HLA-B27 antigen

HLA-B27 bụ nyocha ọbara iji chọọ protein a hụrụ n’elu sel ọbara ọcha. A na-akpọ protein ahụ mmadụ leukocyte antigen B27 (HLA-B27).

Human leukocyte antigens (HLAs) bụ protein na-enyere usoro ahụ ji alụso ọrịa ọgụ aka ịmata ọdịiche dị n’etiti mkpụrụ ndụ nke ya na ihe ndị si mba ọzọ, ndị na-emerụ ahụ. Emere ha site na ntuziaka site na mkpụrụ ndụ ihe nketa eketa.

Achọrọ nlebara ọbara. Ọtụtụ mgbe, a na-ewepụta ọbara site na akwara nke dị n'ime ikpere aka ma ọ bụ azụ aka.

N'ọtụtụ oge, ọ nweghị usoro pụrụ iche iji kwadebe maka ule ahụ.

Mgbe etinyere agịga ahụ iji see ọbara, ị nwere ike ịnwe oke mgbu, ma ọ bụ naanị prick ma ọ bụ ihe na-agba agba. Mgbe nke ahụ gasịrị, enwere ike ịpị ụfọdụ mmiri.

Onye na-ahụ maka ahụike gị nwere ike ịtụ ule a iji nyere aka chọpụta ihe kpatara nkwonkwo mgbu, nkwesi ike, ma ọ bụ ọzịza. Enwere ike ime ule ahụ na ule ndị ọzọ, gụnyere:

• C-na-arụ ọrụ protein
• Erythrocyte sedimentation ọnụego (ESR)
• Rheumatoid ihe
• X-ụzarị

A na-ejikwa ule HLA kwekọọ na anụ ahụ enyere onyinye na anụ ahụ mmadụ nke na-enweta akụkụ akụkụ ahụ. Dịka ọmụmaatụ, enwere ike ịme ya mgbe mmadụ chọrọ transplant akụrụ ma ọ bụ ụmị ọkpụkpụ.

Nsonaazụ nkịtị (na-adịghị mma) pụtara HLA-B27 anọghị.

Nnwale dị mma pụtara HLA-B27 dị. Ọ na - egosi ihe egwu dịkarịrị ala ma ọ bụ nwee nsogbu ụfọdụ autoimmune. Ọrịa autoimmune bụ ọnọdụ na-adị mgbe usoro ahụ ji alụso ọrịa ọgụ wee mebie ma mebie anụ ahụ dị mma.

Nsonaazụ dị mma nwere ike inyere onye na-eweta gị aka ịchọpụta ụdị ọrịa ogbu na nkwonkwo a na-akpọ spondyloarthritis. Kinddị ogbu na nkwonkwo a gụnyere nsogbu ndị a:

• Ọkpụkpụ ankylosing
• Ogbu na nkwonkwo metụtara ọrịa Crohn ma ọ bụ ulcerative colitis
• Ọrịa ogbu na nkwonkwo (ogbu na nkwonkwo metụtara psoriasis)
• Ọrịa ogbu na nkwonkwo
• Sacroiliitis (mbufụt nke njikọ sacroiliac)
• Uveitis

Ọ bụrụ na ị nwere mgbaàmà ma ọ bụ ihe ịrịba ama nke spondyloarthritis, nyocha HLA-B27 dị mma nwere ike inyere aka kwado nyocha ahụ. Otú ọ dị, HLA-B27 dị na ụfọdụ ndị nkịtị ma ọ pụtaghị na ị nwere ọrịa.

Ihe ize ndụ sitere na ịmịnye ọbara dị ntakịrị, mana ọ nwere ike ịgụnye:

• Ọbara ọgbụgba
• Da mba ma ọ bụ inwe isi ọkụ
• Hematoma (ọbara na-agbakọta n'okpuru anụ ahụ)
• Ofufe Ọrịa (ntakịrị ihe egwu oge ọ bụla anụ ahụ agbajiri)

Lemụ mmadụ leukocyte antigen B27; Ankylosing spondylitis-HLA; Ọrịa ogbu na nkwonkwo Psoriatic-HLA; Ọrịa ogbu na nkwonkwo-HLA

• Nnwale ọbara

Chernecky CC, Berger BJ. Human Leukocyte Antigen (HLA) B-27 - ọbara. Na: Chernecky CC, Berger BJ, eds. Nnwale Laboratory na Usoro Nyocha. Nke isii. St Louis, MO: Elsevier Saunders; 2013: 654-655.

Fagoaga OR. Human leukocyte antigen: isi ihe mere mmadụ ji emekọrịta ihe banyere mmekọrịta mmadụ na ibe ya. Na: McPherson RA, Pincus MR, eds. Henry’s Clinical Diagnosis and Management site na Labozọ Laboratory. 23 nke ed. St Louis, MO: Elsevier; 2017: isi 49.

Inman RD. Na spondyloarthropathies. Na: Goldman L, Schafer AI, eds. Ọgwụ Goldman-Cecil. Nke iri abụọ na ise. Philadelphia, PA: Elsevier Saunders; 2016: isi 265.

McPherson RA, Massey HD. Isi nke usoro ahụ ji alụso ọrịa ọgụ na ọrịa immunologic. Na: McPherson RA, Pincus MR, eds. Henry’s Clinical Diagnosis and Management site na Labozọ Laboratory. 23 nke ed. St Louis, MO: Elsevier; 2017: isi 43.

Kpughee JD. Ọrịa Spondyloarthritis. Na: Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Ole na ole AJ, Weyand CM, eds. Clinical Immunology: cikpụrụ na Omume. Nke 5. Philadelphia, PA: Elsevier; 2019: isi 57.