Oral vs. Injectable MS Treatment: Kedu ihe dị iche?

Ndinaya

• Chohọrọ ọgwụ MS
• Ọgwụ na-enye onwe ya ọgwụ
• Avonex (interferon beta-1a)
• Betaseron (interferon beta-1b)
• Copaxone (acetate glatiramer)
• Ọpụpụ (interferon beta-1b)
• Glatopa (acetate glatiramer)
• Plegridy (pegylated interferon beta-1a)
• Rebif (interferon beta-1a)
• Ọgwụ ogwu igba ogwu
• Lemtrada (alemtuzumab)
• Mitoxantrone hydrochloride
• Ocrevus (ocrelizumab)
• Tysabri (natalizumab)
• Oral onu
• Aubagio (teriflunomide)
• Gilenya (fingolimod)
• Tecfidera (dimethyl fumarate)
• Wepu

Nchịkọta

Multiple sclerosis (MS) bụ nsogbu autoimmune nke usoro ahụ ji alụso ọrịa ọgụ na-awakpo mkpuchi myelin nke irighiri akwara gị. N’ikpeazụ, nke a na-ebute irighiri akwara ndị ahụ n’onwe ha.

Enweghị ọgwụgwọ maka MS, mana ọgwụgwọ nwere ike inye aka jikwaa mgbaàmà ahụ ma belata nrịanrịa nke ọrịa ahụ.

Emere usoro ọgwụgwọ na-agbanwe ọrịa (DMTs) iji mee ka ọrịa ahụ kwụsị ogologo oge, belata nlọghachi azụ, ma gbochie mmebi ọhụụ ka ọ ghara ime.

Enwere ike iji onu ogwu DMT ma obu ogwu ogwu. Injections nwere ike ịbụ ịgbanye onwe gị n'ụlọ ma ọ bụ nye ya dị ka nsị ogwu n'ime ebe a na-agwọ ọrịa.

Ma ọgwụ ọgwụ ọnụ na ọgwụ injectation nwere uru na mmetụta dị egwu. Ọtụtụ na-abịa ịdọ aka na ntị doro anya site na Nchịkwa nri na ọgwụ ọjọọ (FDA).

Chohọrọ ọgwụ MS

Enwere ọtụtụ ihe ị ga-atụle mgbe ị na-ekpebi n'etiti usoro ọgwụgwọ na nke inject. Dị ka ihe atụ, a na-a oralụ ọgwụ a na-a oralụ n’ọnụ kwa ụbọchị, ebe a na-a mostụkarị ọtụtụ ọgwụ ndị a na-agbanye ọgwụ n’ahụ́.

Dọkịta gị nwere ike inyere gị aka ịtụle ihe egwu dị na uru ma kpebie nhọrọ kacha mma maka gị.

Mmasị gị dị mkpa na nhọrọ nke usoro ọgwụgwọ. Ihe ndị dị mkpa ịchọrọ iji tụlee bụ:

• irè ọgwụ
• mmetụta ya
• ugboro ole nke onunu ogwu
• usoro eji enye ọgwụ

Ọgwụ na-enye onwe ya ọgwụ

Ọgwụ ndị na-agbanye onwe ha na-emepụta ụdị DMTs kachasị ukwuu. A na-eji ha maka ọgwụgwọ ogologo oge nke nlọghachi azụ na-enyefe MS (RRMS).

Onye ọkachamara ahụike ga-azụ gị na usoro ntanye ahụ ka ị nwee ike ịnye ọgwụ gị. Ọtụtụ n'ime ọgwụ ndị a nwere ike ibute ịcha ọbara ọbara, ọzịza, na mgbu na saịtị ogwu ahụ, na mgbakwunye na mmetụta ndị ọzọ.

Avonex (interferon beta-1a)

• Uru: na-arụ ọrụ dị ka dịghịzi usoro modulator, nwere antiviral Njirimara
• Dose ugboro na usoro: kwa izu, intramuscular ogwu ogbugba
• Mmetụta ndị na-agakarị nwere ike ịgụnye: isi ọwụwa, ọrịa na-efe efe
• Dọ aka na ntị gụnyere: imeju enzymes na ọbara zuru ezu (CBC) nwere ike ọ dị mkpa ka enyocha gị

Betaseron (interferon beta-1b)

• Uru: na-arụ ọrụ dị ka dịghịzi usoro modulator, nwere antiviral Njirimara
• Dose ugboro na usoro: ụbọchị ọ bụla, ịgba ntụtụ subcutaneous
• Mmetụta ndị na-agakarị nwere ike ịgụnye: flu-dị ka ihe mgbaàmà, obere ọbara ọcha cell (WBC) gụọ
• Dọ aka na ntị gụnyere: imeju enzymes na CBC nwere ike ọ dị mkpa ka a nyochaa ha

Copaxone (acetate glatiramer)

• Uru: na-arụ ọrụ dị ka usoro modulator, mgbochi na myelin
• Dose ugboro na usoro: kwa ụbọchị ma ọ bụ ugboro atọ kwa izu, ọgwụ subcutaneous
• Mmetụta ndị na-agakarị nwere ike ịgụnye: flushing, mkpụmkpụ nke ume, ọkụ ọkụ, obi mgbu
• Dọ aka na ntị gụnyere: ogwu ogbugba saịtị nwere ike na-adịgide adịgide indented n'ihi na ọdụdụ anụ ahụ na-ebibi (dị ka a N'ihi, nlezianya adiana nke ogwu ogbugba saịtị na-atụ aro)

Ọpụpụ (interferon beta-1b)

• Uru: na-arụ ọrụ dị ka dịghịzi usoro modulator, nwere antiviral Njirimara
• Dose ugboro na usoro: ụbọchị ọ bụla, ịgba ntụtụ subcutaneous
• Mmetụta ndị na-agakarị nwere ike ịgụnye: flu-dị ka mgbaàmà, isi ọwụwa
• Dọ aka na ntị gụnyere: imeju enzymes na CBC nwere ike ọ dị mkpa ka a nyochaa ha

Glatopa (acetate glatiramer)

• Uru: na-arụ ọrụ dị ka usoro modulator, mgbochi na myelin
• Dose ugboro na usoro: kwa ụbọchị, ogwu n'okpuru
• Mmetụta ndị na-agakarị nwere ike ịgụnye: acha ọbara ọbara, ọzịza, ihe mgbu na saịtị ịgba ogwu
• Dọ aka na ntị gụnyere: ogwu ogbugba saịtị nwere ike na-adịgide adịgide indented n'ihi na ọdụdụ anụ ahụ na-ebibi (dị ka a N'ihi, nlezianya adiana nke ogwu ogbugba saịtị na-atụ aro)

Plegridy (pegylated interferon beta-1a)

• Uru: na-arụ ọrụ dị ka dịghịzi usoro modulator, nwere antiviral Njirimara
• Dose ugboro na usoro: ọ bụla izu abụọ, subcutaneous ogwu ogbugba
• Mmetụta ndị na-agakarị nwere ike ịgụnye: flu-dị ka ihe mgbaàmà
• Dọ aka na ntị gụnyere: imeju enzymes nwere ike ọ dị mkpa ka a nyochaa

Rebif (interferon beta-1a)

• Uru: na-arụ ọrụ dị ka dịghịzi usoro modulator, nwere antiviral Njirimara
• Dose ugboro na usoro: ugboro atọ kwa izu, subcutaneous ogwu ogbugba
• Mmetụta ndị na-agakarị nwere ike ịgụnye: flu-dị ka ihe mgbaàmà
• Dọ aka na ntị gụnyere: imeju enzymes nwere ike ọ dị mkpa ka a nyochaa

Ọgwụ ogwu igba ogwu

Typedị nhọrọ injectable ọzọ maka ịgwọ MS bụ ọgwụ infravenous. Kama ịbanye na sistemụ gị intramuscularly ma ọ bụ subcutaneously, infusions na-abanye kpọmkwem n'ime akwara.

A gha inye ndi ogwu ahu ihe ndi ahu n’enye ogwu. A naghị edozi doses ahụ mgbe mgbe.

Mgbapu ogwu nwere ike ibute onodu ojoo nke oria na mgbakwunye nsogbu ndi ozo.

Ocrelizumab (Ocrevus) bụ naanị ọgwụ nke FDA kwadoro maka ndị nwere isi na-aga n'ihu MS (PPMS). A kwadoro ya iji na-emeso RRMS.

Lemtrada (alemtuzumab)

• Uru: na-egbochi mkpụrụ ndụ mgbochi myelin
• Dose ugboro: kwa ụbọchị ruo ụbọchị ise; mgbe otu afọ gachara, kwa ụbọchị ruo ụbọchị atọ
• Mmetụta ndị na-agakarị nwere ike ịgụnye: ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, isi ọwụwa, ọkụ ọkụ, ọkọ
• Dọ aka na ntị gụnyere: nwere ike ibute kansa na idiopathic thrombocytopenic purpura (IPT), ọgbụgba ọgbụgba

Mitoxantrone hydrochloride

Ọgwụ a bụ naanị dị ka ọgwụ ọnyà.

• Uru: na-arụ ọrụ dị ka dịghịzi usoro modulator na suppressor
• Dose ugboro: otu ugboro kwa ọnwa atọ (njedebe nke ndụ 8 ruo 12 karịrị afọ abụọ ruo atọ)
• Mmetụta ndị na-agakarị nwere ike ịgụnye: ntutu isi, ọgbụgbọ, amenorrhea
• Dọ aka na ntị gụnyere: nwere ike imebi obi na leukemia; ọ bụ naanị ihe kwesịrị ekwesị maka ndị nwere nsogbu RRMS siri ike, n'ihi nnukwu ihe egwu dị egwu

Ocrevus (ocrelizumab)

• Uru: lekwasịrị mkpụrụ ndụ B anya, nke bụ WBC nke na-emebi akwara
• Dose ugboro: izu abụọ iche iche maka ọgwụ abụọ mbụ; kwa ọnwa isii ọ bụla maka doses ọzọ
• Mmetụta ndị na-agakarị nwere ike ịgụnye: flu-dị ka mgbaàmà, ọrịa
• Dọ aka na ntị gụnyere: nwere ike ibute ọrịa kansa yana, n'oge ụfọdụ, mmeghachi omume infusion na-eyi ndụ egwu

Tysabri (natalizumab)

• Uru: na-egbochi irighiri ihe adhesion, nke na-emebi usoro mgbochi
• Dose ugboro: kwa izu anọ
• Mmetụta ndị na-agakarị nwere ike ịgụnye: isi ọwụwa, nkwonkwo mgbu, ike ọgwụgwụ, ịda mba, mgbaka afọ
• Dọ aka na ntị gụnyere: nwere ike ibute ihe ize ndụ nke na-aga n'ihu multifocal leukoencephalopathy (PML), nwere ike ịnwụ ọrịa ụbụrụ

Oral onu

Ọ bụrụ na ahụghị gị mma na agịga, enwere nhọrọ ọnụọgụ maka ịgwọ MS. Na-eme kwa ụbọchị ma ọ bụ ugboro abụọ kwa ụbọchị, ọgwụ ndị a na-eji ọnụ ekwu bụ ndị kachasị mfe iji aka ha nye onwe ha mana ịchọrọ ka ị na-enwe usoro nhazi oge niile.

Aubagio (teriflunomide)

• Uru: na-arụ ọrụ dị ka usoro modulator, na-egbochi mmebi akwara
• Dose ugboro: kwa ụbọchị
• Mmetụta ndị na-agakarị nwere ike ịgụnye: isi ọwụwa, mgbanwe imeju (dịka imeju gbasaa ma ọ bụ enzymes dị elu), ọgbụgbọ, ntutu isi, belata ọnụ ọgụgụ WBC
• Dọ aka na ntị gụnyere: nwere ike ibute mmerụ ahụ na oke ọmụmụ

Gilenya (fingolimod)

• Uru: na-egbochi mkpụrụ ndụ T ịhapụ ịhapụ lymph
• Dose ugboro: kwa ụbọchị
• Mmetụta ndị na-agakarị nwere ike ịgụnye: flu-dị ka mgbaàmà, elu imeju enzymes
• Dọ aka na ntị gụnyere: nwere ike ibute mgbanwe n’ọbara mgbali elu, arụ ọrụ imeju, na ịrụ ọrụ obi

Tecfidera (dimethyl fumarate)

• Uru: nwere mgbochi mkpali Njirimara, na-echebe irighiri akwara na myelin site na mmebi
• Dose ugboro: ugboro abụọ kwa ụbọchị
• Mmetụta ndị na-agakarị nwere ike ịgụnye: mgbanwe eriri afọ, belatara ọnụ ọgụgụ WBC, enzymes imeju dị elu
• Dọ aka na ntị gụnyere: nwere ike ibute mmeghachi omume nfụkasị siri ike, gụnyere anaphylaxis

Wepu

Ebumnuche nke ọgwụgwọ MS bụ ijikwa mgbaàmà, ịchịkwa nlọghachi azụ, ma belata ọganihu ogologo oge nke ọrịa ahụ.

Usoro ọgwụgwọ MS injectable na-abịa n'ụdị abụọ: injectable onwe na infusions intravenous. Ekwesighi ka otutu ogwu ogwu dika otutu ogwu ogwu, nke anara kwa ubochi.

Usoro ọgwụgwọ MS niile nwere uru, nsonaazụ, na ihe egwu. Ihe kachasị mkpa bụ na ị na-ewere ọgwụgwọ gị dịka edepụtara, n'agbanyeghị ụdị ọgwụgwọ ị na-eme.

Ọ bụrụ na mmetụta ndị ọzọ ga-eme ka ịchọrọ ịhapụ ọgwụgwọ, gwa dọkịta gị. Ha nwere ike inyere gị aka ịhọrọ nhọrọ kacha mma maka gị.