Free Light Chains

Ndinaya

• Kedu ihe nyocha nnwale efu efu?
• Kedu ihe eji ya?
• Kedu ihe kpatara m ji chọọ nnwale ụdọ ọkụ anaghị akwụ ụgwọ?
• Kedu ihe na-eme n'oge nnwale nnwale ọkụ n'efu?
• Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?
• O nwere ihe egwu di n’uche cha cha n’efu?
• Kedu ihe nsonaazụ ahụ pụtara?
• Onwere ihe ozo ichoro ima banyere ule cha cha cha cha?
• Ntughari

Kedu ihe nyocha nnwale efu efu?

Udọ olu ọkụ bụ protein nke mkpụrụ ndụ plasma mere, ụdị mkpụrụ ndụ ọbara ọcha. Mkpụrụ ndụ Plasma na-emekwa immunoglobulins (nje). Immunoglobulins na-enyere aka ichebe ahụ megide ọrịa na ọrịa. Immunoglobulins na-etolite mgbe ụdọ ọkụ jikọtara na agbụ dị arọ, ụdị protein ọzọ. Mgbe agbụ ígwè na-agbụ n'agbụ dị arọ, a maara ha dị ka kee ya agbụ ígwè.

Dị ka ọ na-adịkarị, mkpụrụ ndụ plasma na-eme obere obere agbụ ọkụ ndị na-adịghị agbụ agbụ. Kama nke ahụ, a na-ahapụ ha n'ọbara. A maara agbụ ndị a na-enweghị njikọ n'efu agbụ ígwè.

E nwere ụdị ụdọ nke ọkụ abụọ: lambda na kappa light chains. A free ìhè n'agbụ ule jikoro ego nke lambda na kappa free ìhè n'agbụ ke ọbara. Ọ bụrụ na ọnụọgụ agbụ ọkụ dị elu ma ọ bụ dị ala karịa nke nkịtị, ọ nwere ike ịpụta na ị nwere nsogbu nke sel plasma. Ndị a gụnyere ọtụtụ myeloma, ọrịa kansa nke mkpụrụ ndụ plasma, na amyloidosis, ọnọdụ nke na-ebute mbibi dị egwu nke protein na akụkụ dị iche iche na anụ ahụ.

Aha ndị ọzọ: free kappa / lambda ratio, kappa / lambda quantitative free, freelite, kappa na lambda free chains, immunoglobulin free chains

Kedu ihe eji ya?

A na-eji nnwale ụdọ ọkụ anaghị akwụ ụgwọ iji nyere aka chọpụta ma ọ bụ nyochaa nsogbu mkpụrụ ndụ plasma.

Kedu ihe kpatara m ji chọọ nnwale ụdọ ọkụ anaghị akwụ ụgwọ?

Test nwere ike ịnwale ule a ma ọ bụrụ na ị nwere mgbaàmà nke ọgba aghara nke plasma cell. Dabere na ọrịa plasma ị nwere ike ịnwe na akụkụ akụkụ ahụ metụtara, ihe mgbaàmà gị nwere ike ịgụnye:

• Ọkpụkpụ mgbu
• Ike ọgwụgwụ
• Ọnụ ọgụgụ ma ọ bụ tingling na ogwe aka na ụkwụ
• Ire
• Acha pọpụlị na akpụkpọ

Kedu ihe na-eme n'oge nnwale nnwale ọkụ n'efu?

Onye ọkachamara ahụike ga-ewere ihe nyocha ọbara site na akwara aka gị, jiri obere agịga. Mgbe etinyere agịga ahụ, a ga-achịkọta obere ọbara n'ime ule nyocha ma ọ bụ vial. Nwere ike na-eche ntakịrị ihe mgbe agịga na-abanye ma ọ bụ na-apụta. Nke a na-ewe ihe na-erughị nkeji ise.

Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?

Don’tkwesighi nkwadebe ọ bụla pụrụ iche maka nnwale ụdọ ọkụ n'efu.

O nwere ihe egwu di n’uche cha cha n’efu?

O nwechaghị ihe egwu dị n’inyocha ọbara. May nwere ike ịnwe obere ihe mgbu ma ọ bụ mmerụ ahụ ebe etinyere agịga ahụ, mana ọtụtụ mgbaàmà na-apụ ngwa ngwa.

Kedu ihe nsonaazụ ahụ pụtara?

Nsonaazụ gị ga-egosiputa ego maka agbụ lambda na kappa. Ọ ga-enyekwa a atụnyere n'etiti abụọ. Ọ bụrụ na nsonaazụ gị abụghị nke nkịtị, ọ nwere ike ịpụta na ị nwere nsogbu plasma cell, dị ka:

• Otutu myeloma
• Amyloidosis
• MGUS (monoclonal gammopathy nke amaghi ihe o putara). Nke a bụ ọnọdụ nke ị nwere ogo protein na-adịghị mma. Ọ naghị akpata nsogbu ma ọ bụ mgbaàmà ọ bụla, mana oge ụfọdụ ọ na - amalite otutu myeloma.
• Waldenstrom macroglobulinemia (WM), kansa nke mkpụrụ ndụ ọbara ọcha. Ọ bụ ụdị lymphoma na-abụghị Hodgkin.

Mụtakwuo maka ule nyocha ụlọ, akara ngosi, na nghọta nsonaazụ.

Onwere ihe ozo ichoro ima banyere ule cha cha cha cha?

A na-enyekarị nnwale nnwale ọkụ anaghị akwụ ụgwọ na nnwale ndị ọzọ, gụnyere nyocha ọbara na-enweghị ike iji nyere aka kwado ma ọ bụ chịkwaa nchoputa.

Ntughari

1. American Cancer Society [Intanet]. Atlanta: American Cancer Society Inc.; c2019. Ule iji chọta ọtụtụ Myeloma; [emelitere 2018 Feb 28; akpọrọ 2019 Dec 21]; [ihe dị ka ihuenyo 4]. E Nweta site na: https://www.cancer.org/cancer/multiple-myeloma/detection-diagnosis-staging/testing.html
2. American Cancer Society [Intanet]. Atlanta: American Cancer Society Inc.; c2019. Gịnị bụ Waldenstrom Macroglobulinemia ?; [emelitere 2018 Jul 29; akpọrọ 2019 Dec 21]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.cancer.org/cancer/waldenstrom-macroglobulinemia/about/what-is-wm.html
3. American Society nke Hematology [Internet]. Washington DC: American Society nke Hematology; c2019. Myeloma; [akpọrọ 2019 Dec 21]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.hematology.org/Patients/Cancers/Myeloma.aspx
4. International Myeloma Foundation [Intanet]. North Hollywood (CA): International Myeloma Foundation; Ghọta Freelite na Hevylite Ule; [akpọrọ 2019 Dec 21]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.myeloma.org/sites/default/files/resource/u-freelite_hevylite.pdf
5. Nnwale ụlọ nyocha na ntanetị [Intanet]. Washington DC: American Association maka Clinical Chemistry; C2001–2019. Ọbara Free Light Chains; [emelitere 2019 Oct 24; akpọrọ 2019 Dec 21]; [ihe dị ka ihuenyo 2]. E Nweta site na: https://labtestsonline.org/tests/serum-free-light-chains
6. Yolọ Ọgwụ Mayo [Internet]. Ntọala Mayo maka Mmụta Ahụike na Nnyocha; C1998–2019. Monoclonal gammopathy nke a na-enweghị atụ (MGUS): Mgbaàmà na ihe kpatara ya; 2019 Mee 21; [akpọrọ 2019 Dec 21]; [ihe dị ka ihuenyo 3]. E si na: https://www.mayoclinic.org/diseases-conditions/mgus/symptoms-causes/syc-20352362
7. Yolọ Ọgwụ Mayo: Laboratories Mayo Medical [Internet]. Ntọala Mayo maka Mmụta Ahụike na Nnyocha; C1995–2019. Ule nyocha: FLCP: Immunoglobulin Free Light Chains, ọbara: Clinical and Interpretative; [akpọrọ 2019 Dec 21; [ihe dị ka ihuenyo 4]. E Nweta site na: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/84190
8. National Cancer Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Plasma Cell Neoplasms (Gụnyere ọtụtụ Myeloma) Ọgwụgwọ (PDQ®) -Patient Version; [emelitere 2019 Nov 8; akpọrọ 2019 Dec 21]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.cancer.gov/types/myeloma/patient/myeloma-treatment-pdq
9. National Heart, Lung, na Ọbara Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Nnwale ọbara; [akpọrọ 2019 Dec 21]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.nhlbi.nih.gov/health-topics/blood-tests
10. Mahadum nke Rochester Medical Center [Internet]. Rochester (NY): Mahadum nke Rochester Medical Center; c2019. Health Encyclopedia: Chains Light Light (Ọbara); [akpọrọ 2019 Dec 21]; [ihe dị ka ihuenyo 2]. Nweta ya site na: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=serum_free_light_chains

Ejila ozi dị na saịtị a dị ka onye dochie anya nlekọta ahụike ọkachamara ma ọ bụ ndụmọdụ. Kpọtụrụ onye na-ahụ maka ahụike ma ọ bụrụ na ị nwere ajụjụ gbasara ahụike gị.