Ovarian overproduction nke androgens

Ovarian overproduction nke androgens bụ ọnọdụ nke ovaries na-eme testosterone nke ukwuu. Nke a na - ebute mmepe nwoke na nwanyị. Androgens ndị sitere n'akụkụ ndị ọzọ nke ahụ nwekwara ike ime ka àgwà ụmụ nwoke tolite na ụmụ nwanyị.

N'ime ụmụ nwanyị ahụike, ovaries na adrenal glands na-emepụta ihe dịka 40% na 50% nke testosterone ahụ. Tumors nke ovaries na polycystic ovary syndrome (PCOS) nwere ike ha abụọ nwere ike ibute oke mmepụta androgen.

Ọrịa Cushing bụ nsogbu na pituitary gland nke na-eduga ọtụtụ corticosteroids. Corticosteroids na-eme ka ahụ ụmụ nwoke na-agbanwe n'ahụ ụmụ nwanyị. Tumors na adrenal glands nwekwara ike ịkpata ọtụtụ mmepụta nke androgens ma nwee ike ibute àgwà ụmụ nwoke na ụmụ nwanyị.

Nnukwu androgens dị n'ime nwanyị nwere ike ibute:

• Ihe otutu
• Mgbanwe na odidi nwanyi
• Mbelata nke ara
• Mee ka ntutu dịkwuo na nwoke, dịka na ihu, agba, na afọ
• Enweghị oge ịhụ nsọ (amenorrhea)
• Mmanụ anụahụ

Mgbanwe ndị a nwekwara ike ime:

• Mee ka ogo nke nwanyi ji abawanye
• Omimi nke olu
• Mee ka akwara buru ibu
• Iberibe ntutu na ntutu isi na ihu ihu na isi abụọ na isi

Onye na-ahụ maka ahụike gị ga-eme nyocha anụ ahụ. Ọbara ọ bụla na nyocha onyonyo enyere iwu ga-adabere na mgbaàmà gị, mana nwere ike ịgụnye:

• 17-hydroxyprogesterone ule
• ACTH ule (ọhụrụ)
• Nnyocha ọbara cholesterol
• Nyocha CT
• Nyocha DHEA
• Nnyocha nke glucose
• Nnwale insulin
• Pelvic ultrasound
• Nnwale prolactin (ọ bụrụ na oge abịaghị obere oge ma ọ bụ ọlị)
• Nnwale nke testosterone (testosterone n'efu na testosterone)
• TSH ule (ọ bụrụ na enwere ntutu)

Ọgwụgwọ dabere na nsogbu nke na-ebute ụba etrogen. Enwere ike ịnye ọgwụ iji belata ntutu ntutu na ụmụ nwanyị nwere oke ntutu, ma ọ bụ mezie usoro ịhụ nsọ. Mgbe ụfọdụ, enwere ike ịwa ahụ iji wepụ akpụ ovarian ma ọ bụ ụbụrụ adrenal.

Ọganihu ọgwụgwọ na-adabere n'ihe kpatara mmepụta etrogen gabigara ókè. Ọ bụrụ na nsogbu ahụ bụ site na akpụ ovarian, ịwa ahụ iji wepu akpụ nwere ike idozi nsogbu ahụ. Imirikiti etuto ovarian anaghị arịa kansa (enweghị isi) ọ gaghị alọghachi mgbe ewepụchara ha.

Na polycystic ovary syndrome, ndị na-esonụ jikoro nwere ike belata mgbaàmà mere site elu androgen etoju:

• Jiri nlezianya nyochaa
• Iwetulata ibu
• Mgbanwe nri
• Ọgwụ
• Imega ahụ mgbe niile

Enweghị ike na nsogbu n'oge ime ime nwere ike ime.

Womenmụ nwanyị ndị ọrịa polycystic ovary nwere ike nọrọ n'ihe ize ndụ ka ukwuu maka:

• Ọrịa shuga
• Ọbara mgbali elu
• Cholesterol dị elu
• Ibu
• Ọrịa Uterine

Womenmụ nwanyị ndị nwere ọrịa polycystic ovary nwere ike belata ngbanwe ha nke nsogbu ogologo oge site n'ịnọgide na-enwe oke ibu site na nri ahụike na mmega ahụ.

• Akwa ovaries arụ ọrụ
• Mmepe follicle

Bulun SE. Ahụike na usoro ọgwụgwọ nke usoro ọmụmụ ụmụ nwanyị. Na: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Akwụkwọ ọgụgụ Williams nke Endocrinology. Nke iri na anọ. Philadelphia, PA: Elsevier; 2020: isi 17.

Huddleston HG, Quinn M, Gibson M. Polycystic ovary syndrome na hirsutism. Na: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Akwụkwọ ọgụgụ nke Ọrịa edimụaka. 21nke. Philadelphia, PA: Elsevier; 2020: isi 567.

Lobo RA. Hyperandrogenism na oke androgen: physiology, etiology, nchoputa di iche, njikwa. Na: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Gynecology zuru ezu. Nke 7. Philadelphia, PA: Elsevier; 2017: isi 40.

Rosenfield RL, Barnes RB, Ehrmann DA. Hyperandrogenism, hirsutism, na ọrịa polycystic ovary. Na: Jameson JL, De Groot LJ, de Kretser DM, et al, ndị ọzọ. Endocrinology: Okenye na Ọrịa edimụaka. Nke 7. Philadelphia, PA: Elsevier Saunders; 2016: isi 133.