Odee: William Ramirez
OfbọChị Okike: 16 Septemba 2021
DatebọChị Mmelite: 1 Novemba 2024
Anonim
Cannabidiol (CBD) and Health | Pharmacology
Vidio: Cannabidiol (CBD) and Health | Pharmacology

Ndinaya

Cannabidiol bụ kemịkalụ na Cannabis sativa osisi, makwaara dị ka wii wii ma ọ bụ hemp. Achọpụtala ihe karịrị kemịkal iri asatọ, nke a maara dị ka cannabinoids na Cannabis sativa plant. Ọ bụ ezie na delta-9-tetrahydrocannabinol (THC) bụ isi ihe na-arụsi ọrụ ike na wii wii, a na-enwetakwa cannabidiol site na hemp, nke nwere nanị obere THC.

Igha uzo nke Ugbo Ugbo 2018 mere ka iwu kwadoro ire hemp na ngwaahịa hemp na U.S. Ma nke ahụ apụtaghị na ngwaahịa niile cannabidiol sitere na hemp bụ iwu. Ebe ọ bụ na a mụọla cannabidiol dị ka ọgwụ ọhụrụ, enweghị ike itinye ya na iwu ma ọ bụ nri nri. Ọzọkwa, cannabidiol enweghị ike ịgụnye na ngwaahịa ahịa na nkwupụta ọgwụgwọ. Cannabidiol nwere ike tinye ya na ngwaahịa "ịchọ mma" yana naanị ma ọ bụrụ na o nwere ihe na-erughị 0.3% THC. Ma, a ka nwere ngwaahịa ndị akpọrọ dị ka ihe mgbakwunye nri n'ahịa nwere cannabidiol. Ọnụ ọgụgụ nke cannabidiol dị na ngwaahịa ndị a anaghị ekwukarị nke ọma na akara ngwaahịa ahụ.

A na-ejikarị Cannabidiol eme ihe maka ọgba aghara (epilepsy). A na-ejikwa ya maka nchekasị, mgbu, ọrịa akwara a na-akpọ dystonia, ọrịa Parkinson, ọrịa Crohn, na ọtụtụ ọnọdụ ndị ọzọ, mana enweghị ezigbo ihe mmụta sayensị iji kwado ojiji ndị a.

Natural Medicines Comprehensive database ọnụego na-arụ ọrụ dabere na ihe akaebe sayensị dịka usoro a si dị: Mmetụta, Ikekwe Ọ Ga-arụpụta Ihe, Ikekwe Ọ Ga-arụpụta Ihe, Ikekwe Ọ Dị Irè, Ikekwe Ọ Dị Irè, Adịghị Eme Ihe, na Ego ezughi ezu iji gosi.

Radị irè maka AKWIKWỌ (CBD) ndị dị ka ndị a:


Ikekwe ọ dị irè maka ...

  • Ọrịa ọdịdọ (akwụkwụ). E gosipụtara otu ngwaahịa cannabidiol (Epidiolex, GW Pharmaceuticals) iji belata njide na ndị okenye na ụmụaka nwere ọnọdụ dịgasị iche iche metụtara njikọta. Ngwaahịa a bụ ọgwụ ọgwụ edere maka ịgwọ njide nke Dravet syndrome, ọrịa Lennox-Gastaut, ma ọ bụ mgbagwoju tubular sclerosis. E gosipụtakwala iji belata njigide na ndị nwere ọrịa Sturge-Weber, ọrịa ọrịa na-efe efe metụtara ọrịa febrile (FIRES), na ọrịa mkpụrụ ndụ ihe nketa kpọmkwem nke na-akpata encephalopathy. Mana anabataghị ya maka ịgwọ ụdị ọgụ ndị a. A na-ewere ngwaahịa a yana ọgwụ mgbochi ọgụ. Cannabfọdụ ngwaahịa cannabidiol nke emere na ụlọ nyocha na-amụkwa maka akwụkwụ. Ma nyocha dị oke, ọ nweghịkwa ngwaahịa ndị a kwadoro dị ka ọgwụ ọgwụ.

Ezughi oke akaebe iji gosipụta irè maka ...

  • Typedị ọrịa obi na-efe efe (ọrịa Crohn). Nnyocha mbụ emere na-egosi na ị cannabụ cannabidiol adịghị ebelata ọrụ ọrịa na ndị okenye nwere ọrịa Crohn.
  • Ọrịa shuga. Nnyocha emere na mbụ gosiri na ị cannabụ cannabidiol anaghị eme ka shuga shuga na-achịkwa ndị okenye nwere ụdị ọrịa shuga abụọ.
  • Nsogbu mmegharị nke akara mkpịsị akwara na-enweghị isi (dystonia). O doro anya ma ọ bụrụ na cannabidiol bara uru maka dystonia.
  • Ọnọdụ eketa eketa site na nkwarụ mmụta (ọrịa na-emebi emebi- X). Nnyocha mbụ mere na-egosi na itinye gelidio cannabidiol nwere ike belata nchekasị ma melite omume na ụmụaka nwere ọrịa X na-emebi emebi.
  • Ọnọdụ nke transplant na-awakpo ahụ (ọrịa aka-versus-host ma ọ bụ GVHD). Ọrịa graft-vesos bụ nsogbu nke nwere ike ịdapụta mgbe ọkpụkpụ ọkpụkpụ gachara. Nnyocha emere na mbụ achọpụtala na ị cannabụ cannabidiol kwa ụbọchị na-amalite ụbọchị 7 tupu ụmị ọkpụkpụ na-aga n'ihu ruo ụbọchị 30 mgbe transplant gasịrị nwere ike ịgbatị oge ọ ga-ewe mmadụ iji zụlite GVHD.
  • Ọrịa ụbụrụ anyị ketara eketa nke na-emetụta mmegharị, mmetụta uche, na iche echiche (ọrịa Huntington). Nnyocha mbụ mere na-egosi na ị cannabụ cannabidiol kwa ụbọchị adịghị eme ka ihe mgbaàmà nke ọrịa Huntington ka mma.
  • Ọrịa multiple sclerosis (MS). Nnyocha mbụ na-egosi na iji ọgwụ cannabidiol gbaa n'okpuru ire nwere ike imeziwanye ihe mgbu na akwara muscle na ndị nwere MS.
  • Nwepu na heroin, morphine, na ọgwụ ndị ọzọ opioid. Nnyocha mbụ mere na-egosi na ị cannabụ cannabidiol maka ụbọchị 3 nwere ike belata agụụ na nchekasị nke ndị nwere nsogbu ị heroụ ọgwụ heroin.
  • Ọrịa Parkinson. Nnyocha e mere na mbụ gosiri na cannabidiol nwere ike belata nchekasị na mgbaàmà mgbaàmà uche na ndị nwere ọrịa Parkinson.
  • Ọrịa. Nnyocha mbụ mere na-egosi na ị cannabụ cannabidiol na-eme ka mgbaàmà na ahụike dị mma na ndị nwere isi ihe.
  • Kwụsị ise siga. Nnyocha mbụ emere na-egosi na ịmịnye cannabidiol na inhaler maka otu izu nwere ike belata ọnụ ọgụgụ sịga nke ndị na-ese anwụrụ ọkụ na-anwa ịkwụsị.
  • Anxietydị nchekasị nke ụjọ na-atụ n'ụfọdụ ọnọdụ mmekọrịta mmadụ na ibe ya (ọgba aghara nchekasị). Nchoputa mbu gosiputara na cannabidiol nwere ike ime ka ndi mmadu nwee nsogbu a. Mana o doro anya ma ọ bụrụ na ọ na-enyere aka belata nchekasị n'oge ikwu okwu n'ihu ọha.
  • Otu ìgwè ọnọdụ na-egbu mgbu nke na-emetụta nkwonkwo agba na akwara (nsogbu oge ma ọ bụ TMD). Nnyocha mbụ emere na-egosi na itinye mmanụ nwere cannabidiol na akpụkpọ ahụ nwere ike belata ihe mgbu ndị nwere TMD.
  • Nerve mmebi na aka na ụkwụ (peripheral neuropathy).
  • Ọrịa ụbụrụ.
  • Ehighị ụra nke ọma.
  • Ọnọdụ ndị ọzọ.
Achọrọ ihe akaebe ọzọ iji gosipụta irè nke cannabidiol maka ojiji ndị a.

Cannabidiol nwere mmetụta na ụbụrụ. Ihe kpatara nsogbu ndị a edoghị anya. Otú ọ dị, cannabidiol yiri ka ọ na-egbochi nkwụsị nke chemical na ụbụrụ nke na-emetụta ihe mgbu, ọnọdụ, na ọrụ uche. Na-egbochi nkwụsịtụ nke mmiri ọgwụ a ma na-arịwanye elu n'ọbara ya yiri ka ọ na-ebelata mgbaàmà psychotic metụtara ọnọdụ ndị dị ka ịme ihe. Cannabidiol nwekwara ike igbochi ụfọdụ mmetụta psychoactive nke delta-9-tetrahydrocannabinol (THC). Ọzọkwa, cannabidiol yiri ka ọ na-ebelata ihe mgbu na nchekasị.

Mgbe e were ya n'ọnụ: Cannabidiol bụ Enwere ike nchekwa mgbe ejiri ọnụ ya ma ọ bụ fesa ya n'okpuru ire ya. Cannabidiol dị na 300 mg kwa ụbọchị ejiriwo ọnụ na-echekwa ya ruo ọnwa isii. A na-eji ọnụ dị elu nke 1200-1500 mg kwa ụbọchị n'ọnụ n'enweghị nsogbu ruo izu 4. A na-anabata ọgwụ cannabidiol ọgwụ (Epidiolex) ka a na-eji ọnụ were ọgwụ 25 mg / kg kwa ụbọchị. Cannabidiol sprays nke etinyere n’okpuru ire ejirila na doses nke 2.5 mg ruo izu 2.

Reportedfọdụ akọ mmetụta nke cannabidiol gụnyere akọrọ ọnụ, ọbara mgbali elu, isi ọwụwa, na iro ụra. E gosipụtakwala ihe ịrịba ama nke mmerụ imeju na ụfọdụ ndị ọrịa, mana nke a adịkarịghị.

Mgbe etinyere ya na akpụkpọ: Enweghị ozi zuru ezu a pụrụ ịdabere na ya iji mara ma ọ bụrụ na cannabidiol dị mma ma ọ bụ ihe mmetụta dị na ya nwere ike ịbụ.

Akpachapụ anya na ịdọ aka na ntị:

Ime ime na ara-ara: Cannabidiol bụ EBEGH UN UNSAFE iji ma ọ bụrụ na ị dị ime ma ọ bụ na-enye nwa ara. Cannabidiol ngwaahịa nwere ike merụọ ya na ndị ọzọ Efrata nwere ike na-emerụ ka nwa ebu n'afọ ma ọ bụ nwa ọhụrụ. Nọrọ na mma n'akụkụ ma zere ojiji.

Mụaka: Ngwaahịa ọgwụ cannabidiol ọgwụ (Epidiolex) bụ Enwere ike nchekwa mgbe a na-eji ọnụ were dozie ya ruo 25 mg / kg kwa ụbọchị. Ngwaahịa a kwadoro maka ojiji maka ụfọdụ ụmụaka 1 afọ na okenye.

Ọrịa imeju: Ndị nwere ọrịa imeju nwere ike iji obere ọgwụ nke cannabidiol jiri ya tụnyere ndị ọrịa ahụike.

Ọrịa Parkinson: Somefọdụ nnyocha e mere na mbụ na-egosi na ị takingụ ọgwụ ike cannabidiol dị elu nwere ike ime ka mmegharị ahụ na ịma jijiji na-akawanye njọ na ụfọdụ ndị nwere ọrịa Parkinson.

Agafeghị oke
Kpachara anya na nchikota a.
Brivaracetam (Briviact)
Ahụ Brivaracetam gbanwere ma mebie. Cannabidiol nwere ike ibelata otu ngwa ngwa ahụ na-akụda brivaracetam. Nke a nwere ike ịbawanye ogo nke brivaracetam na ahụ.
Carbamazepine (Tegretol)
Carbamazepine gbanwere ma mebie ya. Cannabidiol nwere ike belata ngwa ngwa ahụ na-emebi carbamazepine. Nke a nwere ike ime ka carbamazepine dị elu na ahụ wee nwekwuo mmetụta ya.
Clobazam (Onfi)
Clobazam gbanwere na imeju site na imeju. Cannabidiol nwere ike belata ngwa ngwa imeju na-agbari clobazam. Nke a nwere ike ime ka mmetụta nke clobazam dịkwuo elu.
Eslicarbazepine (Aptiom)
Eslicarbazepine gbanwere ma mebie ya. Cannabidiol nwere ike belata ngwa ngwa ahụ na-agbada eslicarbazepine. Nke a nwere ike ime ka eslicarbazepine dị elu na ahụ site na obere obere.
Everolimus (Zostress)
Everolimus gbanwere ma mebie ya site na ahụ ya. Cannabidiol nwere ike belata ngwa ngwa ahụ na-agbada everolimus. Nke a nwere ike ịbawanye ogo nke everolimus n'ime ahụ.
Lithium
Highernweta ọgwụ dị elu nke cannabidiol nwere ike ịbawanye ọkwa nke lithium. Nke a nwere ike ịbawanye ohere nke nsị lithium.
Ọgwụ gbanwere umeji (Cytochrome P450 1A1 (CYP1A1) substrates)
Thefọdụ ọgwụ na-agbanwe ma mebie site na imeju. Cannabidiol nwere ike ibelata ngwa ngwa imeju na-agbari ụfọdụ ọgwụ. Na tiori, iji cannabidiol tinyere ọgwụ ụfọdụ nke imeju mebiri nwere ike ịbawanye mmetụta na mmetụta nke ụfọdụ ọgwụ. Tupu i jiri cannabidiol, gwa onye na-eweta ahụike gị ma ọ bụrụ nara ọgwụ ọ bụla nke imeju gbanwere.

Medicationsfọdụ ọgwụ ndị imeju gbanwere gụnyere chlorzoxazone (Lorzone) na theophylline (Theo-Dur, ndị ọzọ).
Ọgwụ gbanwere umeji (Cytochrome P450 1A2 (CYP1A2) substrates)
Thefọdụ ọgwụ na-agbanwe ma mebie site na imeju. Cannabidiol nwere ike ibelata ngwa ngwa imeju na-agbari ụfọdụ ọgwụ. Na tiori, iji cannabidiol tinyere ọgwụ ụfọdụ nke imeju mebiri nwere ike ịbawanye mmetụta na mmetụta nke ụfọdụ ọgwụ. Tupu i jiri cannabidiol, gwa onye na-eweta ahụike gị ma ọ bụrụ nara ọgwụ ọ bụla nke imeju gbanwere.

Medicationsfọdụ ọgwụ ndị imeju gbanwere gụnyere amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, ndị ọzọ), verapamil (Calan, Isoptin, ndị ọzọ), na ndị ọzọ.
Ọgwụ gbanwere umeji (Cytochrome P450 1B1 (CYP1B1) substrates)
Thefọdụ ọgwụ na-agbanwe ma mebie site na imeju. Cannabidiol nwere ike ibelata ngwa ngwa imeju na-agbari ụfọdụ ọgwụ. Na tiori, iji cannabidiol tinyere ọgwụ ụfọdụ nke imeju mebiri nwere ike ịbawanye mmetụta na mmetụta nke ụfọdụ ọgwụ. Tupu i jiri cannabidiol, gwa onye na-eweta ahụike gị ma ọ bụrụ nara ọgwụ ọ bụla nke imeju gbanwere.

Somefọdụ ọgwụ ndị imeju gbanwere gụnyere theophylline (Theo-Dur, ndị ọzọ), omeprazole (Prilosec, Omesec), clozapine (Clozaril, FazaClo), progesterone (Prometrium, ndị ọzọ), lansoprazole (Prevacid), flutamide (Eulexin), oxaliplatin (Eloxatin) ), erlotinib (Tarceva), na caffeine.
Ọgwụ gbanwere umeji (Cytochrome P450 2A6 (CYP2A6) substrates)
Thefọdụ ọgwụ na-agbanwe ma mebie site na imeju. Cannabidiol nwere ike ibelata ngwa ngwa imeju na-agbari ụfọdụ ọgwụ. Na tiori, iji cannabidiol tinyere ọgwụ ụfọdụ nke imeju mebiri nwere ike ịbawanye mmetụta na mmetụta nke ụfọdụ ọgwụ. Tupu i jiri cannabidiol, gwa onye na-eweta ahụike gị ma ọ bụrụ nara ọgwụ ọ bụla nke imeju gbanwere.

Fọdụ ọgwụ ndị imeju gbanwere gụnyere nicotine, chlormethiazole (Heminevrin), coumarin, methoxyflurane (Penthrox), halothane (Fluothane), valproic acid (Depacon), disulfiram (Antabuse), na ndị ọzọ.
Ọgwụ gbanwere umeji (Cytochrome P450 2B6 (CYP2B6) substrates)
Thefọdụ ọgwụ na-agbanwe ma mebie site na imeju. Cannabidiol nwere ike ibelata ngwa ngwa imeju na-agbari ụfọdụ ọgwụ. Na tiori, iji cannabidiol tinyere ọgwụ ụfọdụ nke imeju mebiri nwere ike ịbawanye mmetụta na mmetụta nke ụfọdụ ọgwụ. Tupu i jiri cannabidiol, gwa onye na-eweta ahụike gị ma ọ bụrụ nara ọgwụ ọ bụla nke imeju gbanwere.

Fọdụ ọgwụ ndị imeju gbanwere gụnyere ketamine (Ketalar), phenobarbital, orphenadrine (Norflex), secobarbital (Seconal), na dexamethasone (Decadron).
Ọgwụ gbanwere umeji (Cytochrome P450 2C19 (CYP2C19) substrates)
Thefọdụ ọgwụ na-agbanwe ma mebie site na imeju. Cannabidiol nwere ike ibelata ngwa ngwa imeju na-agbari ụfọdụ ọgwụ. Na tiori, iji cannabidiol tinyere ọgwụ ụfọdụ nke imeju mebiri nwere ike ịbawanye mmetụta na mmetụta nke ụfọdụ ọgwụ. Tupu i jiri cannabidiol, gwa onye na-eweta ahụike gị ma ọ bụrụ nara ọgwụ ọ bụla nke imeju gbanwere.

Fọdụ ọgwụ ndị imeju gbanwere gụnyere proton pump inhibitors gụnyere omeprazole (Prilosec), lansoprazole (Prevacid), na pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); na ndị ọzọ.
Ọgwụ gbanwere umeji (Cytochrome P450 2C8 (CYP2C8) substrates)
Thefọdụ ọgwụ na-agbanwe ma mebie site na imeju. Cannabidiol nwere ike ibelata ngwa ngwa imeju na-agbari ụfọdụ ọgwụ. Na tiori, iji cannabidiol tinyere ọgwụ ụfọdụ nke imeju mebiri nwere ike ịbawanye mmetụta na mmetụta nke ụfọdụ ọgwụ. Tupu i jiri cannabidiol, gwa onye na-eweta ahụike gị ma ọ bụrụ nara ọgwụ ọ bụla nke imeju gbanwere.
Medicationsfọdụ ọgwụ ndị imeju gbanwere gụnyere amiodarone (Cordarone), carbamazepine (Tegretol), chloroquine (Aralen), diclofenac (Voltaren), paclitaxel (Taxol), repaglinide (Prandin) na ndị ọzọ.
Ọgwụ gbanwere umeji (Cytochrome P450 2C9 (CYP2C9) substrates)
Thefọdụ ọgwụ na-agbanwe ma mebie site na imeju. Cannabidiol nwere ike ibelata ngwa ngwa imeju na-agbari ụfọdụ ọgwụ. Na tiori, iji cannabidiol tinyere ọgwụ ụfọdụ nke imeju mebiri nwere ike ịbawanye mmetụta na mmetụta nke ụfọdụ ọgwụ. Tupu i jiri cannabidiol, gwa onye na-eweta ahụike gị ma ọ bụrụ nara ọgwụ ọ bụla nke imeju gbanwere.

Medicationsfọdụ ọgwụ ndị imeju gbanwere gụnyere ọgwụ ndị na-adịghị egbochi ọgwụ ọjọọ (NSAIDs) dị ka diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), piroxicam (Feldene), na celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); na ndị ọzọ.
Ọgwụ gbanwere umeji (Cytochrome P450 2D6 (CYP2D6) substrates)
Thefọdụ ọgwụ na-agbanwe ma mebie site na imeju. Cannabidiol nwere ike ibelata ngwa ngwa imeju na-agbari ụfọdụ ọgwụ. Na tiori, iji cannabidiol tinyere ọgwụ ụfọdụ nke imeju gbariri nwere ike ịbawanye mmetụta na mmetụta nke ụfọdụ ọgwụ. Tupu i jiri cannabidiol, gwa onye na-eweta ahụike gị ma ọ bụrụ nara ọgwụ ọ bụla nke imeju gbanwere.

Fọdụ ọgwụ ndị imeju gbanwere gụnyere amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Proxetil) ), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), na ndị ọzọ.
Ọgwụ gbanwere umeji (Cytochrome P450 3A4 (CYP3A4) substrates)
Thefọdụ ọgwụ na-agbanwe ma mebie site na imeju. Cannabidiol nwere ike ibelata ngwa ngwa imeju na-agbari ụfọdụ ọgwụ. Na tiori, iji cannabidiol tinyere ọgwụ ụfọdụ imeju mebiri nwere ike ịbawanye mmetụta na nsonaazụ nke ụfọdụ ọgwụ. Tupu i jiri cannabidiol, gwa onye na-eweta ahụike gị ma ọ bụrụ nara ọgwụ ọ bụla nke imeju gbanwere.

Fọdụ ọgwụ ndị imeju gbanwere gụnyere alprazolam (Xanax), amlodipine (Norvasc), clarithromycin (Biaxin), cyclosporine (Sandimmune), erythromycin, lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), trixof) (Halcion), verapamil (Calan, Isoptin) na ọtụtụ ndị ọzọ.
Ọgwụ gbanwere umeji (Cytochrome P450 3A5 (CYP3A5) substrates)
Thefọdụ ọgwụ na-agbanwe ma mebie site na imeju. Cannabidiol nwere ike ibelata ngwa ngwa imeju na-agbari ụfọdụ ọgwụ. Na tiori, iji cannabidiol tinyere ọgwụ ụfọdụ nke imeju gbariri nwere ike ịbawanye mmetụta na mmetụta nke ụfọdụ ọgwụ. Tupu i jiri cannabidiol, gwa onye na-eweta ahụike gị ma ọ bụrụ nara ọgwụ ọ bụla nke imeju gbanwere.

Medicationsfọdụ ọgwụ ndị imeju gbanwere gụnyere testosterone, progesterone (Endometrin, Prometrium), nifedipine (Adalat CC, Procardia XL), cyclosporine (Sandimmune), na ndị ọzọ.
Ọgwụ gbanwere umeji (ọgwụ ọgwụ Glucuronidated)
Thefọdụ ọgwụ na-agbanwe ma mebie site na imeju. Cannabidiol nwere ike ibelata ngwa ngwa imeju na-agbari ụfọdụ ọgwụ. Iwere cannabidiol tinyere ọgwụ ụfọdụ imeju na-agbaji nwere ike ịbawanye mmetụta na nsonaazụ nke ọgwụ ndị a.
Fọdụ n'ime ọgwụ ndị a imeju gbanwere gụnyere acetaminophen (Tylenol, ndị ọzọ) na oxazepam (Serax), haloperidol (Haldol), lamotrigine (Lamictal), morphine (MS Contin, Roxanol), zidovudine (AZT, Retrovir), na ndị ọzọ.
Ọgwụ ndị na-ebelata mmebi nke ọgwụ ndị ọzọ site na imeju (Cytochrome P450 2C19 (CYP2C19) inhibitors)
A na-agbaji Cannabidiol site na imeju. Fọdụ ọgwụ nwere ike ibelata ngwa ngwa imeju imebi cannabidiol. Iwere cannabidiol tinyere ọgwụ ndị a nwere ike ịbawanye nsonaazụ na nsonaazụ nke cannabidiol.
Medicationsfọdụ ọgwụ nwere ike ibelata mmebi cannabidiol n'ime imeju gụnyere cimetidine (Tagamet), fluvoxamine (Luvox), omeprazole (Prilosec); ticlopidine (Ticlid), topiramate (Topamax), na ndị ọzọ.
Ọgwụ ndị na-ebelata mmebi nke ọgwụ ndị ọzọ na imeju (Cytochrome P450 3A4 (CYP3A4) inhibitors)
A na-agbaji Cannabidiol site na imeju. Fọdụ ọgwụ nwere ike ibelata ngwa ngwa imeju imebi cannabidiol. Iwere cannabidiol tinyere ọgwụ ndị a nwere ike ịbawanye nsonaazụ na nsonaazụ nke cannabidiol.
Fọdụ ọgwụ nwere ike ibelata etu imeju si gbarie ngwa ngwa cannabidiol gụnyere amiodarone (Cordarone), clarithromycin (Biaxin), diltiazem (Cardizem), erythromycin (E-mycin, Erythrocin), indinavir (Crixivan), ritonavir (Norvir), saquinavir (Fortovase) , Invirase), na ọtụtụ ndị ọzọ.
Ọgwụ ndị na-eme ka mmebi nke ọgwụ ndị ọzọ dị na umeji (Cytochrome P450 3A4 (CYP3A4) inducers)
A na-agbaji Cannabidiol site na imeju. Fọdụ ọgwụ nwere ike ịbawanye ngwa ngwa imeju imeju cannabidiol. Iwere cannabidiol tinyere ọgwụ ndị a nwere ike ibelata mmetụta nke cannabidiol.
Fọdụ n’ime ọgwụ ndị a gụnyere carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), na ndị ọzọ.
Ọgwụ ndị na-eme ka mmebi nke ọgwụ ndị ọzọ site na imeju (Cytochrome P450 2C19 (CYP2C19) inducers)
A na-agbaji Cannabidiol site na imeju. Fọdụ ọgwụ nwere ike ịbawanye ngwa ngwa imeju imeju cannabidiol. Iwere cannabidiol tinyere ọgwụ ndị a nwere ike ibelata mmetụta nke cannabidiol.
Fọdụ ọgwụ ndị nwere ike ịbawanye mmebi nke cannabidiol n'ime imeju gụnyere carbamazepine (Tegretol), prednisone (Deltasone), na rifampin (Rifadin, Rimactane).
Methadone (Dolophine)
Imeju na-agbaji methadone. Cannabidiol nwere ike belata ngwa ngwa imeju na-agbada methadone. Iwere cannabidiol yana methadone nwere ike ime ka mmetụta na mmetụta nke methadone dịkwuo elu.
Okwudiri (Banzel)
Rufinamide gbanwere ma mebie ya site na ahụ. Cannabidiol nwere ike belata otu ngwa ngwa ahụ si emebi rufinamide. Nke a nwere ike ime ka rufinamide dị na ahụ dịkwuo obere site na obere obere.
Ọgwụ ịgwọ ọrịa (CNS depressants)
Cannabidiol nwere ike ime ka ụra na ụra. A na-akpọ ọgwụ ndị na-akpata ihi ụra ụra. Iwere cannabidiol yana ọgwụ na-eme ka mmadụ daa ụra nwere ike ime ka ụra buru oke ụra.

Medicationsfọdụ ọgwụ na-akụda mmụọ gụnyere benzodiazepines, pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), thiopental (Pentothal), fentanyl (Duragesic, Sublimaze), morphine, propofol (Diprivan), na ndị ọzọ.
Sirolimus (Rapamune)
Sirolimus gbanwere ma mebie ya site na ahụ. Cannabidiol nwere ike belata ngwa ngwa ahụ na-agbada sirolimus. Nke a nwere ike ịbawanye ogo nke sirolimus n'ime ahụ.
Stiripentol (Diacomit)
Stiripentol gbanwere ma mebie ya. Cannabidiol nwere ike belata ngwa ngwa ahụ na-akụda stiripentol. Nke a nwere ike ime ka stiripentol dị elu na ahụ wee nwekwuo mmetụta ya.
Tacrolimus (Mmemme)
Tacrolimus gbanwere ma mebie ya. Cannabidiol nwere ike belata otu ngwa ngwa ahụ na-etida tacrolimus. Nke a nwere ike ime ka tacrolimus dịkwuo elu n'ime ahụ.
Topiramate ntụ ntụ (Tompamax)
Topiramate mmiri na-agbanwe ma mebie ya. Cannabidiol nwere ike belata ngwa ngwa ahụ na-akụda topiramate. Nke a nwere ike ịbawanye ogo nke Topiramate na ahụ site na obere obere.
Nyochaa
Valproic acid nwere ike ibute mmerụ imeju. Iwere cannabidiol na valproic acid nwere ike ime ka ọnya imeju nwee ike. Cannabidiol na / ma ọ bụ valproic acid nwere ike ịkwụsị, ma ọ bụ belata ọgwụ ahụ nwere ike belata.
Warfarin
Cannabidiol nwere ike ịbawanye ọkwa nke warfarin, nke nwere ike ịbawanye ohere maka ịgba ọbara. Cannabidiol na / ma ọ bụ warfarin nwere ike ịkwụsị, ma ọ bụ belata ọgwụ ahụ nwere ike belata.
Zonisamide
Zonisamide gbanwere ma mebie ahụ. Cannabidiol nwere ike belata ngwa ngwa ahụ na-akụda zonisamide. Nke a nwere ike ịbawanye ogo nke zonisamide n'ime ahụ site na obere obere.
Herbs na Mmeju na ogwuura Njirimara
Cannabidiol nwere ike ime ka ụra ma ọ bụ ụra. Iji ya na ahihia ndi ozo na ihe ndi ozo nke nwere otu ihe puru ime ka ura buru oke ura. Fọdụ n'ime mkpá akwụkwọ na ọgwụ ndị a gụnyere calamus, California poppy, catnip, hops, Jamaican dogwood, kava, L-tryptophan, melatonin, sage, SAMe, St. John's wort, sassafras, skullcap, na ndị ọzọ.
Mmanya na-egbu egbu (Ethanol)
Iwere cannabidiol na mmanya na-abawanye ole cannabidiol nke ahụ na-etinye. Nke a nwere ike ịbawanye mmetụta na nsonaazụ nke cannabidiol.
Abụba na nri nwere abụba
Iwere cannabidiol na nri nke nwere abụba ma ọ bụ ma ọ dịkarịa ala nwere ụfọdụ abụba, na-eme ka ọnụ ọgụgụ nke cannabidiol na-etinye n'ahụ. Nke a nwere ike ịbawanye mmetụta na nsonaazụ nke cannabidiol.
Mmiri ara
Iwere cannabidiol na mmiri ara ehi na-eme ka cannabidiol mụbaa nke ahụ. Nke a nwere ike ịbawanye mmetụta na nsonaazụ nke cannabidiol.
A na-amụ usoro ndị a na nyocha sayensị:

NDUL okenye

Site n'ọnụ:
  • Maka akwụkwụ: Ejirila ọgwụ cannabidiol ọgwụ (Epidiolex). Ntinye mmalite nke akwadoro maka ọrịa Lennox-Gastaut na ọrịa Dravet bụ 2.5 mg / kg ugboro abụọ kwa ụbọchị (5 mg / kg / day). Mgbe otu izu gasịrị, a pụrụ ịgbatị dose ahụ ruo 5 mg / kg ugboro abụọ kwa ụbọchị (10 mg / kg / day). Ọ bụrụ na onye ahụ azaghị ọgwụ a, ihe kachasị atụ bụ 10 mg / kg ugboro abụọ kwa ụbọchị (20 mg / kg / day). Startingkpụrụ mmalite a tụrụ aro maka mgbagwoju anya nke ọrịa sclerosis bụ 2.5 mg / kg ugboro abụọ kwa ụbọchị (5 mg / kg / day). Enwere ike ịbawanye nke a kwa izu kwa izu ma ọ bụrụ na ọ dị mkpa, ruo na nke kachasị 12.5 mg / kg ugboro abụọ kwa ụbọchị (25 mg / kg / day). Enweghị ihe akaebe sayensị siri ike na ngwaahịa cannabidiol na-edeghị ederede bara uru maka akwụkwụ.
M .AKA

Site n'ọnụ:
  • Maka akwụkwụ: Ejirila ọgwụ cannabidiol ọgwụ (Epidiolex). Ntinye mmalite nke akwadoro maka ọrịa Lennox-Gastaut na ọrịa Dravet bụ 2.5 mg / kg ugboro abụọ kwa ụbọchị (5 mg / kg / day). Mgbe otu izu gasịrị, a pụrụ ịgbatị dose ahụ ruo 5 mg / kg ugboro abụọ kwa ụbọchị (10 mg / kg / day). Ọ bụrụ na onye ahụ azaghị ọgwụ a, ihe kachasị atụ bụ 10 mg / kg ugboro abụọ kwa ụbọchị (20 mg / kg / day). Startingkpụrụ mmalite a tụrụ aro maka mgbagwoju anya nke ọrịa sclerosis bụ 2.5 mg / kg ugboro abụọ kwa ụbọchị (5 mg / kg / day). Enwere ike ịbawanye nke a kwa izu kwa izu ma ọ bụrụ na ọ dị mkpa, rue ihe dịka 12.5 mg / kg ugboro abụọ kwa ụbọchị (25 mg / kg / day). Enweghị ihe akaebe sayensị siri ike na ngwaahịa cannabidiol na-edeghị ederede bara uru maka akwụkwụ.
2 - [(1R, 6R) -3-Methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl] -5-pentylbenzene-1,3-diol, CBD.

Iji mụtakwuo banyere otú e si dee isiokwu a, biko lee Natural Medicines Comprehensive database usoro.


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