Acromegaly

Acromegaly bu onodu nke oganihu hormone (GH) di n’aru.

Acromegaly bụ ọnọdụ na - adịghị ahụkebe. A na - ebute ya mgbe pituitary gland na - eme hormone buru ibu. Ọkpụkpụ pituitary bụ obere endocrine gland nke etinyere na ụbụrụ ụbụrụ. Ọ na-achịkwa, na-eme, ma wepụta ọtụtụ homonụ, gụnyere hormone nke na-eto eto.

Ọ na-abụkarị ọrịa na-adịghị ahụkarị (nke na-adịghị mma) nke pituitary gland na-ewepụta hormone nke na-eto eto. N'ọnọdụ ndị na-adịkarịghị, a pụrụ iketa etuto ahụ pituitary.

N'ime ụmụaka, ọtụtụ GH na-akpata gigantism karịa acromegaly.

Mgbaàmà nke acromegaly nwere ike ịgụnye nke ọ bụla n'ime ihe ndị a:

• Isi isi
• Ọbara na stool
• Ọrịa carpal
• Mbelata ike ahụ (adịghị ike)
• Mbelata ọhụụ
• Ike ọgwụgwụ
• Ogologo oke (mgbe nrụpụta GH karịrị malitere n'oge nwata)
• Oke ọsụsọ
• Isi ọwụwa
• Enba ụba nke obi, nke nwere ike ibute ịda mba
• Arsda ụda
• Mgbu mgbu
• Ihe mgbu, nkwonkwo nkwonkwo ejedebeghị, ọzịza nke ebe ọkpụkpụ na gburugburu nkwonkwo
• Nnukwu nku nke ihu, nnukwu agba na ire, ezé sara mbara
• Nnukwu ụkwụ (mgbanwe nha akpụkpọ ụkwụ), nnukwu aka (mgbanwe mgbanaka ma ọ bụ nchara aka)
• Nnukwu glands na akpụkpọ (sebaceous glands) na-eme ka mmanu mmanu mmanu, thickening nke anụ ahụ, akpụkpọ tags (growths)
• Ikwo ụra
• Mkpịsị aka ma ọ bụ mkpịsị aka ya agbatị, ya na ọzịza, ọbara ọbara, na mgbu

Mgbaàmà ndị ọzọ nwere ike ịpụta na ọrịa a:

• Colon polyps
• Ngafe ntutu na nwanyi (hirsutism)
• Ọbara mgbali elu
• Pịnye ụdị ọrịa shuga abụọ
• Mgbatị ume gị
• Ibu ibu

Onye nlekọta ahụike ga-eme nyocha anụ ahụ ma jụọ maka ihe mgbaàmà gị.

Enwere ike inye iwu nyocha ndị a iji kwado nyocha nke acromegaly ma lelee maka nsogbu:

• Ọbara ọbara
• Mkpụrụ hormone nke na-eto eto na nnwale mgbochi mkpokọta hormone
• Ihe na-akpata insulin nke yiri 1 (IGF-1)
• Prolactin
• Ọkpụkpụ x-ray
• MRI nke ụbụrụ, gụnyere pituitary gland
• Ihe omumu
• Nnyocha
• Ọmụmụ ụra

Enwere ike inye iwu nyocha ndị ọzọ iji chọpụta ma akụkụ ndị ọzọ nke pituitary na-arụ ọrụ nke ọma.

Gerywa ahụ iji wepu pituitary tumo nke na-akpata ọnọdụ a na-edozi GH na-adịghị mma. Mgbe ụfọdụ, etuto ahụ buru oke ibu iji wepu ya kpamkpam na acromegaly anaghị agwọ ya. N'okwu a, enwere ike iji ọgwụ na radieshon (rediotherapy) na-agwọ acromegaly.

Peoplefọdụ ndị nwere etuto ahụ nke siri ike nghọta iwepụ site na ịwa ahụ na-agwọ ya ọgwụ kama ịwa ahụ. Ọgwụ ndị a nwere ike igbochi mmepụta nke GH site na pituitary gland ma ọ bụ gbochie ọrụ nke GH n'akụkụ ndị ọzọ.

Mgbe ọgwụgwọ gasịrị, ị ga-ahụ onye na-eweta gị mgbe niile iji jide n'aka na pituitary gland na-arụ ọrụ nke ọma na acromegaly anaghị alaghachi. A na-atụ aro nyocha kwa afọ.

Ihe ndị a nwere ike ịnyekwu ozi na acromegaly:

• National Institute of Diabetes na Ọrịa na Ọrịa Akụrụ - www.niddk.nih.gov/health-information/endocrine-diseases/acromegaly
• Organizationtù Mba maka Nsogbu Na-adịghị - rarediseases.org/rare-diseases/acromegaly

Surgerywa ahụ nke pituitary na-aga nke ọma n'ọtụtụ mmadụ, dabere na oke etuto ahụ na ahụmịhe nke neurosurgeon nwere akpụ pituitary.

Enweghị ọgwụgwọ, ihe mgbaàmà ahụ ga-akawanye njọ. Ọnọdụ dị ka ọbara mgbali elu, ọrịa shuga, na ọrịa obi nwere ike ịpụta.

Kpọọ onye na-eweta gị ma ọ bụrụ:

• Have nwere mgbaàmà nke acromegaly
• Mgbaàmà gị anaghị emeziwanye na ọgwụgwọ

Enweghị ike igbochi Acromegaly. Ọgwụgwọ oge gboo nwere ike igbochi ọrịa ka ọ ghara ịka njọ ma nyere aka izere nsogbu.

Somatotroph adenoma; Uto hormone gabigara; Uto hormone na-ezobe pituitary adenoma; Pituitary ibu (na nwata)

• Ọgwụ endocrine

Katznelson L, Iwu ER Jr, Melmed S, et al. Acromegaly: usoro ndu ndi mmadu na-acho ndi mmadu. J Ọgwụ Endocrinol Metab. 2014; 99 (11): 3933-3951. PMID: 25356808 www.ncbi.nlm.nih.gov/pubmed/25356808.

Klein I. Endocrine ọrịa na ọrịa obi. Na: Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E, eds. Ọrịa Obi Braunwald: Akwụkwọ ọgụgụ nke Ọgwụ Ọrịa Cardiovascular. Nke iri. Philadelphia, PA: Elsevier Saunders; 2015: isi 81.

Melmed S. Acromegaly. Na: Jameson JL, De Groot LJ, de Kretser DM, et al, ndị ọzọ. Endocrinology: Okenye na Ọrịa edimụaka. Nke 7. Philadelphia, PA: Elsevier Saunders; 2016: isi 12.