Ebumnuche Factor X

Ebumnuche nke ihe kpatara X (iri) bụ nsogbu na - akpata site na enweghị protein a na - akpọ factor X na ọbara. Ọ na - ebute nsogbu na nsị ọbara (coagulation).

Mgbe ị na-agba obara, usoro ihe na-eme n’ime ahụ nke na - enyere mkpụkọ ọbara aka. A na-akpọ usoro a coagulation cascade. Ọ gụnyere protein pụrụ iche a na-akpọ coagulation, ma ọ bụ ịkpụkọ, ihe. Nwere ike ịnwe ohere dị elu nke ọbara ọgbụgba ma ọ bụrụ na otu ma ọ bụ karịa n'ime ihe ndị a na-efu ma ọ bụ na ha anaghị arụ ọrụ dịka ha kwesịrị.

Ihe X bụ otu ihe dị otú ahụ na-akpata coagulation. Ebube X kpatara mgbe ụfọdụ site na nkwarụ ketara eketa na ihe kpatara X gene. A na-akpọ nke a ihe na-akpata oke X. Ọbara ọgbụgba sitere na nke siri ike ruo na nke siri ike dabere n'etu erughị oke.

Ejighị Factor X ụfụ nwekwara ike ịbụ ọnọdụ ọzọ ma ọ bụ ojiji nke ụfọdụ ọgwụ. A na-akpọ nke a ihe nweta X erughi. Enweta ihe X nke na-ezutekarị. Enwere ike kpatara ya:

• Enweghi vitamin K (umu amuru ohuru nwere vitamin K)
• Mmepụta nke protein na-adịghị mma na anụ ahụ na akụkụ ahụ (amyloidosis)
• Ọrịa imeju siri ike
• Iji ọgwụ na-egbochi mkpụkọ (anticoagulants dị ka warfarin)

Womenmụ nwanyị nwere ụkọ ihe nke X nwere ike ibu ụzọ chọpụta mgbe ha nwere ọbara ọgbụgba nke ịhụ nsọ ha na ọbara ọgbụgba mgbe ha mụsịrị nwa. Enwere ike ibu ụzọ chọpụta ọnọdụ a na ụmụ nwoke amụrụ ọhụrụ ma ọ bụrụ na ha nwere ọbara ọgbụgba nke na-adịru ogologo oge karịa ka a na-ebi ya ugwu.

Mgbaàmà nwere ike ịgụnye nke ọ bụla n'ime ihe ndị a:

• Ọbara ọgbụgba na nkwonkwo
• Ọbara ọgbụgba n'ime akwara
• Bruising mfe
• Ọbara ọgbụgba n'oge ọbara ọbara
• Iche imi akpụkpọ ahụ na-agba ọbara
• Imi imi nke na-anaghị akwụsị ngwa ngwa
• Ọbara ọgbụgba mgbe amụrụ nwa

Ule nke enwere ike ime gunyere:

• Ihe nyocha X
• Oge thromboplastin elekere (PTT)
• Oge Prothrombin (PT)

Enwere ike ịchịkwa ọbara ọgbụgba site n'inweta infravenous (IV) infusions nke plasma ma ọ bụ ụtụtụ nke ihe na-eme ka ọkpụkpụ. Ọ bụrụ na ịnweghị vitamin K, dọkịta gị ga - agwa gị vitamin K ka ị were ọnụ, site na injections n'okpuru anụ ahụ, ma ọ bụ site na akwara (intravenously).

Ọ bụrụ na ị nwere ọrịa ọgbụgba a, hụ na:

• Gwa ndị na-elekọta ahụike gị tupu ịnwe ụdị usoro ọ bụla, gụnyere ịwa ahụ na ọrụ eze.
• Gwa ndị ezinụlọ gị maka na ha nwere ike otu ọrịa ahụ mana ha amabeghị ya.

Ihe ndị a nwere ike ịnyekwu ozi na ụkọ X:

• National Hemophilia Foundation: Ihe ndị ọzọ kpatara - www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies
• Organizationtù Mba Maka Ọrịa Na-adịghị Ahụ --rarediseases.org/rare-diseases/factor-x-deficiency
• NIH Genetics Home Reference - ghr.nlm.nih.gov/condition/factor-x-deficiency Hlọ

Nsonaazụ dị mma ma ọ bụrụ na ọnọdụ ahụ dị nro ma ọ bụ nweta ọgwụgwọ.

Ihe nketa nke X na-erughị ala bụ ọnọdụ ndụ niile.

Echiche maka nnweta ihe kpatara X erughị eru dabere na ihe kpatara ya. Ọ bụrụ na ọ bụ ọrịa imeju kpatara ya, nsonaazụ ya dabere na otu esi agwọ ọrịa imeju gị. Vitaminnara mgbakwunye vitamin K ga-agwọ ụkọ vitamin K. Ọ bụrụ na amyloidosis kpatara ọgba aghara ahụ, enwere ọtụtụ usoro ọgwụgwọ. Dọkịta gị nwere ike ịgwa gị ihe ndị ọzọ.

Oké ọbara ọgbụgba ma ọ bụ ọnwụ mberede nke ọbara (ọbara ọgbụgba) nwere ike ime. Ihe nkwonkwo ahụ nwere ike ịgbanwe na nnukwu ọrịa sitere n'ọtụtụ ọbara.

Nweta enyemaka ahụike mberede ma ọ bụrụ na ịnwe ọbara na-enweghị nkọwa ma ọ bụ oke.

Enweghị mgbochi mgbochi mara maka ụkọ ihe kpatara X. Mgbe enweghi vitamin K bụ ihe kpatara ya, iji vitamin K nwere ike inye aka.

Stuart-Prower ụkọ

• Ọkpụkpụ ọbara
• Ọbara ọbara

Gailani D, Wheeler AP, Neff AT. Ọ bụ ụkọ coagulation kpatara erughị eru. Na: Hoffman R, Benz EJ, Silberstein LE, et al, ndị ọzọ. Hematology: ickpụrụ na Omume. Nke 7. Philadelphia, PA: Elsevier; 2018: isi 137.

JElọ Nzukọ JE. Hemostasis na coagulation ọbara. Na: JElọ Nzukọ JE, ed. Akwụkwọ Guyton na Halllọ Akwụkwọ Ahụike Ahụike. Nke 13. Philadelphia, PA: Elsevier; 2016: isi 37.

Ragni MV. Ọrịa ọgbụgba ọbara: ụkọ ihe kpatara nsogbu. Na: Goldman L, Schafer AI, eds. Ọgwụ Goldman-Cecil. Nke iri abụọ na ise. Philadelphia, PA: Elsevier Saunders; 2016: isi 174.