Odee: Clyde Lopez
OfbọChị Okike: 24 Julai 2021
DatebọChị Mmelite: 21 Onwa Disemba 2024
Anonim
Nnwale Pharmacogenetic - ỌGwụ
Nnwale Pharmacogenetic - ỌGwụ

Ndinaya

Gini bu ogwu ogwu ogwu?

Pharmacogenetics, nke a na-akpọkwa pharmacogenomics, bụ ọmụmụ banyere etu mkpụrụ ndụ ihe nketa si emetụta mmeghachi omume ahụ na ọgwụ ụfọdụ. Mkpụrụ ndụ ihe nketa bụ akụkụ nke DNA sitere n’aka nne gị na nna gị. Ha na-ebu ozi na-ekpebi àgwà gị pụrụ iche, dịka ịdị elu na agba anya. Mkpụrụ ndụ ihe nketa gị nwekwara ike imetụta otu otu ọgwụ nwere ike isi dịrị gị mma ma dị irè.

Mkpụrụ ndụ ihe nketa nwere ike ịbụ ihe kpatara otu ọgwụ na otu ọgwụ ga-emetụta ndị mmadụ n'ụzọ dị iche iche. Mkpụrụ ndụ ihe nketa nwekwara ike ịbụ ihe kpatara ụfọdụ ndị ji enwe mmetụta dị egwu na ọgwụ, ebe ndị ọzọ enweghị.

Nlele ọgwụ ogwu na-eleba anya na mkpụrụ ndụ ihe nketa iji nyere aka chọpụta ụdị ọgwụ na usoro onwere ike ịdị gị mma.

Aha ndị ọzọ: pharmacogenomics, pharmacogenomic testing

Kedu ihe eji ya?

Enwere ike iji ọgwụ pharmacogenetic mee ihe iji:

  • Chọpụta ma otu ọgwụ nwere ike ịbara gị uru
  • Chọpụta ihe usoro ọgwụgwọ kacha mma nwere ike ịbụ maka gị
  • Kwuo ma ị ga-enwe mmetụta dị egwu n'akụkụ ọgwụ

Kedu ihe kpatara m ji chọọ nyocha ọgwụ ọgwụ?

Onye na-ahụ maka ahụike gị nwere ike ịnye nyocha ndị a tupu ịmalite ọgwụ ụfọdụ, maọbụ ọ bụrụ na ị na-a medicineụ ọgwụ na-adịghị arụ ọrụ na / ma ọ bụ na-akpata mmetụta ọjọọ.


Nyocha pharmacogenetic bụ naanị maka ọnụọgụ ole na ole nke ọgwụ. N’okpuru ebe a bụ ụfọdụ ọgwụ na mkpụrụ ndụ ihe nketa nke enwere ike ịnwale. (A na-enyekarị aha mkpụrụ akwụkwọ na mkpụrụedemede na nọmba.)

ỌgwụỌdịdị
Warfarin: nke na-adị n’ọbaraCYP2C9 na VKORC1
Plavix, nke na-eme ka ọbara ghaaNXU 222
Mgbochi ịgwọ, ọgwụ akwụkwụNKE165, NZE162
Tamoxifen, ọgwụgwọ maka ọrịa ara ureMBP6
Ọgwụ mgbochi ọrịaNDD3, CYP2D6, CYP2C19, CYP1A2
Ọgwụ maka ntị mwe agharaNJ4
Carbamazepine, ọgwụgwọ maka akwụkwụHLA-B * 1502
Abacavir, ọgwụgwọ maka nje HIVHLA-B * 5701
NkọwaOPRM1
Statins, ọgwụ na-agwọ cholesterol dị eluSLCO1B1
Ọgwụgwọ maka ọrịa leukemia nke nwata na nsogbu ụfọdụ nke autoimmuneTMPT


Kedu ihe na-eme n'oge ule ọgwụ ọgwụ?

A na-anwalekarị ọbara ma ọ bụ asọ mmiri.


Maka ule ọbara, onye okacha amara nke ahuike ga ewere obara site na akwara na ogwe aka gi. Mgbe etinyere agịga ahụ, a ga-achịkọta obere ọbara n'ime ule nyocha ma ọ bụ vial. Nwere ike na-eche ntakịrị ihe mgbe agịga na-abanye ma ọ bụ na-apụta. Nke a na-ewe ihe na-erughị nkeji ise.

Maka ule mmiri, jụọ ndị na-ahụ maka ahụike gị ka ha nye gị ndụmọdụ gbasara otu esi ewepụta ihe nlele gị.

Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?

Usually naghị achọ nkwadebe pụrụ iche maka ule ọbara. Ọ bụrụ na ị na-enweta ule mmiri mmiri, ị gaghị eri, drinkụọ, ma ọ bụ see anwụrụ ọkụ maka 30 nkeji tupu ule ahụ.

Onwere ihe egwu di n’ule a?

O nwechaghị ihe egwu dị n’inyocha ọbara. May nwere ike ịnwe obere ihe mgbu ma ọ bụ mmerụ ahụ ebe etinyere agịga ahụ, mana ọtụtụ mgbaàmà na-apụ ngwa ngwa.

Enweghị nsogbu dị n’inwe ule nwa mmiri.

Kedu ihe nsonaazụ ahụ pụtara?

Ọ bụrụ na a nwalere gị tupu ịmalite ọgwụgwọ, ule ahụ nwere ike igosi ma ọgwụ ọ ga-adị irè yana / maọbụ ọ bụrụ na ị nọ n'ihe egwu maka oke mmetụta dị egwu. Nnyocha ụfọdụ, dị ka nke ọgwụ ụfọdụ na-agwọ epilepsy na HIV, nwere ike igosi ma ị nọ n'ihe egwu maka mmetụta egwu na-eyi ndụ egwu. Ọ bụrụ otu a, onye na-eweta gị ga-agba mbọ ịchọ ọgwụgwọ ọzọ.


Nnwale ndị na-eme tupu na mgbe ị na-agwọ ọrịa nwere ike inyere onye na-ahụ maka ahụike gị aka ịchọpụta ọgwụ kwesịrị ekwesị.

Ọ bụrụ na ị nwere ajụjụ gbasara nsonaazụ gị, gwa ndị ọrụ ahụike gị okwu.

Mụtakwuo maka ule nyocha ụlọ, akara ngosi, na nghọta nsonaazụ.

Onwere ihe ozo ichoro ima banyere ule ogwu ogwu?

A na-eji ọgwụ Pharmacogenetic eme ihe iji chọpụta nzaghachi mmadụ na ọgwụ ụfọdụ. Ọ bụghị otu ihe ahụ ka ule mkpụrụ ndụ ihe nketa. A na-eji ọtụtụ mkpụrụ ndụ ihe nketa na-enyere aka ịchọpụta ọrịa ma ọ bụ nwee ike ibute ọrịa, mata mmekọrịta ezinụlọ, ma ọ bụ mata onye nọ na nchọpụta mpụ.

Ntughari

  1. Hefti E, Blanco J. Documenting Pharmacogenomic Testing with Current Procedure Terminology (CPT) Koodu, Ntụleghachi nke Omume gara aga na nke ugbu a. J AHIMA [Intanet]. 2016 Jan [zoro aka na 2018 Jun 1]; 87 (1): 56–9. Nweta site na: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998735
  2. Nnwale ụlọ nyocha na ntanetị [Intanet]. Washington DC: American Association maka Clinical Chemistry; C2001–2018. Nnwale Pharmacogenetic; [emelitere 2018 Jun 1; akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 2]. E Nweta site na: https://labtestsonline.org/tests/pharmacogenetic-tests
  3. Nnwale ụlọ nyocha na ntanetị [Intanet]. Washington DC: American Association maka Clinical Chemistry; C2001–2018. Eluigwe na Ala nke Ule; [emelitere 2017 Nov 6; akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 2]. E Nweta site na: https://labtestsonline.org/articles/genetic-testing?start=4
  4. Yolọ Ọgwụ Mayo: Centerlọ Ọrụ Maka Nkà Mmụta Onwe Onye [Internet]. Ntọala Mayo maka Mmụta Ahụike na Nnyocha; C1998–2018. Ule Ọgwụ-Gene; [akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 3]. Odi site na: http://mayoresearch.mayo.edu/center-for-individualized-medicine/drug-gene-testing.asp
  5. Yolọ Ọgwụ Mayo: Centerlọ Ọrụ Maka Nkà Mmụta Onwe Onye [Internet]. Ntọala Mayo maka Mmụta Ahụike na Nnyocha; C1998–2018. CYP2D6 / Tamoxifen Pharmacogenomic Lab Nyocha; [akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 5].Odi site na: http://mayoresearch.mayo.edu/center-for-individualized-medicine/cyp2d6-tamoxifen.asp
  6. Yolọ Ọgwụ Mayo: Centerlọ Ọrụ Maka Nkà Mmụta Onwe Onye [Internet]. Ntọala Mayo maka Mmụta Ahụike na Nnyocha; C1998–2018. HLA-B * 1502 / Carbamazepine Pharmacogenomic Nyocha Ule; [akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 4]. Odi site na: http://mayoresearch.mayo.edu/center-for-individualized-medicine/hlab1502-carbamazephine.asp
  7. Yolọ Ọgwụ Mayo: Centerlọ Ọrụ Maka Nkà Mmụta Onwe Onye [Internet]. Ntọala Mayo maka Mmụta Ahụike na Nnyocha; C1998–2018. HLA-B * 5701 / Abacavir Pharmacogenomic Lab Test; [akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 4]. O ga-esi na: http://mayoresearch.mayo.edu/center-for-individualized-medicine/hlab5701-abacavir.asp
  8. Yolọ Ọgwụ Mayo: Laboratories Mayo Medical [Internet]. Ntọala Mayo maka Mmụta Ahụike na Nnyocha; C1995–2018. Nyocha ule: PGXFP: Elekwasị anya Pharmacogenomics Panel: Okwu; [akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.mayomedicallaboratories.com/test-catalog/Specimen/65566
  9. National Cancer Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. NCI Dictionary of Cancer Okwu: gene; [akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q;=gene
  10. National Heart, Lung, na Ọbara Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Nnwale ọbara; [akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.nhlbi.nih.gov/health-topics/blood-tests
  11. NIH National Institute of General Medical Science [Intanet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Ọgwụ ọgwụ; [emelitere 2017 Oct; akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 4]. Nweta ya site na: https://www.nigms.nih.gov/education/Pages/factsheet-pharmacogenomics.aspx
  12. NIH US Library nke Ọgwụ: Nkọwapụta etlọ Jenetik [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Kedu ihe bụ pharmacogenomics ?; 2018 Mee 29 [akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 4]. Nweta ya site na: https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomics
  13. Ahụike UF: Mahadum nke Florida Health [Internet]. Mahadum Florida; c2018. Kedu otu mkpụrụ ndụ ihe nketa gị si emetụta ihe ọgwụ dị mma maka gị; 2016 Jan 11 [emelitere 2018 Jun 1; akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 2]. E si na ya: https://ufhealth.org/blog/how-your-genes-influence-what-medicines-are-right-you
  14. UW Health American Family Hospital (Intanet). Madison (WI): Mahadum nke Wisconsin italslọọgwụ na Clinics Authority; c2018. Ahụike mụaka: Pharmacogenomics; [akpọrọ 2018 Jun 1]; [ihe dị ka ihuenyo 4]. E Nweta site na: https://www.uwhealthkids.org/kidshealth/en/parents/pharmacogenomics.html/

Ejila ozi dị na saịtị a dị ka onye dochie anya nlekọta ahụike ọkachamara ma ọ bụ ndụmọdụ. Kpọtụrụ onye na-ahụ maka ahụike ma ọ bụrụ na ị nwere ajụjụ gbasara ahụike gị.

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