Distal gbasara akụrụ tubular acidosis

Distal gbasara akụrụ tubular acidosis bụ ọrịa na-apụta mgbe akụrụ anaghị ewepụsị acid n’ime ọbara ya n’ime mamịrị. N'ihi ya, oke acid na-anọgide n'ọbara (akpọrọ acidosis).

Mgbe ahụ rụrụ ọrụ ya nke ọma, ọ na - ewepụta acid. Ọ bụrụ na ewepụghị acid a ma ọ bụ wepụ ya, ọbara na-aghọ acidic oke. Nke a nwere ike iduga nha nrugharị nke electrolyte. O nwekwara ike ịkpata nsogbu na arụ ọrụ nke mkpụrụ ndụ ụfọdụ.

Akụrụ na-enyere aka ịchịkwa ogo acid ahụ site na iwepu acid n’ime ọbara ma wepụ ya na mamịrị.

Distal renal tubular acidosis (type I RTA) bụ ihe kpatara nkwarụ na akụrụ akụrụ nke na - akpata acid ka ọ wulite n'ime ọbara.

Idị M RTA kpatara ọnọdụ dịgasị iche iche, gụnyere:

• Amyloidosis, buildup nke protein na-adịghị ahụkebe, nke a na-akpọ amyloid, na anụ ahụ na akụkụ ahụ
• Ọrịa Fabry, bụ ihe na-adịghị mma n'ime ahụ nke ụdị abụba ụfọdụ
• Ọkwa dị elu nke calcium n'ọbara
• Ọrịa Sickle cell, mkpụrụ ndụ ọbara uhie nke na-adịkarị ka diski na-ewere sickle ma ọ bụ mpekere onwa
• Ọrịa Sjögren, ọrịa autoimmune nke glands na-ewepụta anya mmiri na mmiri na-ebibi
• Systemic lupus erythematosus, ọrịa autoimmune nke usoro ahụ ji alụso ọrịa ọgụ na-awakpo anụ ahụ dị mma
• Ọrịa Wilson, nsogbu ọrịa ketara eketa nke enwere oke ọla kọpa na anụ ahụ
• Iji ọgwụ ụfọdụ, dị ka amphotericin B, lithium, na analgesics

Mgbaàmà nke mgbasasị azụ nke tubular acidosis gụnyere nke ọ bụla n'ime ihe ndị a:

• Mgbagha ma ọ bụ ibelata nche
• Ike ọgwụgwụ
• Ọ bụzi nsogbu ụmụaka
• Mụbara iku ume
• Nkume akụrụ
• Nephrocalcinosis (oke calcium etinyere na akụrụ)
• Osteomalacia (nro nke ọkpụkpụ)
• Ike adịghị ike

Mgbaàmà ndị ọzọ nwere ike ịgụnye:

• Ọkpụkpụ mgbu
• Mbelata mmepụta mmamịrị
• Mụbara obi ọnụego ma ọ bụ oge ufodu obi otiti
• Ọkpụkpụ akwara
• Mgbu dị n’azụ, flank, ma ọ bụ afọ
• Ọkpụkpụ skeletal

Onye nlekọta ahụike ga-eme nyocha anụ ahụ ma jụọ maka ihe mgbaàmà gị.

Ule ndị a pụrụ inye iwu gụnyere:

• Ọbara ọbara ọbara
• Ọbara ọbara
• Mmamịrị pH
• Acid-ibu ule
• Bicarbonate infusion ule
• Urinalysis

A na-ahụ ebe a na-etinye calcium na akụrụ na nkume akụrụ na:

• X-ụzarị
• Ultrasound
• Nyocha CT

Ebumnuche bụ iweghachite ọkwa acid na usoro electrolyte na ahụ. Nke a ga - enyere aka idozi nsogbu ọkpụkpụ ma belata mkpụkọ calcium na akụrụ (nephrocalcinosis) na nkume akụrụ.

Ekwesịrị idozi ihe kpatara kpatara diski tubular acidosis, ma ọ bụrụ na enwere ike ịmata ya.

Ọgwụ ndị enwere ike ịde gụnyere gụnyere potassium citrate, sodium bicarbonate, na thiazide diuretics. Ndị a bụ ọgwụ alkaline nke na-enyere aka dozie ọnọdụ acidic nke ahụ. Sodium bicarbonate nwere ike idozi ọnwụ nke potassium na calcium.

A ghaghị ịgwọ ọrịa ahụ iji belata mmetụta na nsogbu ya, nke nwere ike ịdịgide ma ọ bụ na-eyi ndụ egwu. Ọtụtụ ikpe na-akawanye mma na ọgwụgwọ.

Kpọọ onye na-eweta gị ma ọ bụrụ na ị nwere mgbaàmà nke mgbapu akwara tubular acidosis.

Nweta enyemaka ahụike ozugbo ma ọ bụrụ na ị mepee ihe mgbaàmà mberede dịka:

• Mbelata nke uche
• Ọdịdọ
• Oké mbelata nke ịmụrụ anya ma ọ bụ nghazi

Enweghị mgbochi maka nsogbu a.

Gbasara tubular acidosis - distal; Enaldị Renal tubular acidosis type I; Pịnye M RTA; RTA - ịgha; Oge gboo RTA

• Akụrụ anatomi
• Akụrụ - ọbara na mmamịrị na-asọ

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Dixon BP. Renal tubular acidosis. Na: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Akwụkwọ ọgụgụ nke Ọrịa edimụaka. 21nke. Philadelphia, PA: Elsevier; 2020: isi 547.

Nke anọ JL. Ọrịa Acid-base. Na: Goldman L, Schafer AI, eds. Ọgwụ Goldman-Cecil. Nke 26th. Philadelphia, PA: Elsevier; 2020: isi 110.