TP53 Mkpụrụ ndụ ihe nketa

Ndinaya

• Kedu ihe nyocha mkpụrụ ndụ TP53?
• Kedu ihe eji ya?
• Kedu ihe kpatara m ji chọọ nyocha mkpụrụ ndụ ihe nketa TP53?
• Kedu ihe na - eme n'oge ule mkpụrụ ndụ TP53?
• Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?
• Onwere ihe egwu di n’ule a?
• Kedu ihe nsonaazụ ahụ pụtara?
• Enwere ihe ọ bụla ọzọ m kwesịrị ịma gbasara nnwale TP53?
• Ntughari

Kedu ihe nyocha mkpụrụ ndụ TP53?

Ihe nyocha mkpụrụ ndụ TP53 na-achọ mgbanwe, nke a maara dị ka ngbanwe, na mkpụrụ ndụ ihe nketa a na-akpọ TP53 (protein tumor 53). Ihe nketa bụ ihe nketa sitere n'aka nne gị na nna gị.

TP53 bụ mkpụrụ ndụ ihe nketa nke na-enyere aka ịkwụsị uto nke etuto ahụ. A maara ya dị ka ebelata tumo. Mkpụrụ ụbụrụ na-egbochi ụbụrụ na-arụ ọrụ dị ka brek na ụgbọ ala. Ọ na-etinye "brek" na sel, n'ihi ya, ha anaghị ekewa ngwa ngwa. Ọ bụrụ na ị nwere mmụba TP53, mkpụrụ ndụ ihe nketa nwere ike ọ gaghị enwe ike ijikwa uto nke sel gị. Ọkpụkpụ sel a na - achịkwaghị achịkwa nwere ike ibute ọrịa kansa.

Ntughari TP53 nwere ike keta site na nne na nna gị, ma ọ bụ nweta ya mgbe emechara site na gburugburu ebe obibi ma ọ bụ site na mmejọ nke na-eme n'ahụ gị n'oge nkewa sel.

• A na-amata mmụba TP53 a na-akpọ Li-Fraumeni syndrome.
• Li-Fraumeni syndrome bụ obere mkpụrụ ndụ ihe nketa ọnọdụ na ike dịkwuo gị n'ihe ize ndụ nke ụfọdụ ụdị nke cancer.
• Ọrịa ndị a gụnyere ọrịa kansa, ọrịa ọkpụkpụ, ọrịa kansa ọbara, na ọrịa anụ ahụ dị nro, a na-akpọkwa sarcomas.

Enwetara (nke a makwaara dị ka somatic) mmụba TP53 bụ ihe a na-ahụkarị. Achọpụtala mmụba ndị a n'ihe dịka ọkara nke ọrịa kansa ọ bụla, yana n'ọtụtụ ụdị ọrịa kansa dị iche iche.

Aha ndị ọzọ: TP53 analysis mutation, TP53 full gene analysis, TP53 somatic mutation

Kedu ihe eji ya?

A na-eji ule ahụ chọọ ntụgharị TP53. Ọ bụghị ule a na-eme mgbe niile.A na-enyekarị ya ndị mmadụ dabere na akụkọ ntolite ezinụlọ, mgbaàmà, ma ọ bụ nchọpụta mbụ nke kansa.

Kedu ihe kpatara m ji chọọ nyocha mkpụrụ ndụ ihe nketa TP53?

Nwere ike ịchọ nyocha TP53 ma ọ bụrụ:

• Achọpụtala gị n'ọrịa ọkpụkpụ ma ọ bụ nke dị nro tupu ị gbaa afọ iri anọ na ise
• Achọpụtala gị, ọrịa kansa na-ebute tupu oge ịpụ, ụbụrụ ụbụrụ, ọrịa leukemia, ma ọ bụ ọrịa cancer akpa ume tupu afọ 46
• Had nweela otu etuto ma ọ bụ karịa tupu ị gbaa afọ iri anọ na isii
• Otu onye ma ọ bụ karịa n’ime ndị ezi na ụlọ gị a chọpụtala na ọrịa Li-Fraumeni na / ma ọ bụ nwee ọrịa kansa tupu ha agbaa afọ iri anọ na ise

Ihe ndị a bụ ihe ịrịba ama ị nwere ike ịnwe ngbanwe nke mkpụrụ ndụ TP53.

Ọ bụrụ na achọpụtala na ị nwere kansa na ịnweghị akụkọ ntolite ezinụlọ nke ọrịa ahụ, onye na-ahụ maka ahụike gị nwere ike ịnye nyocha a ka ọ hụ ma mmụba TP53 nwere ike ịkpata kansa gị. Knowingmara ma ị nwere mmụba ahụ nwere ike inyere onye na-eweta gị aka ịhazi usoro ọgwụgwọ ma buo amụma ihe nwere ike ibute ọrịa gị.

Kedu ihe na - eme n'oge ule mkpụrụ ndụ TP53?

A na-emekarị nyocha TP53 na ọbara ma ọ bụ ụmị ọkpụkpụ.

Ọ bụrụ n’ịnwale ule ọbara, onye okacha amara nke ahuike ga ewere obara site na akwara na ogwe aka gi. Mgbe etinyere agịga ahụ, a ga-achịkọta obere ọbara n'ime ule nyocha ma ọ bụ vial. Nwere ike na-eche ntakịrị ihe mgbe agịga na-abanye ma ọ bụ na-apụta. Nke a na-ewe ihe na-erughị nkeji ise.

Ọ bụrụ na ị na-enweta ule ụmị ọkpụkpụ, usoro gị nwere ike ịgụnye usoro ndị a:

• Ga-edina ala n'akụkụ gị ma ọ bụ afọ gị, dabere na ọkpụkpụ a ga-eji nyocha. Imirikiti ule na-agbaji ọkpụkpụ na-ewepụ ọkpụkpụ úkwù.
• A ga-eji akwa kpuchie ahụ gị, nke mere na naanị mpaghara a na-anwale ule na-egosi.
• A ga-eji antiseptik kpochaa saịtị ahụ.
• Ga-enweta ogwu ogwu nke ọgwụ na-agwụ ike. Ọ nwere ike gbaa agba.
• Ozugbo mpaghara ahụ dara ụda, onye nlekọta ahụike ga-ewere ihe nlele ahụ. Ga-agha ụgha nke ukwuu n'oge ule a.
• Onye nlekọta ahụike ga-eji ngwá ọrụ pụrụ iche nke na-atụgharị n'ime ọkpụkpụ iji wepụta ihe atụ nke ụmị ọkpụkpụ. May nwere ike ịnwe nrụgide na saịtị ahụ ka a na-ewere sample ahụ.
• Mgbe ule ahụ gasịrị, onye nlekọta ahụike ga-ekpuchi bandage na saịtị.
• Mee atụmatụ ime ka mmadụ kwọọrọ gị laa n'ụlọ, ebe ọ bụ na a pụrụ inye gị ọgwụ na-eme ka ahụ da gị ụra tupu a nwalee gị, nke pụrụ ime ka ị na-ero ụra.

Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?

Usually naghị achọ nkwadebe pụrụ iche maka ọbara ma ọ bụ ụmị ọkpụkpụ ule.

Onwere ihe egwu di n’ule a?

O nwechaghị ihe egwu dị n’inyocha ọbara. May nwere ike ịnwe obere ihe mgbu ma ọ bụ mmerụ ahụ ebe etinyere agịga ahụ, mana ọtụtụ mgbaàmà na-apụ ngwa ngwa.

Mgbe nyocha ụmị ọkpụkpụ, ị nwere ike ịnwe nkwusi ma ọ bụ ọnya na saịtị ịgba ogwu. Nke a na-apụkarị na ụbọchị ole na ole. Onye na-ahụ maka ahụike gị nwere ike ịkwado ma ọ bụ kwupụta ihe ngbu mgbu iji nyere aka.

Kedu ihe nsonaazụ ahụ pụtara?

Ọ bụrụ na a chọpụtala gị na ọrịa Li-Fraumeni, ọ bụ adịghị pụtara na ị nwere kansa, mana ihe egwu gị dị elu karịa ọtụtụ mmadụ. Mana ọ bụrụ na ị nwere mmụba ahụ, ịnwere ike ịme ihe iji belata ihe egwu gị, dịka:

• Nyocha ọrịa cancer ugboro ugboro. Ọrịa cancer nwere ike ịgwọ karịa mgbe achọtara ya na mbido.
• Ime mgbanwe ndị metụtara ndụ, dị ka ịmega ahụ na iri nri siri ike
• Chemoprevention, ị ofụ ọgwụ ụfọdụ, vitamin, ma ọ bụ ihe ndị ọzọ iji belata ihe egwu ma ọ bụ gbuo oge ịmalite ọrịa kansa.
• Iwepu anụ ahụ "nọ n'ihe ize ndụ"

Usoro ndị a ga-adịgasị iche dabere na akụkọ ahụike gị na nzụlite ezinụlọ gị.

Ọ bụrụ na ị nwere ọrịa kansa na nsonaazụ gị na-egosi mmụba TP53 enwetara (achọpụtara mmụba, mana ị nweghị akụkọ gbasara ezinụlọ nke kansa ma ọ bụ ọrịa Li-Fraumeni), onye na-eweta gị nwere ike iji ozi ahụ nyere aka ịkọ etu ọrịa gị ga - esi tolite ma duzie ọgwụgwọ.

Mụtakwuo maka ule nyocha ụlọ, akara ngosi, na nghọta nsonaazụ.

Enwere ihe ọ bụla ọzọ m kwesịrị ịma gbasara nnwale TP53?

Ọ bụrụ na achọpụtala ma ọ bụ chee na ị nwere ọrịa Li-Fraumeni, ọ nwere ike inyere gị aka ịgwa onye na-enye ndụmọdụ gbasara mkpụrụ ndụ ihe nketa. Onye ndụmọdụ banyere mkpụrụ ndụ ihe nketa bụ ọkachamara a zụrụ azụ na mkpụrụ ndụ ihe nketa na ule mkpụrụ ndụ. Ọ bụrụ na ịnwalebeghị gị, onye ndụmọdụ nwere ike inyere gị aka ịghọta ọghọm na uru elele. Ọ bụrụ na anwalela gị, onye ndụmọdụ ahụ nwere ike inyere gị aka ịghọta nsonaazụ ya wee duzie gị ịkwado ọrụ na akụrụngwa ndị ọzọ.

Ntughari

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Ejila ozi dị na saịtị a dị ka onye dochie anya nlekọta ahụike ọkachamara ma ọ bụ ndụmọdụ. Kpọtụrụ onye na-ahụ maka ahụike ma ọ bụrụ na ị nwere ajụjụ gbasara ahụike gị.