1999.
  178. Reimund E. Ihi ụra na-akpata dermatitis: nkwado ọzọ nke mbelata nicotinic acid na ụra ụra. 1991; 36: 371-3. Lelee anya.
  179. Ioannides-Demos LL, Christophidis N, et al. Chọpụta ihe na-emetụta mmekọrịta mmekọrịta dị n'etiti mkpụrụ osisi grape na cyclosporine na metabolite na-echebara ndị ọrịa nwere ọrịa autoimmune. J Rheumatol 1997; 24: 49-54. Lelee anya.
  180. Hardman JG, Limbird LL, Molinoff PB, atụ. Manlọ ahịa ọgwụ nke Goodman na Gillman nke ọgwụgwọ, 9th ed. New York, NY: McGraw-Hill, 1996.
  181. Garg R, Malinow MR, Pettinger M, et al. Usoro ọgwụgwọ Niacin na-eme ka ọkwa plasma homocysteine ​​na-abawanye. Obi Obi J 1999; 138: 1082-7. Lelee anya.
  182. Gruenwald J, Brendler T, Jaenicke C. PDR maka ọgwụ ọgwụ. Nke 1 ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  183. McEvoy GK, ed. AHFS Ozi Ọgwụ. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
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