Isi nke biliary cirrhosis

Nkeji bile bụ akpa na - esite na umeji na - abanye n’eriri afọ. Bile bụ ihe na-enyere aka na mgbaze. A na-akpọ eriri bile niile ọnụ biliary tract.

Mgbe ọnya bile ahụ zara ma ọ bụ gbanye ọkụ, nke a na-egbochi eruba nke bile. Mgbanwe ndị a nwere ike ibute ọgbụgba nke imeju a na-akpọ cirrhosis. A na-akpọ nke a biliary cirrhosis. Ọrịa cirrhosis dị elu nwere ike ibute ọdịda imeju.

Amaghị ihe kpatara ọnụọgụ bile na-egbuke egbuke na imeju. Otú ọ dị, isi biliary cirrhosis bụ nsogbu autoimmune. Nke ahụ pụtara na usoro ahụ gị ji alụso ọrịa ọgụ na-eji ọgụ eme ka anụ ahụ dị mma. Ọrịa ahụ nwere ike jikọta ya na nsogbu autoimmune dịka:

• Ọrịa Celiac
• Raynaud onu
• Ọrịa Sicca (anya akọrọ ma ọ bụ ọnụ)
• Ọrịa thyroid

Ọrịa a na-emetụtakarị ụmụ nwanyị ndị torola eto.

Ihe karịrị otu ọkara nke ndị mmadụ enweghị mgbaàmà n’oge nchoputa. Mgbaàmà na-ejikarị nwayọọ nwayọọ amalite. Mgbaàmà mbụ nwere ike ịgụnye:

• Nausea na afọ mgbu
• Ike ọgwụgwụ na ọnwụ nke ike
• Ebe abụba dị n'okpuru anụ ahụ
• Abụba oche
• Itching
• Enweghị agụụ na ọnwụ

Dị ka ọrụ imeju na-akawanye njọ, mgbaàmà nwere ike ịgụnye:

• Fluid buildup na ụkwụ (edema) na afọ (ascites)
• Agba odo na akpụkpọ ahụ, akpụkpọ anụ mucous, ma ọ bụ anya (jaundice)
• Na-acha ọbara ọbara na nkwụ aka
• N'ime nwoke, enweghi ike, ịbelata nke amụ, na ọzịza nke ara
• Mgbu na-agbaji na ọbara ọgbụgba na-adịghị ahụkebe, na-esikarị na veollen veins na tract digestive
• Mgbagwoju anya ma obu nsogbu iche echiche
• Icha akwa ma ọ bụ ụrọ nwere agba

Onye nlekọta ahụike ga-eme nyocha anụ ahụ.

Nyocha ndị a nwere ike ịlele iji hụ ma imeju gị ọ na-arụ ọrụ nke ọma:

• Nnwale ọbara Albumin
• Nlere ọrụ imeju (ọgwụ alkaline phosphatase dị ezigbo mkpa)
• Oge Prothrombin (PT)
• Cholesterol na ule lipoprotein ọbara

Nyocha ndị ọzọ nwere ike inyere aka chọpụta etu ọrịa imeju siri ike nwere ike ịgụnye:

• Ebuli elu immunoglobulin M n'ọbara
• Ọkpụkpụ imeju
• Anti-mitochondrial antibodies (nsonaazụ dị mma n'ihe gbasara 95% nke ikpe)
• Typesdị ultrasound pụrụ iche ma ọ bụ MRI nke na-atụle ọnya anụ ahụ (enwere ike ịkpọ elastography)
• Magnetik resonance cholangiopancreatography (MRCP)

Ebumnuche nke ọgwụgwọ bụ iji belata mgbaàmà ma gbochie nsogbu.

Cholestyramine (ma ọ bụ colestipol) nwere ike belata itching. Ursodeoxycholic acid nwere ike melite iwepu bile na obara. Nke a nwere ike ime ka ndụ mmadụ ka mma. Ogwu ohuru ana akpo obeticholic acid (Ocaliva) dikwa.

Ngwunye ọgwụ na-agbanwe vitamin na-eweghachite vitamin A, K, E na D, nke na-efu na oche abụba. Enwere ike ịgbakwunye calcium ma ọ bụ ọgwụ ndị ọzọ ọkpụkpụ iji gbochie ma ọ bụ gwọọ ọkpụkpụ adịghị ike ma ọ bụ nke dị nro.

Ogologo oge nlebara anya na ọgwụgwọ nke imeju imeju dị mkpa.

Ọkpụkpụ imeju nwere ike ịga nke ọma ma ọ bụrụ na emere ya tupu imeju imeju emee.

Nsonaazụ nwere ike ịdị iche. Ọ bụrụ na agwọghị ọnọdụ ahụ, ọtụtụ mmadụ ga-anwụ na-enweghị transplant imeju. Ihe dị ka otu ụzọ n’ụzọ anọ nke ndị rịara ọrịa a kemgbe afọ iri ga-enwe imeju imeju. Ndị dọkịta nwere ike iji ụdị ihe atụ mee ka amata oge kacha mma iji mee transplant. Ọrịa ndị ọzọ, dịka hypothyroidism na anaemia, nwekwara ike ịmalite.

Ọrịa cirrhosis na-aga n'ihu nwere ike ibute ọdịda imeju. Nsogbu nwere ike ịgụnye:

• Ọbara ọgbụgba
• Mmebi ụbụrụ (encephalopathy)
• Anya mmiri na electrolyte ahaghị nhata
• Akụrụ ọdịda
• Malabsorption
• Erighị nri na-edozi ahụ
• Ọkpụkpụ dị nro ma ọ bụ na-adịghị ike (osteomalacia ma ọ bụ osteoporosis)
• Ascites (mmịpụta mmiri n'ime oghere afọ)
• Nnukwu ihe ize ndụ nke kansa cancer

Kpọọ onye na-ahụ maka ọrụ gị ma ọ bụrụ na ịnwee:

• Ọzịza afọ
• Ọbara na stool
• Mgbagha
• Jaundice
• Itching nke anụ ahụ nke na-anaghị apụ apụ na enweghị njikọ na ihe ndị ọzọ
• Ọkpọ ọbara

Primary biliary cholangitis; PBC

• Cirrhosis - ihapu

• Usoro nri
• Okporo ụzọ

Eaton JE, Lindor KD. Primary biliary cholangitis. Na: Feldman M, Friedman LS, Brandt LJ, eds. Ọrịa Cancer Sleisenger na Ọrịa Cancer nke Fordtran. Nke 11. Philadelphia, PA: Elsevier; 2021: Isi nke 91.

Fogel EL, Sherman S. Ọrịa nke gallbladder na bile ducts. Na: Goldman L, Schafer AI, eds. Ọgwụ Goldman-Cecil. Nke 26th. Philadelphia, PA: Elsevier; 2020: isi 146.

Oriọna LW. Imeju: ọrịa ndị na-abụghị neoplastic. Na: Goldblum JR, Oriọna LW, McKenney JK, Myers JL, eds. Rosai na Ackerman si ịwa Ahụ Ọrịa. Nke 11. Philadelphia, PA: Elsevier; 2018: isi 19.

Smith A, Baumgartner K, Bositis C. Cirrhosis: nyocha na njikwa. Dibịa Am Am. 2019; 100 (12): 759-770. PMID: 31845776 pubmed.ncbi.nlm.nih.gov/31845776/.