Nnyocha nke mkpụrụ ndụ BRCA
Ndinaya
- Kedu ihe bụ BRCA mkpụrụ ndụ ihe nketa ule?
- Kedu ihe eji ya?
- Kedu ihe kpatara m ji chọọ nyocha mkpụrụ ndụ BRCA?
- Kedu ihe na - eme n'oge ule mkpụrụ ndụ BRCA?
- Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?
- Onwere ihe egwu di n’ule a?
- Kedu ihe nsonaazụ ahụ pụtara?
- Onwere ihe ozo ichoro ima banyere BRCA genetic test?
- Ntughari
Kedu ihe bụ BRCA mkpụrụ ndụ ihe nketa ule?
Ihe nyocha mkpụrụ ndụ BRCA na-achọ mgbanwe, nke a maara dị ka mmụba, na mkpụrụ ndụ ihe nketa a na-akpọ BRCA1 na BRCA2. Mkpụrụ ndụ ihe nketa bụ akụkụ nke DNA sitere n’aka nne gị na nna gị. Ha na-ebu ozi na-ekpebi àgwà gị pụrụ iche, dịka ịdị elu na agba anya. Mkpụrụ ndụ ihe nketa na-ahụkwa maka ọnọdụ ahụ ike ụfọdụ. BRCA1 na BRCA2 bụ mkpụrụ ndụ ihe nketa na-echebe mkpụrụ ndụ site na ịme protein na-enyere aka igbochi etuto etolite.
Mgbanwe na mkpụrụ ndụ BRCA1 ma ọ bụ BRCA2 nwere ike ibute mmebi sel nke nwere ike ibute kansa. Womenmụ nwanyị nwere mkpụrụ ndụ BRCA na-agbanwe agbanwe nwere nnukwu ihe ize ndụ nke ịnwe ara ma ọ bụ cancer ovarian. Menmụ nwoke nwere mkpụrụ ndụ BRCA na-agbanwe agbanwe nọ n'ọnọdụ dị elu karịa ịrịa ara ma ọ bụ ọrịa kansa prostate. Ọ bụghị onye ọ bụla ketara mmụba BRCA1 ma ọ bụ BRCA2 ga-arịa kansa. Ihe ndị ọzọ, gụnyere ụdị ndụ gị na gburugburu gị, nwere ike imetụta ọrịa kansa gị.
Ọ bụrụ n’ịchọpụta na ị nwere mmụgharị BRCA, ị ga-enwe ike ime ihe iji kpuchido ahụike gị.
Aha ndị ọzọ: BRCA gene gene, BRCA gene 1, BRCA gene 2, cancer cancer sus gene gene, cancer cancer sus gene gene 2
Kedu ihe eji ya?
A na-eji ule a chọpụta ma ọ bụrụ na ị nwere mgbanwe ntụgharị mkpụrụ ndụ BRCA1 ma ọ bụ BRCA2. Mbufe omumu BRCA nwere ike ime ka i nwekwuo ike ibute kansa.
Kedu ihe kpatara m ji chọọ nyocha mkpụrụ ndụ BRCA?
Achọghị BRCA maka ọtụtụ mmadụ. Mgbanwe mkpụrụ ndụ BRCA dị obere, na-emetụta naanị ihe dịka pasent 0.2 nke ndị bi na U.S. Mana inwere ike ịchọrọ ule a ma ọ bụrụ na ịchọrọ na ị nọ n'ọnọdụ dị elu karịa inwe mmụba ahụ. O yikarịrị ka ị ga-enwe mgbanwe BRCA ma ọ bụrụ na:
- Nwee ma ọ bụ nwee ọrịa ara ure nke achọpụtara tupu ọ dị afọ iri ise
- Nwee ma ọ bụ nwee ọrịa ara ure na ara abụọ
- Nwee ma ọ bụ nwee ọrịa ara na ara ovarian
- Mee ka otu onye ma ọ bụ karịa ezinụlọ gị na-arịa kansa ara
- Mee ka nwoke nwoke nwee kansa ara
- Mee ka onye ikwu mara na ị gbanwee mmachi BRCA
- Bụ ndị Ashkenazi (Eastern European) nna nna ndị Juu. Mgbanwe BRCA dịkarịsịrị na otu a ma e jiri ya tụnyere ọnụ ọgụgụ mmadụ niile. Mgbanwe BRCA na-adịkarị na ndị sitere n'akụkụ ndị ọzọ nke Europe, gụnyere, Iceland, Norway, na Denmark.
Kedu ihe na - eme n'oge ule mkpụrụ ndụ BRCA?
Onye ọkachamara ahụike ga-ewere ihe nyocha ọbara site na akwara aka gị, jiri obere agịga. Mgbe etinyere agịga ahụ, a ga-achịkọta obere ọbara n'ime ule nyocha ma ọ bụ vial. Nwere ike na-eche ntakịrị ihe mgbe agịga na-abanye ma ọ bụ na-apụta. Nke a na-ewe ihe na-erughị nkeji ise.
Ọ dị m mkpa ime ihe ọ bụla iji kwadebe maka ule ahụ?
Don’tkwesighi nkwadebe ọ bụla pụrụ iche maka nyocha BRCA. Ma, ị ga-ebu ụzọ zute onye na-enye ndụmọdụ gbasara mkpụrụ ndụ ihe nketa ka ị mara ma ọ̀ ga-akara gị mma. Onye ndụmọdụ gị nwere ike ịgwa gị gbasara ihe egwu na uru dị na nyocha mkpụrụ ndụ ihe nketa na ihe dị iche iche nwere ike ịpụta.
I kwesịkwara iche echiche banyere inweta ndụmọdụ gbasara mkpụrụ ndụ ihe nketa mgbe a nwalechara gị. Onye ndụmọdụ gị nwere ike ịtụle etu nsonaazụ gị nwere ike isi metụta gị na ezinụlọ gị, ma ahụike ma mmụọ.
Onwere ihe egwu di n’ule a?
O nwechaghị ihe egwu dị n’inyocha ọbara. May nwere ike ịnwe obere ihe mgbu ma ọ bụ mmerụ ahụ ebe etinyere agịga ahụ, mana ọtụtụ mgbaàmà na-apụ ngwa ngwa.
Kedu ihe nsonaazụ ahụ pụtara?
A kọwara ọtụtụ nsonaazụ dị ka ihe na-adịghị mma, nke a na-ejighị n'aka, ma ọ bụ nke dị mma, na-apụtakarị ihe ndị a:
- Nsonaazụ na-adịghị mma pụtara na enweghi mkpụrụ ndụ mkpụrụ ndụ BRCA achọtara, mana ọ pụtaghị na ị gaghị enwe kansa.
- Nsonaazụ a na-ejighị n'aka pụtara ụdị mgbanwe ntụgharị mkpụrụ ndụ BRCA a hụrụ, mana enwere ike ijikọ ya na ọnụọgụ kansa kansa. Nwere ike ịchọ nyocha na / ma ọ bụ nyocha ọzọ ma ọ bụrụ na nsonaazụ gị ejighị n'aka.
- Nsonaazụ dị mma pụtara mmụba na BRCA1 ma ọ bụ BRCA2 achọtara. Mgbanwe ndị a na-eme ka ị nọrọ n’ihe ize ndụ dị ukwuu nke ịrịa kansa. Mana ọ bụghị onye ọ bụla nwere mmụba na-enweta kansa.
Ọ nwere ike were ọtụtụ izu iji nweta nsonaazụ gị. Ọ bụrụ na ị nwere ajụjụ gbasara nsonaazụ gị, gwa ndị ọrụ ahụike gị na / ma ọ bụ onye ndụmọdụ mkpụrụ ndụ ihe nketa gị.
Mụtakwuo maka ule nyocha ụlọ, akara ngosi, na nghọta nsonaazụ.
Onwere ihe ozo ichoro ima banyere BRCA genetic test?
Ọ bụrụ n ’nsonaazụ gị gosiri na ị nwere mgbanwe mkpụrụ ndụ BRCA, ị nwere ike ịme ihe ga - eme ka ịnwe ọrịa kansa ara. Ndị a gụnyere:
- Ule a na-anwale ule kansa kansa ugboro ugboro, dịka mammogram na ultrasounds. Ọrịa cancer dị mfe ịgwọ mgbe achọtara ya na mmalite.
- Akingụ ọgwụ mgbochi nwa maka obere oge. Akingakingụ ọgwụ mgbochi ịmụ nwa ihe ruru afọ ise egosila iji belata ihe ize ndụ nke ịrịa ọrịa ovarian na ụfọdụ ụmụ nwanyị nwere mgbanwe mkpụrụ ndụ BRCA. A naghị atụ aro ịillsụ ọgwụ maka ihe karịrị afọ ise iji belata kansa. Ọ bụrụ na ị na-a controlụ ọgwụ mgbochi nwa tupu i lee ule BRCA, gwa onye nlekọta ahụike gị afọ ole ị dị mgbe ị malitere ị theụ ọgwụ ndị a na ogologo oge. Onye ahụ ga - agwa gị ma ị ga - anọgide na - ewere ha.
- Na-a medicinesụ ọgwụ na-alụ ọgụ kansa. Egosiputara ogwu ufodu dika nke a na akpo tamoxifen iji belata onodu umuaka ndi nwere oria cancer ara.
- Inwe ịwa ahụ, nke a maara dịka mastectomy mgbochi, iji wepu anụ ahụ dị mma. Egosiputa mastectomy na-egbochi iji belata ihe ize ndụ nke kansa ara dị ka ihe ruru pasent 90 na ụmụ nwanyị nwere mkpụrụ ndụ BRCA. Mana nke a bụ isi ọrụ, naanị akwadoro maka ụmụ nwanyị nwere nnukwu nsogbu maka ịnwe kansa.
Kwesịrị ịkpọtụrụ onye na-elekọta ahụike gị ka ị hụ ihe ndị kacha mma maka gị.
Ntughari
- American Society of Clinical Oncology [Intanet]. American Society nke Clinical Oncology; 2005-2018. Ọrịa Cancer na Ovarian Cancer; [akpọrọ 2018 Mar 19]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.cancer.net/cancer-types/hereditary-breast-and-ovarian-cancer
- Hinkle J, Cheever K. Brunner & Suddarth's Akwụkwọ ntuziaka nke Laboratory na Diagnostic Tests. 2nd Ed, Kindle. Philadelphia: Wolters Kluwer Health, Lippincott Williams & Wilkins; c2014. Ule BRCA; 108 peeji nke
- Nnwale ụlọ nyocha na ntanetị [Intanet]. Washington DC: American Association maka Clinical Chemistry; C2001–2018. BRCA Gene Mutation Ule [emelitere 2018 Jan 15; zoro aka na 2018 Feb 23]; [ihe dị ka ihuenyo 2]. E Nweta site na: https://labtestsonline.org/tests/brca-gene-mutation-testing
- Yolọ Ọgwụ Mayo [Internet]. Ntọala Mayo maka Mmụta Ahụike na Nnyocha; C1998–2018. BRCA nyocha ule maka ara na ovarian cancer; 2017 Dec 30 [akpọrọ 2018 Feb 23]; [ihe dị ka ihuenyo 3]. Odi na site na: https://www.mayoclinic.org/tests-procedures/brca-gene-test/about/pac-20384815
- Slolọ Ọrịa Cancer Memorial Sloan Kettering [Internet]. New York: Ebe Ncheta Sloan Kettering Ọrịa Cancer; c2018. BRCA1 na BRCA2 Genes: Risk for Breast and Ovarian Cancer [nke e kwuru na 2018 Feb 23]; [ihe dị ka ihuenyo 5]. O nwere site na: https://www.mskcc.org/cancer-care/risk-assessment-screening/hereditary-genetics/genetic-counseling/brca1-brca2-genes-risk-breast-ovarian
- National Cancer Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Mgbanwe BRCA: Nsogbu Ọrịa Cancer na Nnwale Ọrịa [akpọrọ 2018 Feb 23]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet#q1
- National Cancer Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. NCI Dictionary of Cancer Terms: mgbanwe [akpọrọ 2018 Feb 23]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q;=mutation
- National Heart, Lung, na Ọbara Institute [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Nnwale ọbara [akpọrọ 2018 Feb 23]; [ihe dị ka ihuenyo 3]. E Nweta site na: https://www.nhlbi.nih.gov/health-topics/blood-tests
- NIH US Library nke Ọgwụ: Nkọwapụta etlọ Jenetik [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Mkpụrụ ndụ BRCA1; 2018 Mar 13 [akpọrọ 2018 Mar 18]; [ihe dị ka ihuenyo 3]. Nweta ya site na: https://ghr.nlm.nih.gov/gene/BRCA1#condition
- NIH US Library nke Ọgwụ: Nkọwapụta etlọ Jenetik [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Mkpụrụ ndụ BRCA2; 2018 Mar 13 [akpọrọ 2018 Mar 18]; [ihe dị ka ihuenyo 3]. O nwere site na: https://ghr.nlm.nih.gov/gene/BRCA2#condition
- NIH US Library nke Ọgwụ: Nkọwapụta etlọ Jenetik [Internet]. Bethesda (MD): Ngalaba Ahụ Ike na Ọrụ Ndị Ọrụ U.S. Gịnị bụ mkpụrụ ndụ ihe nketa ?; 2018 Feb 20 [akpọrọ 2018 Feb 23]; [ihe dị ka ihuenyo 3]. Nweta ya site na: https://ghr.nlm.nih.gov/primer/basics/gene
- Mahadum nke Rochester Medical Center [Internet]. Rochester (NY): Mahadum nke Rochester Medical Center; c2018. Encyclopedia Health: BRCA [akpọrọ 2018 Feb 23]; [ihe dị ka ihuenyo 2]. E Nweta site na: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid;=brca
- Ahụike UW [Internet]. Madison (WI): Mahadum nke Wisconsin italslọọgwụ na Clinics Authority; c2018. Ọrịa ara ara (BRCA) Gene Ule: Otu esi akwadebe [emelitere 2017 Jun 8; zoro aka na 2018 Feb 23]; [ihe dị ka ihuenyo 5]. O ga-enweta site na: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu6465
- Ahụike UW [Internet]. Madison (WI): Mahadum nke Wisconsin italslọọgwụ na Clinics Authority; c2018. Ọrịa ara ara (BRCA) Gene Ule: Nsonaazụ [emelitere 2017 Jun 8; zoro aka na 2018 Feb 23]; [ihe dị ka ihuenyo 9]. O ga-enweta site na: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu6469
- Ahụike UW [Internet]. Madison (WI): Mahadum nke Wisconsin italslọọgwụ na Clinics Authority; c2018. Ọrịa ara ara (BRCA) Gene Ule: Nnwale Ule [emelitere 2017 Jun 8; zoro aka na 2018 Feb 23]; [ihe dị ka ihuenyo 2]. E si na: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html
- Ahụike UW [Internet]. Madison (WI): Mahadum nke Wisconsin italslọọgwụ na Clinics Authority; c2018. Ọrịa ara ara (BRCA) Gene Ule: Ihe kpatara eji eme ya [emelitere 2017 Jun 8; zoro aka na 2018 Feb 23]; [ihe dị ka ihuenyo 4]. E si na: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu646
Ejila ozi dị na saịtị a dị ka onye dochie anya nlekọta ahụike ọkachamara ma ọ bụ ndụmọdụ. Kpọtụrụ onye na-ahụ maka ahụike ma ọ bụrụ na ị nwere ajụjụ gbasara ahụike gị.