Hormone ọgwụgwọ maka ọrịa kansa prostate

Usoro ọgwụgwọ Hormone maka ọrịa prostate na-eji ịwa ahụ ma ọ bụ ọgwụ iji belata ogo nke homonụ nwoke na nwanyị na ahụ nwoke. Nke a na - enyere aka belata uto nke kansa prostate.

Androgens bụ homonụ nwoke na nwanyị. Testosterone bụ otu ụdị isi nke androgen. Imirikiti testosterone na-eme site na testicles. Akụkụ adrenal na-ewepụtakwa obere ego.

Androgens na-eme ka mkpụrụ ndụ kansa cancer na-eto. Hormone ọgwụgwọ maka ọrịa prostate na-ebelata mmetụta nke androgen na ahụ. Ọ nwere ike ime nke a site na:

• Ikwusi ihe ogwu site na ime androgens site na iji ogwu ma obu ogwu
• Na-egbochi omume nke androgens n'ime ahụ
• Ikwusi aru ime androgens

Ọ fọrọ nke nta ka ọ bụrụ na a naghị eji ọgwụgwọ Hormone eme ihe maka ndị nwere Stage I ma ọ bụ Stage II cancer cancer.

A na-ejikarị ya eme ihe maka:

• Ọrịa cancer dị elu nke gbasaa gabiga gland
• Ọrịa cancer nke na-azaghị ịwa ahụ ma ọ bụ radieshon
• Ọrịa cancer nke laghachiri ugboro ugboro

Enwere ike iji ya:

• Tupu radieshon ma ọ bụ ịwa ahụ iji nyere aka belata shuga
• Yana ọgwụgwọ radieshon maka kansa nke nwere ike ịlaghachi ọzọ

Usoro ọgwụgwọ kachasị dị na ya bụ ị drugsụ ọgwụ na-ebelata ọnụọgụ androgens nke testicles mere. A na-akpọ ha analogs na-ahapụ luteinizing hormone (LH-RH) analogs (injections) na anti-androgens (mbadamba ụrọ). Ndị ọgwụ ndị a na-eme ka etrogen dị elu karịa ịwa ahụ. A na-akpọ ụdị ọgwụgwọ a mgbe ụfọdụ "nkedo kemịkal."

Mụ nwoke ndị na-anata ọgwụgwọ androgen na-ebelata ọgwụgwọ kwesịrị iso dọkịta na-akọwa ọgwụ ndị a:

• N’ime ọnwa atọ rue ọnwa isii mgbe ịmalitechara ọgwụgwọ
• Ọ dịkarịa ala otu ugboro n'afọ, iji nyochaa ọbara mgbali ma mee ule shuga (glucose) na ule cholesterol
• Inweta ule ọbara PSA iji nyochaa otu usoro ọgwụgwọ si arụ ọrụ

A na-enye analogs LH-RH dị ka ogbugba ma ọ bụ dịka obere ihe etinye n'okpuru akpụkpọ ahụ. A na-enye ha ebe ọ bụla site na otu ugboro n'ọnwa ruo otu ugboro n'afọ. Ọgwụ ndị a gụnyere:

• Leuprolide (Lupron, Eligard)
• Goserelin (Zoladex)
• Nkọwapụta (Trelstar)
• Histrelin (Vantas)

Ọgwụ ọzọ, degarelix (Firmagon), bụ onye mgbagha LH-RH. Ọ na-ebelata etrogen ogo ngwa ngwa ma nwee mmetụta dị ole na ole. A na-eji ya na ụmụ nwoke nwere ọrịa kansa.

Fọdụ ndị dọkịta na-atụ aro ịkwụsị na ịmaliteghachi ọgwụgwọ (ọgwụgwọ oge). Approachzọ a gosipụtara na-enyere aka belata mmetụta mmetụta ọgwụgwọ hormone. Otú ọ dị, ọ bụghị ihe doro anya ma ọ bụrụ na usoro ọgwụgwọ na-agbanwe agbanwe na-arụ ọrụ yana ọgwụgwọ na-aga n'ihu. Studiesfọdụ ọmụmụ na-egosi na ọgwụgwọ na-aga n'ihu dị irè karị ma ọ bụ na a ga-eji ọgwụgwọ na-emechi emechi nanị maka ụdị ọrịa cancer prostate.

Gerywa ahụ iji wepu testicles (castration) na-akwụsị mmepụta nke ọtụtụ androgens na ahụ. Nke a na-ebelata ma ọ bụ na-egbochi ọrịa cancer na-eto eto. Ọ bụ ezie na ọ dị irè, ọtụtụ ụmụ nwoke anaghị ahọrọ nhọrọ a.

Drugsfọdụ ọgwụ na-arụ ọrụ site na igbochi mmetụta nke androgen na mkpụrụ ndụ kansa cancer. A na-akpọ ha mgbochi-androgens. A na-ewere ọgwụ ndị a dị ka ọgwụ. A na-ejikarị ha eme ihe mgbe ọgwụ ndị na-eme ka etrogen dị ala anaghịzi arụ ọrụ.

Anti-androgens gụnyere:

• Flutamide (Eulexin)
• Enzalutamide (Xtandi)
• Abiraterone (Zytiga)
• Bicalutamide (Casodex)
• Nilutamide (Nilandron)

Enwere ike ịmepụta Androgens n'akụkụ ndị ọzọ nke ahụ, dịka gland adrenal. Fọdụ mkpụrụ ndụ cancer prostate nwekwara ike ịme androgens. Ọgwụ atọ na - enyere aka ịkwụsị ahụ ịme akpụrogens site na anụ ahụ na - abụghị nke amụ.

Ọgwụ abụọ, ketoconazole (Nizoral) na aminoglutethimide (Cytradren), na-agwọ ọrịa ndị ọzọ mana a na-ejikarị ya agwọ ọrịa kansa prostate. Onye nke atọ, abiraterone (Zytiga) na-agwọ ọrịa prostate toro ogologo nke gbasaruru ebe ndị ọzọ na ahụ.

N'ime oge, ọrịa cancer prostate na-eguzogide ọgwụ ọgwụgwọ hormone. Nke a pụtara na ọrịa kansa chọrọ naanị ogo nke androgen ka o too. Mgbe nke a mere, enwere ike ịgbakwunye ọgwụ ndị ọzọ ma ọ bụ ọgwụgwọ ndị ọzọ.

Androgens nwere mmetụta n'ahụ niile. Ya mere, ọgwụgwọ ndị na-eme ka homonụ ndị a belata nwere ike ịkpata ọtụtụ mmetụta dị iche iche. Ogologo oge ị na-a medicinesụ ọgwụ ndị a, o yikarịrị ka ị ga-enwe mmetụta ndị ọzọ.

Ha gụnyere:

• Nsogbu inweta ụlọ ma ghara inwe mmasị na mmekọahụ
• Mbelata amụ na amụ
• Ihe mgbu na-ekpo ọkụ
• Ike ma ọ bụ gbajiri ọkpụkpụ
• Obere, ike gwụrụ
• Mgbanwe nke abụba ọbara, dị ka cholesterol
• Mgbanwe na ọbara shuga
• Ibu ibu
• Ọnọdụ mgbanwe
• Ike ọgwụgwụ
• Uto nke ara ara, obi nro

Usoro ọgwụgwọ orrogen nwere ike ịbawanye ihe egwu maka ọrịa shuga na ọrịa obi.

Ikpebi maka ọgwụgwọ hormonal maka ọrịa prostate nwere ike ịbụ mkpebi siri ike na ọbụlagodi. Ofdị ọgwụgwọ nwere ike ịdabere na:

• Ihe egwu gị maka kansa ịlọghachi
• Kedu ka ọrịa kansa gị si dị elu
• Ma ọgwụgwọ ndị ọzọ akwụsịla ịrụ ọrụ
• Ma ọrịa kansa agbasala

Inggwa onye na-eweta gị gbasara nhọrọ gị na uru na ọghọm dị na ọgwụgwọ ọ bụla nwere ike inyere gị aka ịme mkpebi kacha mma maka gị.

Usoro ọgwụgwọ androgen ADT; Usoro ọgwụgwọ androgen suppression; Jikọtara androgen mgbochi; Orchiectomy - ọrịa cancer; Castration - ọrịa cancer

• Nwoke omumu anatomi

Ebe nrụọrụ weebụ American Cancer Society. Hormone ọgwụgwọ maka ọrịa kansa prostate. www.cancer.org/cancer/prostate-cancer/treating/hormone-therapy.html. Emelitere December 18, 2019. Nabata March 24, 2020.

Weebụsaịtị National Cancer Institute. Hormone ọgwụgwọ maka ọrịa kansa prostate. www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet. Emelitere February 28, 2019. Nabata December 17, 2019.

Weebụsaịtị National Cancer Institute. Ọgwụ cancer cancer (PDQ) - ụdị ọkachamara ahụike. www.cancer.gov/types/prostate/hp/prostate-treatment-pdq. Emelitere Jenụwarị 29, 2020. Nweta March 24, 2020.

National Comprehensive Cancer Network weebụsaịtị. NCCN usoro nlekọta ahụike na oncology (ntuziaka NCCN): ọrịa cancer prostate. 1.dị 1.2020. www.nccn.org/professionals/physician_gls/pdf/prostate.pdf. Emelitere March 16, 2020. Nabata March 24, 2020.

Eggener S. Hormonal ọgwụgwọ maka ọrịa kansa prostate. Na: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, ndị ọzọ. Ulology nke Campbell-Walsh. Agba nke iri na abụọ. Philadelphia, PA: Elsevier; 2021: Isi 161.

• Ọrịa Cancer