Otutu endocrine neoplasia (MEN) I

Otutu endocrine neoplasia (MEN) ụdị M bụ ọrịa nke otu ma ọ bụ karịa nke endocrine glands na-arụ ọrụ ma ọ bụ na-etolite etuto. A na-ebufe ya site n'ezinụlọ.

Ọgwụ endocrine na-emetụtakarị gụnyere:

• Pancreas
• Parathyroid
• Ọrịa

MEN M na-akpata ntụpọ dị na mkpụrụ ndụ ihe nketa na-ebu koodu maka protein a na-akpọ menin. Ọnọdụ ahụ na-eme ka etuto ahụ nke glands dị iche iche pụta n’otu onye ahụ, ma ọ bụchaghị n’otu oge.

Nsogbu a nwere ike ime n'oge ọ bụla, ọ na-emetụta ụmụ nwoke na ụmụ nwanyị nha anya. Akụkọ ihe mere eme nke ezinụlọ banyere ọgba aghara a na-ebute ihe egwu gị.

Mgbaàmà na-adịgasị iche site na mmadụ gaa na onye ọzọ, na-adaberekwa na gland gụnyere. Ha nwere ike ịgụnye:

• Ime mgbu
• Nchegbu
• Nwa, tarry stools
• Afu obi mgbe nri
• Ọkụ, ụfụ, ma ọ bụ agụụ erughị ala n'ime elu ma ọ bụ obi ala nke akwara, mmiri ara ehi, ma ọ bụ nri na-ebelata.
• Ibelata mmasị mmekọahụ
• Ike ọgwụgwụ
• Isi ọwụwa
• Enweghị oge ịhụ nsọ (na ụmụ nwanyị)
• Loss nke agụụ
• Ọnwụ ma ọ bụ ntutu ihu (na ụmụ nwoke)
• Mgbanwe echiche ma ọ bụ mgbagwoju anya
• Mgbu mgbu
• Ọgbọ na ọgbụgbọ
• Mmetụta na oyi
• Ọnwụ na-atụghị anya ya
• Nsogbu ọhụụ
• Adịghị ike

Onye nlekọta ahụike ga-eme nyocha anụ ahụ ma jụọ ajụjụ gbasara akụkọ ahụike na mgbaàmà gị. Enwere ike ịme ule ndị a:

• Ọkwa cortisol ọbara
• Nyocha CT nke afọ
• CT scan nke isi
• Na-ebu ọnụ shuga shuga
• Nnwale mkpụrụ ndụ ihe nketa
• Nnwale insulin
• MRI nke afọ
• MRI nke isi
• Ọbara adrenocorticotropic hormone
• Ọbara calcium
• Ọbara follicle na-akpali akpali hormone
• Ọbara gastrin
• Ọbara glucagon
• Ọbara luteinizing hormone
• Ọrịa parathyroid hormone
• Ọbara prolactin
• Ọbara thyroid na-akpali akpali hormone
• Ultrasound nke n'olu

Surwa ahụ iji wepu gland ọrịa na-abụkarị ọgwụgwọ nke nhọrọ. Enwere ike iji ọgwụ a na-akpọ bromocriptine kama ịwa ahụ maka etuto ahụ nke na-ahapụ hormone prolactin.

Parathyroid glands, nke na-achịkwa mmepụta calcium, nwere ike wepu ya. Otú ọ dị, ọ na-esiri ahụ ike ịhazi ọkwa calcium na-enweghị glands ndị a, ya mere mkpochapu parathyroid adịghị eme nke mbụ n'ọtụtụ ọnọdụ.

Ogwu enwere ka ibelata oke mmiri acid nke na emeputa site na etuto (gastrinomas), na ibelata onodu nke onya.

A na-enye ọgwụgwọ ngbanwe nke mmiri n’afọ mgbe ewepụchara gland ma ọ bụ na emepụtaghị homonụ zuru ezu.

Pituitary na etuto parathyroid na-abụkarị ndị na-enweghị nsogbu (benign), mana ụfọdụ etuto ahụ nwere ike bụrụ ọrịa cancer (ajọ ọrịa) wee gbasaa na imeju. Ndị a nwere ike belata ịdị ogologo ndụ.

Mgbaàmà nke ọrịa ọnya afọ, obere shuga dị n'ọbara, calcium n'ụba n'ọbara, na arụ ọrụ ndị a na-akpọ pituitary na-arụkarị nke ọma maka ọgwụgwọ kwesịrị ekwesị.

Mkpụrụ etuto ahụ nwere ike ịlaghachi. Mgbaàmà na nsogbu na-adabere na nke glands. Nlele nlele anya nke onye na-eweta gị dị mkpa.

Kpọọ onye na-eweta ọrụ gị ma ọ bụrụ n ’ịchọrọ ihe mgbaàmà nke MEN M ma ọ bụ nwee akụkọ ntolite ezinụlọ maka ọnọdụ a.

Inyocha ndị ikwu nke ndị nsogbu a metụtara ka akwadoro.

Ọrịa Wermer; Nwoke M

• Ọgwụ endocrine

National Comprehensive Cancer Network weebụsaịtị. Usoro nlekọta ahụike na oncology (NCCN ndu): etuto neuroendocrine. Versiondị 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Emelitere March 5, 2019. Nabata March 8, 2020.

Newey PJ, Thakker RV. Otutu endocrine neoplasia. Na: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Akwụkwọ ọgụgụ Williams nke Endocrinology. Nke iri na anọ. Philadelphia, PA: Elsevier; 2020: isi nke 42.

Nieman LK, Spiegel AM. Nsogbu Polyglandular. Na: Goldman L, Schafer AI, eds. Ọgwụ Goldman-Cecil. Nke 26th. Philadelphia, PA: Elsevier; 2020: isi 218.

Thakker RV. Otutu ụdị endoprine neoplasia 1. Na: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Okenye na Ọrịa edimụaka. Nke 7. Philadelphia, PA: Elsevier Saunders; 2016: isi 148.