Nyocha Pyruvate kinase

Nnwale pyruvate kinase na-atụ ogo enzyme pyruvate kinase n'ọbara.

Pyruvate kinase bụ enzyme dị na mkpụrụ ndụ ọbara uhie. Ọ na - enyere aka ịgbanwe shuga n'ime ọbara (glucose) ka ọ bụrụ ume mgbe ọkwa oxygen dị ala.

Achọrọ nlebara ọbara. Na laabu ahụ, a na-ewepụ mkpụrụ ndụ ọbara ọcha site na ọbara n'ihi na ha nwere ike ịgbanwe nsonaazụ ule. Mgbe ahụ, atụlee ọkwa nke pyruvate kinase.

Ọ dịghị nkwadebe pụrụ iche dị mkpa.

Ọ bụrụ na nwa gị na-anwale ule a, ọ ga - enyere aka ịkọwa etu ule ga - adị ma gosipụta ya na nwa bebi. Kọwaa ihe kpatara ule ahụ. Knowingmara “otu na ihe kpatara” nwere ike belata nchekasị nke nwa gị.

Mgbe etinyere agịga ahụ iji see ọbara, ụfọdụ ndị na-enwe oke mgbu. Ndị ọzọ na-eche nanị ịpị ma ọ bụ gbaa. Mgbe nke ahụ gasịrị, enwere ike ịkụ ọkpọ ma ọ bụ merụọ ahụ obere. Nke a ga - apụ n'anya.

A na-anwale ule a iji chọpụta ọkwa dị ala nke pyruvate kinase. N’enweghi oke enzyme a, mkpụrụ ndụ uhie uhie na-agbari ngwa ngwa karịa ka ọ dị. Nke a ka akpọrọ anaemia hemolytic.

Nnwale a na-enyere aka ịchọpụta erughị eru kinase pyruvate (PKD).

Nsonaazụ dị iche dabere na usoro nnwale eji. N'ozuzu, otu ọnụahịa bụ 179 ± 16 nkeji kwa 100 mL nke mkpụrụ ndụ ọbara uhie.

Usoro ntanetị dị iche iche nwere ike ịdịtụ iche n'etiti ụlọ nyocha dị iche iche. Lafọdụ labs na-eji nha dị iche iche ma ọ bụ nwalee ụdị dị iche iche. Gwa onye na - enye gi ahu ike banyere ihe nlere gi putara.

Ọkwa dị ala nke pyruvate kinase na-akwado PKD.

E nwere obere ihe ize ndụ gụnyere ịnara ọbara gị. Akwara na akwara na-adịgasị iche site na otu onye gaa na onye ọzọ na site n'otu akụkụ nke ahụ gaa na nke ọzọ. Nara ụfọdụ ndị mmadụ nwere ike isi ike karịa ndị ọzọ.

Ihe ize ndụ ndị ọzọ metụtara ịmịnye ọbara dị ntakịrị, mana nwere ike ịgụnye:

• Ọbara ọgbụgba
• Da mba ma ọ bụ inwe isi ọkụ
• Otutu punctures chọta veins
• Hematoma (ọbara ọbara n'okpuru akpụkpọ)
• Ofufe Ọrịa (ntakịrị ihe egwu oge ọ bụla anụ ahụ agbajiri)

Elghetany MT, Schexneider KI, Banki K. Erythrocytic nsogbu. Na: McPherson RA, Pincus MR, eds. Henry’s Clinical Diagnosis and Management site na Labozọ Laboratory. 23 nke ed. St Louis, MO: Elsevier; 2017: isi 32.

Gallagher PG. Hemolytic anemias: mkpụrụ ndụ ọbara ọbara na ntụpọ metabolic. Na: Goldman L, Schafer AI, eds. Ọgwụ Goldman-Cecil. Nke 26th. Philadelphia, PA: Elsevier; 2020: isi 152.

Papachristodoulou D. Ike metabolism. Na: Naish J, Syndercombe Court D, eds. Ahụike Ahụike. Nke atọ ed. Philadelphia, PA: Elsevier; 2019: isi 3.

van Solinge WW, van Wijk R. Enzymes nke mkpụrụ ndụ ọbara uhie. Na: Rifai N, ed. Akwụkwọ Tietz nke Clinical Chemistry na Molecular Diagnostics. Nke isii. Philadelphia, PA: Elsevier; 2018: isi 30.